Results 31 to 40 of about 7,673,385 (305)

Association of Alpha-Crystallin with Fiber Cell Plasma Membrane of the Eye Lens Accompanied by Light Scattering and Cataract Formation

Membranes, 2021
α-crystallin is a major protein found in the mammalian eye lens that works as a molecular chaperone by preventing the aggregation of proteins and providing tolerance to stress in the eye lens.
Raju Timsina, Laxman Mainali
doaj   +1 more source

The Eyes Absent proteins in development and in developmental disorders [PDF]

Biochemical Society Transactions, 2021
The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation ...
Upendra Kumar Soni, Kaushik Roychoudhury, Rashmi S. Hegde   +2 more
openaire   +2 more sources

Immunological and antimicrobial molecules in human tears: a review and preliminary report*

African Vision and Eye Health, 2012
The human tear film is a multi-layered and chemically complex structure, which performs numerous functions relating to the health of the corneal surface.
R. Schnetler, W. D. H. Gillan, G. Koorsen   +2 more
doaj   +1 more source

Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level

Scientific Reports, 2017
The chemical nature of the non-tryptophan (non-Trp) fluorescence of porcine and human eye lens proteins was identified by Mass Spectrometry (MS) and Fluorescence Steady-State and Lifetime spectroscopy as post-translational modifications (PTM) of Trp and ...
A. Gakamsky, R. Duncan, N. M. Howarth, B. Dhillon, K. K. Buttenschön, D. Daly, D. Gakamsky   +6 more
semanticscholar   +1 more source

A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling

eLife, 2020
Phosphoinositides (PI) are key regulators of cellular organization in eukaryotes and genes that tune PI signaling are implicated in human disease mechanisms.
Deepti Trivedi, Vinitha CM, Karishma Bisht, Vishnu Janardan, Awadhesh Pandit, Bishal Basak, Shwetha H, Navyashree Ramesh, Padinjat Raghu   +8 more
doaj   +1 more source

VEGF regulates local inhibitory complement proteins in the eye and kidney

Journal of Clinical Investigation, 2016
Outer retinal and renal glomerular functions rely on specialized vasculature maintained by VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respectively. Dysregulation of RPE- and podocyte-derived
Lindsay S. Keir, Rachel Firth, Lyndsey Aponik, Daniel Feitelberg, S. Sakimoto, E. Aguilar, G. Welsh, A. Richards, Y. Usui, S. Satchell, V. Kuzmuk, R. Coward, Jonathan D Goult, Katherine R. Bull, Ruchi Sharma, K. Bharti, P. Westenskow, I. Michael, M. Saleem, M. Friedlander   +19 more
semanticscholar   +1 more source

Gold Nanorods as Colorful Chromogenic Substrates for Semiquantitative Detection of Nucleic Acids, Proteins, and Small Molecules with the Naked Eye.

Analytical Chemistry, 2016
Herein, we report for the first time a colorful chromogenic substrate, which displays vivid color responses in the presence of different concentration of analytes.
Xiaoming Ma, Zhitao Chen, P. Kannan, Zhenyu Lin, Bin Qiu, Longhua Guo   +5 more
semanticscholar   +1 more source

The acute phase response protein SERPINA3 is increased in tear fluid from the unaffected eyes of patients with unilateral acute anterior uveitis

Journal of Ophthalmic Inflammation and Infection, 2021
Background To identify candidate tear fluid biomarkers in patients with unilateral acute anterior uveitis (AAU) that can aid in the differentiation between these patients and patients with bacterial keratitis or healthy controls.
Jon Roger Eidet, Maja Akopian, Ole K. Olstad, Øystein Kalsnes Jørstad, Morten C. Moe, Goran Petrovski, Milaim Pepaj   +6 more
doaj   +1 more source

Global and Comparative Proteome Signatures in the Lens Capsule, Trabecular Meshwork, and Iris of Patients With Pseudoexfoliation Glaucoma

Frontiers in Molecular Biosciences, 2022
Pseudoexfoliation (PXF) is characterized by the accumulation of the exfoliative material in the eye and high rates of blindness if left untreated.
Prity Sahay, Prity Sahay, Munmun Chakraborty, Munmun Chakraborty, Aparna Rao, Aparna Rao   +5 more
doaj   +1 more source

RNA Binding Proteins in Eye Development and Disease: Implication of Conserved RNA Granule Components

Wiley Interdisciplinary Reviews - RNA, 2016
The molecular biology of metazoan eye development is an area of intense investigation. These efforts have led to the surprising recognition that although insect and vertebrate eyes have dramatically different structures, the orthologs or family members ...
Soma Dash, Archana D. Siddam, Carrie E. Barnum, S. Janga, S. Lachke   +4 more
semanticscholar   +1 more source