Results 101 to 110 of about 1,306 (146)

Pathology of experimental autoimmune uveoretinitis in mice

Journal of Autoimmunity, 1990
The histopathology and immunopathology of murine experimental autoimmune uveoretinitis (EAU) following active immunization with the interphotoreceptor retinoid-binding protein (IRBP) were studied. The methods used included conventional light microscopy and immunoperoxidase staining.
C C, Chan, R R, Caspi, M, Ni, W C, Leake, B, Wiggert, G J, Chader, R B, Nussenblatt   +6 more
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Everolimus improves experimental autoimmune uveoretinitis

Experimental Eye Research, 2012
The efficacy and action mechanism of everolimus in the treatment of experimental autoimmune uveoretinitis (EAU) was analyzed. Disease was induced in B10.RIII mice by immunization with human interphotoreceptor-retinoid-binding protein peptide 161-180 (hIRBPp161-180). Everolimus was administered by oral gavage (5 mg/kg/d) beginning either two days before
Hennig, M., Bauer, D., Wasmuth, S., Busch, M., Walscheid, K., Thanos, S., Heiligenhaus, Arnd   +6 more
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Angiography of experimental autoimmune uveoretinitis with ultrastructural correlation

Graefe's Archive for Clinical and Experimental Ophthalmology, 1998
Indocyanine green (ICG) angiography has been used to evaluate posterior uveitis in the clinical setting, despite the shortage of data on possible pathological correlates of observed findings.We used both ICG angiography and fluorescein angiography to examine rats that developed a mild form of experimental autoimmune uveoretinitis (EAU) induced by ...
A A, Okada, H, Goto, T, Mizusawa, K, Morimoto, Y, Ebihara, M, Usui   +5 more
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The mouse as a model of experimental autoimmune uveoretinitis (EAU)

Current Eye Research, 1990
An EAU model has been developed in the mouse using the retinal soluble antigen (SAg), and the interphotoreceptor retinoid-binding protein (IRBP). Immunogenetic studies indicate that sensitivity to disease is H-2 dependent, but some data suggest that non-MHC genes may also contribute to the regulation of EAU.
R R, Caspi, C C, Chan, B, Wiggert, G J, Chader   +3 more
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Tissue Repair in the Iris in Experimental Autoimmune Uveoretinitis

Experimental and Molecular Pathology, 1995
Our previous work on rats with S-antigen-induced experimental autoimmune uveoretinitis showed iris tissue changes involving infiltration of inflammatory cells, destruction of the iris architecture, and breakdown of the blood-retinal barrier. The present study reports the remarkable ability of the iris to regenerate during the postinflammatory period ...
J, Wang, E, Essner, H, Shichi
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Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin

Experimental Eye Research, 2007
Statins, which are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are approved for cholesterol reduction and are commonly used to treat atherosclerosis and coronary artery disease. Statins may also be potent immunomodulatory agents and may be beneficial in the treatment of autoimmune diseases.
Hideo, Kohno, Tsutomu, Sakai, Saburo, Saito, Kiichiro, Okano, Kenji, Kitahara   +4 more
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Antigen-presenting Cells in Experimental Autoimmune Uveoretinitis

Experimental Eye Research, 1998
The present study attempts to identify the antigen-presenting cells in the retina, utilizing bone marrow-transplanted chimeric rats. Two types of chimeras were used: one produced by transplanting bone marrow cells from F1 hybrids of Lewis and Brown Norway (BN) into sublethally irradiated Brown Norway rats (LBN/F1-->BN), followed by adoptive transfer of
S, Ishimoto, J, Zhang, V K, Gullapalli, G, Pararajasegaram, N A, Rao   +4 more
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Experimental Autoimmune Uveoretinitis in the Rat and Mouse

Current Protocols in Immunology, 2003
AbstractExperimental autoimmune uveoretinitis (EAU) in rats and mice is a prototypic T cell‐mediated autoimmune disease that targets the neural retina and related tissues. The model is used to represent human sight‐threatening inflammatory eye diseases that are believed to have an autoimmune etiology, and to study basic mechanisms of tolerance and ...
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Intraocular cytokine quantification of experimental autoimmune uveoretinitis in rats

Ocular Immunology and Inflammation, 1998
Elevations of inflammatory cytokines have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU) in rats, although such analysis has relied on indirect methods of assessment such as measurement of mRNA content. In this study, we examined the feasibility of directly measuring cytokine concentrations in intraocular extracts ...
A A, Okada, J, Sakai, M, Usui, J, Mizuguchi   +3 more
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Retinal Leukocyte Behavior in Experimental Autoimmune Uveoretinitis of Rats

Experimental Eye Research, 1997
In vivo retinal leukocyte behavior in the experimental autoimmune uveoretinitis (EAU) of rats was investigated using acridine orange digital fluorography. The technique employed high resolution images obtained from a scanning laser ophthalmoscope (SLO) subsequent to staining with the fluorescent nuclear dye, acridine orange.
M, Hamada, Y, Ogura, K, Miyamoto, H, Nishiwaki, N, Hiroshiba, Y, Honda   +5 more
openaire   +2 more sources