Results 11 to 20 of about 7,673,385 (305)
PLoS Neglected Tropical Diseases, 2010 Infection by Leptospira interrogans has been causally associated with human and equine uveitis. Studies in our laboratories have demonstrated that leptospiral lipoprotein LruA and LruB are expressed in the eyes of uveitic horses, and that antibodies ...
Ashutosh Verma +4 more
doaj +4 more sources
Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins
Antioxidants, 2021 The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and ...
Ana Álvarez-Barrios +5 more
doaj +2 more sources
The use of in-strip digestion for fast proteomic analysis on tear fluid from dry eye patients. [PDF]
PLoS ONE, 2018 Tear is an accessible fluid for exploring biomarkers of dry eye disease. This study describes a fast proteomic method by LC-Q-orbitrap-MS analysis with in-strip digestion and investigates the tear proteome of dry eye patients. Schirmer's strips were used
Zhu Huang, Chi-Xin Du, Xiao-Dong Pan
doaj +2 more sources
Heat Shock Proteins in the Human Eye [PDF]
International Journal of Proteomics, 2011 Heat shock proteins (Hsps) are believed to primarily protect and maintain cell viability under stressful conditions such as those occurring during thermal and oxidative challenges chiefly by refolding and stabilizing proteins.
L. Urbak, H. Vorum
semanticscholar +4 more sources
Effects of punctal occlusion on global tear proteins in patients with dry eye
Ocular Surface, 2017 PURPOSE To investigate effects of punctal occlusion on global tear protein levels in patients with dry eye. METHODS In this prospective, longitudinal, single-center study, nonabsorbable punctal plugs were inserted bilaterally into the lower punctum of ...
Lei Zhou, L Tong, David A Hollander
exaly +2 more sources
Glycation of nail proteins: from basic biochemical findings to a representative marker for diabetic glycation-associated target organ damage. [PDF]
PLoS ONE, 2015 Although assessment of glycated nail proteins may be a useful marker for monitoring of diabetes, their nature and formation are still poorly understood. Besides a detailed anatomical analysis of keratin glycation, the usefulness of glycated nail protein ...
Antoine Sadiki Kishabongo +7 more
doaj +1 more source
Keeping an eye on SOXC proteins [PDF]
Developmental Dynamics, 2014 The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate.
Lakshmi, Pillai-Kastoori +2 more
openaire +2 more sources
Profiling tear proteomes of patients with unilateral relapsed Behcet’s disease-associated uveitis using data-independent acquisition proteomics [PDF]
PeerJ, 2020 Purpose To explore whether unilateral relapse of Bechet’s disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers for uveitis recurrence and disease ...
Anyi Liang +5 more
doaj +2 more sources
Region-resolved multi-omics of the mouse eye
Cell Reports, 2023 Summary: The eye is a complex organ consisting of multiple compartments with unique and specialized properties, and small disturbances in one eye region can result in impaired vision and blindness. Although there have been advancements in ocular research,
Hang Xiang +7 more
doaj +1 more source
Metallothioneins, a Part of the Retinal Endogenous Protective System in Various Ocular Diseases
Antioxidants, 2023 Metallothioneins are the metal-rich proteins that play important roles in metal homeostasis and detoxification. Moreover, these proteins protect cells against oxidative stress, inhibit proapoptotic mechanisms and enhance cell differentiation and survival.
Daniel Jamrozik +5 more
doaj +1 more source