Results 141 to 150 of about 1,555 (179)

Tissue Repair in the Iris in Experimental Autoimmune Uveoretinitis

Experimental and Molecular Pathology, 1995
Our previous work on rats with S-antigen-induced experimental autoimmune uveoretinitis showed iris tissue changes involving infiltration of inflammatory cells, destruction of the iris architecture, and breakdown of the blood-retinal barrier. The present study reports the remarkable ability of the iris to regenerate during the postinflammatory period ...
J, Wang, E, Essner, H, Shichi
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Antigen-presenting Cells in Experimental Autoimmune Uveoretinitis

Experimental Eye Research, 1998
The present study attempts to identify the antigen-presenting cells in the retina, utilizing bone marrow-transplanted chimeric rats. Two types of chimeras were used: one produced by transplanting bone marrow cells from F1 hybrids of Lewis and Brown Norway (BN) into sublethally irradiated Brown Norway rats (LBN/F1-->BN), followed by adoptive transfer of
S, Ishimoto, J, Zhang, V K, Gullapalli, G, Pararajasegaram, N A, Rao   +4 more
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Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin

Experimental Eye Research, 2007
Statins, which are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are approved for cholesterol reduction and are commonly used to treat atherosclerosis and coronary artery disease. Statins may also be potent immunomodulatory agents and may be beneficial in the treatment of autoimmune diseases.
Hideo, Kohno, Tsutomu, Sakai, Saburo, Saito, Kiichiro, Okano, Kenji, Kitahara   +4 more
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Experimental Autoimmune Uveoretinitis in the Rat and Mouse

Current Protocols in Immunology, 2003
AbstractExperimental autoimmune uveoretinitis (EAU) in rats and mice is a prototypic T cell‐mediated autoimmune disease that targets the neural retina and related tissues. The model is used to represent human sight‐threatening inflammatory eye diseases that are believed to have an autoimmune etiology, and to study basic mechanisms of tolerance and ...
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Intraocular cytokine quantification of experimental autoimmune uveoretinitis in rats

Ocular Immunology and Inflammation, 1998
Elevations of inflammatory cytokines have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU) in rats, although such analysis has relied on indirect methods of assessment such as measurement of mRNA content. In this study, we examined the feasibility of directly measuring cytokine concentrations in intraocular extracts ...
A A, Okada, J, Sakai, M, Usui, J, Mizuguchi   +3 more
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Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations

Journal of Autoimmunity, 2008
Experimental autoimmune uveoretinitis (EAU) is an animal model for human intraocular inflammatory disease. EAU is induced in B10.RIII mice by immunization with RBP-3 161-180 peptide and intraperitoneal pertussis toxin and is mediated by CD4 T cells that ...
Ben J E Raveney, David A Copland, Andrew D Dick   +2 more
exaly   +2 more sources

Retinal Leukocyte Behavior in Experimental Autoimmune Uveoretinitis of Rats

Experimental Eye Research, 1997
In vivo retinal leukocyte behavior in the experimental autoimmune uveoretinitis (EAU) of rats was investigated using acridine orange digital fluorography. The technique employed high resolution images obtained from a scanning laser ophthalmoscope (SLO) subsequent to staining with the fluorescent nuclear dye, acridine orange.
M, Hamada, Y, Ogura, K, Miyamoto, H, Nishiwaki, N, Hiroshiba, Y, Honda   +5 more
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Fas Expression and Apoptosis in Rats with Experimental Autoimmune Uveoretinitis

Japanese Journal of Ophthalmology, 2001
To evaluate Fas expression on CD4 and CD8 T cells in each organ at each stage of experimental autoimmune uveoretinitis (EAU) and apoptotic cells within EAU eyes.Rats were immunized with the uveitopathogenic peptide derived from interphotoreceptor retinoid-binding protein.
T, Abe, A, Nakajima, N, Satoh, S, Sakuragi   +3 more
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Experimental autoimmune uveoretinitis: a model system for immunointervention: a review

Current Eye Research, 1992
Experimental autoimmune uveoretinitis (EAU) is a useful model of human posterior uveitis and as such, permits the analysis of strategies for immuno-intervention. Modulation of the autoimmune response may be attempted at the stages of induction of EAU, during homing of autoreactive lymphocytes to the target organ, the retina, or during the effector ...
J V, Forrester, J, Liversidge, H S, Dua, A, Dick, F, Harper, P G, McMenamin   +5 more
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Inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin

Ocular Immunology and Inflammation, 1993
The crucial role of CD4(+) T cells in mediating uveitis is well recognized. One treatment strategy of non-infectious uveitis therefore seeks to inhibit T cell function. For that purpose the authors have evaluated the efficacy of Rapamycin (RAPA), an inhibitor of lymphocyte response to growth factors.
F G, Roberge, A, Kozhich, C C, Chan, D F, Martin, R B, Nussenblatt, M D, De Smet   +5 more
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