Results 11 to 20 of about 441,178 (207)

The Eyes Absent proteins in development and disease [PDF]

Cellular and Molecular Life Sciences, 2012
The Eyes Absent (EYA) proteins, first described in the context of fly eye development, are now implicated in processes as disparate as organ development, innate immunity, DNA damage repair, photoperiodism, angiogenesis, and cancer metastasis. These functions are associated with an unusual combination of biochemical activities: tyrosine phosphatase and ...
Emmanuel, Tadjuidje, Rashmi S, Hegde
openaire   +2 more sources

Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway

Journal of Ophthalmic Inflammation and Infection, 2020
Purpose To determine whether unilateral acute anterior uveitis (AAU) induces ipsilateral changes in the tear fluid proteome. Methods Five patients (25–77 years old) with unilateral AAU were included. Tear fluid samples were obtained using Schirmer’s test
Jon Roger Eidet, Øystein Kalsnes Jørstad, Ida G. Fostad, Ole K. Olstad, Ragnhild Ø. Sørland, Morten C. Moe, Goran Petrovski, Milaim Pepaj   +7 more
doaj   +1 more source

Vascular Adhesion Protein 1 in the Eye [PDF]

Journal of Ophthalmology, 2013
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), a dual-function molecule with adhesive and enzymatic properties, is expressed on the surface of vascular endothelial cells of mammals. It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity and can be a prognostic ...
Wenting Luo, Fang Xie, Zhongyu Zhang, Dawei Sun   +3 more
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Interfacial residues in protein-protein complexes are in the eyes of the beholder

Proteins: Structure, Function, and Bioinformatics, 2023
Abstract Interactions between proteins are vital in almost all biological processes. The characterization of protein-protein interactions helps us understand the mechanistic basis of biological processes, thereby enabling the manipulation of proteins for biotechnological and clinical purposes. The interface residues of a protein-protein
Jayadevan Parvathy, Arangasamy Yazhini, Narayanaswamy Srinivasan, Ramanathan Sowdhamini   +3 more
openaire   +4 more sources

Coronavirus disease 19 (COVID-19) and viral keratouveitis – unraveling the mystery

Indian Journal of Ophthalmology, 2023
To demonstrate viral proteins/inflammatory cytokines in a patient with unilateral keratouveitis. Retrospective case report. A 70-year-old Asian-Indian male presented with acute onset of blurring of vision in the left eye (OS) of 2 days duration.
Srinivasan Sanjay, Gairik Kundu, Vrushali Deshpande, Swaminathan Sethu, Ruchika Agrawal, Arkasubhra Ghosh, Ankush Kawali, Padmamalini Mahendradas, Rohit Shetty   +8 more
doaj   +1 more source

Heat Shock Proteins in the Human Eye [PDF]

International Journal of Proteomics, 2010
Heat shock proteins (Hsps) are believed to primarily protect and maintain cell viability under stressful conditions such as those occurring during thermal and oxidative challenges chiefly by refolding and stabilizing proteins. Hsps are found throughout the various tissues of the eye where they are thought to confer protection from disease states such ...
Urbak, Lærke, Vorum, Henrik
openaire   +3 more sources

IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model [PDF]

, 2020
PURPOSE. While the association between the gut microbiome and the immune system has been studied in autoimmune disorders, little is known about ocular disease.
Choi, Se Hyun, IM, SIN HYEOG, Kim, Hye Min, Kim, Kwang Pyo, Kim, Mee Kum, Oh, Jae Won, Ryu, Jin Suk   +6 more
core   +1 more source

Investigation of Cas9 antibodies in the human eye

Nature Communications, 2022
Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum ...
Marcus A. Toral, Carsten T. Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G. Bassuk, Matthew H. Porteus, Vinit B. Mahajan   +8 more
doaj   +1 more source

Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins

Antioxidants, 2021
The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and ...
Ana Álvarez-Barrios, Lydia Álvarez, Montserrat García, Enol Artime, Rosario Pereiro, Héctor González-Iglesias   +5 more
doaj   +1 more source

The Eyes Absent proteins in development and in developmental disorders [PDF]

Biochemical Society Transactions, 2021
The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation ...
Upendra Kumar Soni, Kaushik Roychoudhury, Rashmi S. Hegde   +2 more
openaire   +2 more sources