Results 111 to 120 of about 1,306 (146)

Fas Expression and Apoptosis in Rats with Experimental Autoimmune Uveoretinitis

Japanese Journal of Ophthalmology, 2001
To evaluate Fas expression on CD4 and CD8 T cells in each organ at each stage of experimental autoimmune uveoretinitis (EAU) and apoptotic cells within EAU eyes.Rats were immunized with the uveitopathogenic peptide derived from interphotoreceptor retinoid-binding protein.
T, Abe, A, Nakajima, N, Satoh, S, Sakuragi   +3 more
openaire   +2 more sources

Experimental autoimmune uveoretinitis: a model system for immunointervention: a review

Current Eye Research, 1992
Experimental autoimmune uveoretinitis (EAU) is a useful model of human posterior uveitis and as such, permits the analysis of strategies for immuno-intervention. Modulation of the autoimmune response may be attempted at the stages of induction of EAU, during homing of autoreactive lymphocytes to the target organ, the retina, or during the effector ...
J V, Forrester, J, Liversidge, H S, Dua, A, Dick, F, Harper, P G, McMenamin   +5 more
openaire   +2 more sources

Inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin

Ocular Immunology and Inflammation, 1993
The crucial role of CD4(+) T cells in mediating uveitis is well recognized. One treatment strategy of non-infectious uveitis therefore seeks to inhibit T cell function. For that purpose the authors have evaluated the efficacy of Rapamycin (RAPA), an inhibitor of lymphocyte response to growth factors.
F G, Roberge, A, Kozhich, C C, Chan, D F, Martin, R B, Nussenblatt, M D, De Smet   +5 more
openaire   +2 more sources

Immunosuppression by Gramicidin S of Experimental Autoimmune Uveoretinitis, Pinealitis and Autoimmune Encephalomyelitis

Journal of Ocular Pharmacology and Therapeutics, 1990
Using an in vitro lymphocyte proliferation assay we screened several cyclic peptide antibiotics (bacitracin, oleandomycin, capreomycin, colistin, virginiamycin, and gramicidin S) for their immunosuppressive activity. Gramicidin S (GrS) was found to inhibit [3H]-thymidine incorporation into concanavalin A-stimulated and E coli lipopolysaccharide ...
S, Matsushima, T, Yoshitoshi, H, Shichi
openaire   +2 more sources

Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis

Japanese Journal of Ophthalmology, 1997
Tacrolimus and rapamycin both belong to a new family of immunosuppressants, immunophilin ligands, but the mechanisms by which they inhibit T cell activation are different. Therefore, we tested the immunosuppressive effects of combination therapy with low doses of tacrolimus and rapamycin on experimental autoimmune uveoretinitis (EAU) in rats.
E, Ikeda, N, Hikita, K, Eto, M, Mochizuki   +3 more
openaire   +2 more sources

Evidence for immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis

European Journal of Immunology, 1981
AbstractEvidence is presented for the involvement of immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis, an ocular inflammatory disease induced in Lewis rats by injection of the purified S antigen from bovine retina. Several parameters at various dates after immunization have been studied.
Y, de Kozak, J, Sainte-Laudy, J, Benveniste, J P, Faure   +3 more
openaire   +2 more sources

Genetic factors in susceptibility and resistance to experimental autoimmune uveoretinitis

Current Eye Research, 1992
Experimental autoimmune uveoretinitis (EAU) can be induced in susceptible stains of rats and mice by immunization with purified retinal antigens, and serves as a model for human uveitis. Because strong HLA associations have been noted in a number of human uveitic diseases, we investigated the role of major histocompatibility complex (MHC) vs.
R R, Caspi, C C, Chan, Y, Fujino, S, Oddo, F, Najafian, S, Bahmanyar, H, Heremans, R L, Wilder, B, Wiggert   +8 more
openaire   +2 more sources

Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression

International Ophthalmology, 1990
Experimental autoimmune uveoretinitis (EAU), a mostly T-cell dependent disease, was induced in laboratory animals by a single immunization with retinal extract or purified S-antigen in complete Freund's adjuvant. It can be prevented or suppressed by injections of either the autoantigen or monoclonal antibodies against the autoantigen.
Y, De Kozak, M, Mirshahi
openaire   +2 more sources

Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction

Japanese Journal of Ophthalmology, 2001
To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism. Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time.
T, Abe, A, Nakajima, N, Satoh, M, Ohkoshi, S, Sakuragi, A, Koizumi   +5 more
openaire   +2 more sources

The dissection of experimental autoimmune uveoretinitis

Immunology Today, 1990
Shigeaki Ohno, Naoki Kumagai
openaire   +1 more source