Results 131 to 140 of about 1,555 (179)
The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis
Progress in Retinal and Eye Research, 2008 Experimental autoimmune uveoretinitis (EAU) serves as an animal model for human uveitis. EAU is inducible in animals by peripheral immunization with proteins found in the retina that triggers an immune response which leads to tissue damage. This is coordinated by autoantigen specific CD4(+) T cells whose activation is accompanied by the infiltration of
David A Copland +2 more
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Angiographic abnormalities of experimental autoimmune uveoretinitis
Current Eye Research, 1996Experimental autoimmune uveoretinitis (EAU) is an invaluable animal model for studying inflammatory eye disease in humans. Indocyanine green (ICG) is a fluorescent dye that can be used to image both retinal and choroidal vessels. This study was performed to examined the retinal and choroidal vascular abnormalities of a rat model of EAU using ICG and ...
Miles Stanford, J Marshall
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Copolymer 1 inhibits experimental autoimmune uveoretinitis
Journal of Neuroimmunology, 2000Copolymer 1 (Cop 1) inhibits experimental allergic encephalomyelitis induced by a variety of myelin proteins, but has been found ineffective so far in inhibiting other experimental autoimmune diseases such as diabetes or arthritis. Here, we report for the first time that Cop I inhibits the development of experimental autoimmune uveoretinitis, induced ...
Chi-Chao Chan +2 more
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Effect of Sex Hormones on Experimental Autoimmune Uveoretinitis (EAU)
Immunological Investigations, 2003Sex hormones have been associated with the prevalence, susceptibility, and severity of autoimmune disease. Although the exact mechanism is unknown, sex hormones are reported to influence cytokine production, specifically by affecting the balance of Th1 and Th2 effector cells.
Ronald R Buggage +2 more
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Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction
Japanese Journal of Ophthalmology, 2001To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism. Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time.
Naoki Satoh +2 more
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Autoimmunity, 1999 The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats.
Qian Li, Bing Sun, Terrence P O'Brien
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Pathology of experimental autoimmune uveoretinitis in mice
Journal of Autoimmunity, 1990The histopathology and immunopathology of murine experimental autoimmune uveoretinitis (EAU) following active immunization with the interphotoreceptor retinoid-binding protein (IRBP) were studied. The methods used included conventional light microscopy and immunoperoxidase staining.
C C, Chan +6 more
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Everolimus improves experimental autoimmune uveoretinitis
Experimental Eye Research, 2012The efficacy and action mechanism of everolimus in the treatment of experimental autoimmune uveoretinitis (EAU) was analyzed. Disease was induced in B10.RIII mice by immunization with human interphotoreceptor-retinoid-binding protein peptide 161-180 (hIRBPp161-180). Everolimus was administered by oral gavage (5 mg/kg/d) beginning either two days before
Hennig, M. +6 more
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The mouse as a model of experimental autoimmune uveoretinitis (EAU)
Current Eye Research, 1990An EAU model has been developed in the mouse using the retinal soluble antigen (SAg), and the interphotoreceptor retinoid-binding protein (IRBP). Immunogenetic studies indicate that sensitivity to disease is H-2 dependent, but some data suggest that non-MHC genes may also contribute to the regulation of EAU.
R R, Caspi +3 more
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Angiography of experimental autoimmune uveoretinitis with ultrastructural correlation
Graefe's Archive for Clinical and Experimental Ophthalmology, 1998Indocyanine green (ICG) angiography has been used to evaluate posterior uveitis in the clinical setting, despite the shortage of data on possible pathological correlates of observed findings.We used both ICG angiography and fluorescein angiography to examine rats that developed a mild form of experimental autoimmune uveoretinitis (EAU) induced by ...
A A, Okada +5 more
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