Results 141 to 150 of about 2,739 (187)

The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis

Progress in Retinal and Eye Research, 2008
Experimental autoimmune uveoretinitis (EAU) serves as an animal model for human uveitis. EAU is inducible in animals by peripheral immunization with proteins found in the retina that triggers an immune response which leads to tissue damage. This is coordinated by autoantigen specific CD4(+) T cells whose activation is accompanied by the infiltration of
Kerr, EC, Copland, DA, Dick, AD, Nicholson, LB   +3 more
openaire   +5 more sources

Effect of Sex Hormones on Experimental Autoimmune Uveoretinitis (EAU)

Immunological Investigations, 2003
Sex hormones have been associated with the prevalence, susceptibility, and severity of autoimmune disease. Although the exact mechanism is unknown, sex hormones are reported to influence cytokine production, specifically by affecting the balance of Th1 and Th2 effector cells.
Ronald R, Buggage, Dawn M, Matteson, De Fen, Shen, Bing, Sun, Nadine, Tuaillon, Chi-Chao, Chan   +5 more
openaire   +4 more sources

TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1‐dependent autoimmune disease

European Journal of Immunology, 1993
AbstractMercuric chloride (HgCl2) injections protect (Lewis x Brown‐Norway) F1 (F1) rats against experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal S antigen (S‐Ag); in contrast HgCl2‐injected F1 rats develop EAU following transfer of lymph node (LN) cells from rats immunized with S‐Ag alone.
Saoudi, Abdelhadi, Kuhn, Joelle, Druet, Philippe, Bellon, Blanche, Huygen, Kris, De Kozak, Yvonne, Velu, Thierry, Goldman, Michel   +7 more
openaire   +4 more sources

Everolimus improves experimental autoimmune uveoretinitis

Experimental Eye Research, 2012
The efficacy and action mechanism of everolimus in the treatment of experimental autoimmune uveoretinitis (EAU) was analyzed. Disease was induced in B10.RIII mice by immunization with human interphotoreceptor-retinoid-binding protein peptide 161-180 (hIRBPp161-180). Everolimus was administered by oral gavage (5 mg/kg/d) beginning either two days before
Hennig, M., Bauer, D., Wasmuth, S., Busch, M., Walscheid, K., Thanos, S., Heiligenhaus, Arnd   +6 more
openaire   +3 more sources

Pathology of experimental autoimmune uveoretinitis in mice

Journal of Autoimmunity, 1990
The histopathology and immunopathology of murine experimental autoimmune uveoretinitis (EAU) following active immunization with the interphotoreceptor retinoid-binding protein (IRBP) were studied. The methods used included conventional light microscopy and immunoperoxidase staining.
C C, Chan, R R, Caspi, M, Ni, W C, Leake, B, Wiggert, G J, Chader, R B, Nussenblatt   +6 more
openaire   +2 more sources

Antigen-presenting Cells in Experimental Autoimmune Uveoretinitis

Experimental Eye Research, 1998
The present study attempts to identify the antigen-presenting cells in the retina, utilizing bone marrow-transplanted chimeric rats. Two types of chimeras were used: one produced by transplanting bone marrow cells from F1 hybrids of Lewis and Brown Norway (BN) into sublethally irradiated Brown Norway rats (LBN/F1-->BN), followed by adoptive transfer of
S, Ishimoto, J, Zhang, V K, Gullapalli, G, Pararajasegaram, N A, Rao   +4 more
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Angiography of experimental autoimmune uveoretinitis with ultrastructural correlation

Graefe's Archive for Clinical and Experimental Ophthalmology, 1998
Indocyanine green (ICG) angiography has been used to evaluate posterior uveitis in the clinical setting, despite the shortage of data on possible pathological correlates of observed findings.We used both ICG angiography and fluorescein angiography to examine rats that developed a mild form of experimental autoimmune uveoretinitis (EAU) induced by ...
A A, Okada, H, Goto, T, Mizusawa, K, Morimoto, Y, Ebihara, M, Usui   +5 more
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Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression

International Ophthalmology, 1990
Experimental autoimmune uveoretinitis (EAU), a mostly T-cell dependent disease, was induced in laboratory animals by a single immunization with retinal extract or purified S-antigen in complete Freund's adjuvant. It can be prevented or suppressed by injections of either the autoantigen or monoclonal antibodies against the autoantigen.
Y, De Kozak, M, Mirshahi
openaire   +2 more sources

Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis

Japanese Journal of Ophthalmology, 1997
Tacrolimus and rapamycin both belong to a new family of immunosuppressants, immunophilin ligands, but the mechanisms by which they inhibit T cell activation are different. Therefore, we tested the immunosuppressive effects of combination therapy with low doses of tacrolimus and rapamycin on experimental autoimmune uveoretinitis (EAU) in rats.
E, Ikeda, N, Hikita, K, Eto, M, Mochizuki   +3 more
openaire   +2 more sources

Rhodopsin-induced experimental autoimmune uveoretinitis: Dose-dependent clinicopathological features

Experimental Eye Research, 1988
We have studied the clinicopathological features of experimental autoimmune uveoretinitis (EAU) induced in Lewis rats by injection of different doses of rhodopsin and its illuminated form opsin. Rhodopsin consistently appears to be more pathogenic than opsin.
J J, Schalken, H J, Winkens, A H, van Vugt, P H, Bovée-Geurts, W J, de Grip, R M, Broekhuyse   +5 more
openaire   +2 more sources