Results 31 to 40 of about 1,555 (179)
Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis
Frontiers in Immunology, 2023 Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease.
Izabela P. Klaska +10 more
doaj +1 more source
Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis. [PDF]
J Immunol, 2014 Experimental autoimmune uveoretinitis is a model for noninfectious posterior segment intraocular inflammation in humans. Although this disease is CD4(+) T cell dependent, in the persistent phase of disease CD8(+) T cells accumulate.
Boldison J +6 more
europepmc +2 more sources
Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells
Frontiers in Immunology, 2020 Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen.
Fauziyya Muhammad +9 more
doaj +1 more source
Clinical &Translational Immunology, Volume 12, Issue 12, 2023., 2023 Non‐infectious uveitis has a range of ocular and systemic autoimmune and autoinflammatory causes. When the retina is involved, blood‐retinal barrier breakdown can lead to vision loss. Specific cytokines stand out as promoting intraocular inflammation. This article reviews the involvement of inflammatory cytokines – including tumour necrosis factor (TNF)
Lisia Barros Ferreira +4 more
wiley +1 more source
Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. [PDF]
Am J Pathol, 2007 Macrophage responses are regulated by multiple secreted factors as well as by cell surface receptors, including the inhibitory signals resulting from ligation of myeloid CD200 receptors (CD200R) by the widely distributed CD200.
Copland DA +8 more
europepmc +2 more sources
European Journal of Organic Chemistry, Volume 2022, Issue 26, July 14, 2022., 2022 A guide to the chemist's toolbox for the stimulation of invariant natural killer (iNKT) cells. This Review encompasses the synthetic strategies for the preparation of the iNKT cell agonist α‐galactosylceramide (αGalCer), its TH1/TH2 skewing analogs, and other synthetic probes for the elucidation of mechanisms of αGalCer trafficking.
Cecilia Romanò, Mads H. Clausen
wiley +1 more source
Quantifying the Role of Stochasticity in the Development of Autoimmune Disease
Cells, 2020 In this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics.
Lindsay B. Nicholson +2 more
doaj +1 more source
Advances in exosome therapies in ophthalmology–From bench to clinical trial
Acta Ophthalmologica, Volume 100, Issue 3, Page 243-252, May 2022., 2022 Abstract During the last decade, the fields of advanced and personalized therapeutics have been constantly evolving, utilizing novel techniques such as gene editing and RNA therapeutic approaches. However, the method of delivery and tissue specificity remain the main hurdles of these approaches.
Amisha Sanghani +4 more
wiley +1 more source
Osteopontin Aggravates Experimental Autoimmune Uveoretinitis in Mice [PDF]
The Journal of Immunology, 2007 Abstract Human endogenous uveitis is a common sight-threatening intraocular inflammatory disease and has been studied extensively using a murine model of experimental autoimmune uveoretinitis (EAU). It is possibly mediated by Th1 immune responses.
Mizuki, Kitamura +11 more
openaire +2 more sources
Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update
European Journal of Clinical Investigation, Volume 51, Issue 8, August 2021., 2021 Abstract Background Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries ...
Elvis Hysa +7 more
wiley +1 more source