Results 31 to 40 of about 441,178 (207)
Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1 [PDF]
, 2002 The toxicity of an abnormally long polyglutamine [poly(Q)] tract within specific proteins is the molecular lesion shared by Huntington's disease (HD) and several other hereditary neurodegenerative disorders.
Benzer, Seymour, Kazemi-Esfarjani, Parsa
core +1 more source
Nature Communications, 2017 Aggregation of eye lens proteins leads to cataracts, a major cause of blindness. Here the authors use solid state NMR to probe the structure of γD-crystallin eye lens proteins aggregates, which are found to retain a native-like conformation.
Jennifer C. Boatz +4 more
doaj +1 more source
A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation
Neurobiology of Disease, 2006 In the Drosophila eye, proteins with an expanded polyglutamine (polyQ) tract form nuclear and cytoplasmic inclusions and produce cytotoxicity, demonstrated as loss of eye pigmentation and structural integrity.
Zahra Fayazi +5 more
doaj +1 more source
New insight into cataract formation -- enhanced stability through mutual attraction [PDF]
, 2007 Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures.
A. Stradner +12 more
core +2 more sources
Disease Models & Mechanisms, 2020 To gain a comprehensive view of the changes in host gene expression underlying Zika virus (ZIKV) pathogenesis, we performed whole-genome RNA sequencing (RNA-seq) of ZIKV-infected Drosophila adult flies.
Sneh Harsh +4 more
doaj +1 more source
BMC Veterinary Research, 2019 Background Organophosphate pesticides-OP-, like malathion, can alter the normal functioning of neuro-endocrine systems (e.g., hypothalamus-pituitary-thyroid-HPT- axis), and to interfere on the thyroidal homeostasis.
Juan B. Ortiz-Delgado +2 more
doaj +1 more source
Bone Morphogenetic Proteins and Their Receptors in the Eye
Experimental Biology and Medicine, 2007 The human genome encodes at least 42 different members of the transforming growth factor-β superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-β superfamily and are involved in numerous cellular functions including development, morphogenesis, cell proliferation ...
Robert J, Wordinger, Abbot F, Clark
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Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera [PDF]
International Journal of Biological Sciences, 2016 Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are endowed with several different functions besides being carriers for pheromones and odorants. Based on a previous report of a CSP acting as surfactant in the proboscis of the moth Helicoverpa armigera, we revealed the presence of orthologue proteins in two other moths Plutella ...
Zhu, Jiao +8 more
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Dry Eye: A Protein Conformational Disease
Investigative Ophthalmology & Visual Science, 2015 The purpose of this study was to determine whether aqueous-deficient dry eyes (ADDE) is a protein conformational disease. Up to now the therapeutic regimen has been based on empirical results, but these observations may unfold new theranostic approaches for ADDE management.Fifty ADDE patients and 46 healthy volunteers were recruited.
Mohammad, Azharuddin +4 more
openaire +2 more sources
Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. [PDF]
, 2017 Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the ...
Christian, Brian J +11 more
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