Results 21 to 30 of about 7,673,385 (305)
The multi-functional eyes absent proteins [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2020 The Eyes Absent (EYA) proteins are the only known instance of a single polypeptide housing the following three separable biochemical activities: tyrosine phosphatase, threonine phosphatase, and transactivation. This uniquely positions the EYAs to participate in both transcriptional regulation and signal transduction pathways.
Rashmi S. Hegde +2 more
openaire +2 more sources
Clusterin, Other Extracellular Chaperones, and Eye Disease
Progress in retinal and eye research, 2021 Proteostasis refers to all the processes that maintain the correct expression level, location, folding and turnover of proteins, essential to organismal survival.
Mark R. Wilson +3 more
semanticscholar +1 more source
The Eyes Absent proteins in development and disease [PDF]
Cellular and Molecular Life Sciences, 2012 The Eyes Absent (EYA) proteins, first described in the context of fly eye development, are now implicated in processes as disparate as organ development, innate immunity, DNA damage repair, photoperiodism, angiogenesis, and cancer metastasis. These functions are associated with an unusual combination of biochemical activities: tyrosine phosphatase and ...
Emmanuel, Tadjuidje, Rashmi S, Hegde
openaire +2 more sources
Journal of Ophthalmic Inflammation and Infection, 2020 Purpose To determine whether unilateral acute anterior uveitis (AAU) induces ipsilateral changes in the tear fluid proteome. Methods Five patients (25–77 years old) with unilateral AAU were included. Tear fluid samples were obtained using Schirmer’s test
Jon Roger Eidet +7 more
doaj +1 more source
Vascular Adhesion Protein 1 in the Eye [PDF]
Journal of Ophthalmology, 2013 Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), a dual-function molecule with adhesive and enzymatic properties, is expressed on the surface of vascular endothelial cells of mammals. It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity and can be a prognostic ...
Wenting Luo +3 more
openaire +3 more sources
Interfacial residues in protein-protein complexes are in the eyes of the beholder
Proteins: Structure, Function, and Bioinformatics, 2023 Abstract Interactions between proteins are vital in almost all biological processes. The characterization of protein-protein interactions helps us understand the mechanistic basis of biological processes, thereby enabling the manipulation of proteins for biotechnological and clinical purposes. The interface residues of a protein-protein
Jayadevan Parvathy +3 more
openaire +4 more sources
Coronavirus disease 19 (COVID-19) and viral keratouveitis – unraveling the mystery
Indian Journal of Ophthalmology, 2023 To demonstrate viral proteins/inflammatory cytokines in a patient with unilateral keratouveitis. Retrospective case report. A 70-year-old Asian-Indian male presented with acute onset of blurring of vision in the left eye (OS) of 2 days duration.
Srinivasan Sanjay +8 more
doaj +1 more source
Function and aggregation in structural eye lens crystallins
Accounts of Chemical Research, 2020 Conspectus Crystallins are transparent, refractive proteins that contribute to the focusing power of the vertebrate eye lens. These proteins are extremely soluble, resisting aggregation for decades, even under crowded conditions. Crystallins have evolved
K. Roskamp +3 more
semanticscholar +1 more source
Investigation of Cas9 antibodies in the human eye
Nature Communications, 2022 Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum ...
Marcus A. Toral +8 more
doaj +1 more source