Results 31 to 40 of about 1,306 (146)
European Journal of Organic Chemistry, Volume 2022, Issue 26, July 14, 2022., 2022 A guide to the chemist's toolbox for the stimulation of invariant natural killer (iNKT) cells. This Review encompasses the synthetic strategies for the preparation of the iNKT cell agonist α‐galactosylceramide (αGalCer), its TH1/TH2 skewing analogs, and other synthetic probes for the elucidation of mechanisms of αGalCer trafficking.
Cecilia Romanò, Mads H. Clausen
wiley +1 more source
Osteopontin Aggravates Experimental Autoimmune Uveoretinitis in Mice [PDF]
The Journal of Immunology, 2007 Abstract Human endogenous uveitis is a common sight-threatening intraocular inflammatory disease and has been studied extensively using a murine model of experimental autoimmune uveoretinitis (EAU). It is possibly mediated by Th1 immune responses.
Mizuki, Kitamura +11 more
openaire +2 more sources
Advances in exosome therapies in ophthalmology–From bench to clinical trial
Acta Ophthalmologica, Volume 100, Issue 3, Page 243-252, May 2022., 2022 Abstract During the last decade, the fields of advanced and personalized therapeutics have been constantly evolving, utilizing novel techniques such as gene editing and RNA therapeutic approaches. However, the method of delivery and tissue specificity remain the main hurdles of these approaches.
Amisha Sanghani +4 more
wiley +1 more source
Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update
European Journal of Clinical Investigation, Volume 51, Issue 8, August 2021., 2021 Abstract Background Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries ...
Elvis Hysa +7 more
wiley +1 more source
Tfh Cells in Henoch-Schönlein Purpura (IgA Vasculitis): Current Concept. [PDF]
J Immunol ResHenoch‐Schönlein purpura (HSP) is an inflammatory condition affecting the small blood vessels, leading to organ damage and symptoms across various body systems, including skin, joints, and kidneys. The disease’s pathogenesis involves the deposition of immunoglobulin (Ig) A immune complexes in vessels, triggering inflammation and damage. Recent research
Huang J, Liu J, Hu Y, Zhang X, Zhang Q.
europepmc +2 more sources
Role of Janus Kinase (JAK) Inhibitor in Autoimmune Ocular Inflammation: A Systematic Review
Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021 Purpose. To evaluate the effectiveness of Janus kinase (JAK) inhibitors for the treatment of patients with autoimmune disease and associated inflammatory ocular diseases. Methods. We identified relevant literature by screening the MEDLINE, PubMed, and Cochrane databases for randomized controlled trials, cohort studies, case controls, and case reports ...
Ji Wen +6 more
wiley +1 more source
A Role for Folate in Microbiome‐Linked Control of Autoimmunity
Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021 The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis.
Christine Mölzer +4 more
wiley +1 more source
Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling. [PDF]
PLoS ONE, 2013 IL-17-producing CD4(+) T helper 17 (Th17) cells are pathogenic in a range of human autoimmune diseases and corresponding animal models. We now demonstrate that such T cells infiltrating the target organ during the induction of experimental autoimmune ...
Ben J E Raveney +2 more
doaj +1 more source
Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease. [PDF]
Immun Inflamm DisGroup A streptococcal M protein elicit antibody and T‐cell responses that cross react with cardiac and connective tissue proteins in the Rat Autoimmune Valvulitis (RAV) model of rheumatic heart disease. Bordetella pertussis Toxin induce a robust Th1 response that potentiates the autoimmune process in the RAV model A robust Th1/Th17 response was found ...
Rafeek RAM +6 more
europepmc +2 more sources
Osteopontin is a biomarker for early autoimmune uveoretinitis
Neural Regeneration Research, 2022 Osteopontin (OPN) is an extracellular matrix protein with a diverse range of functions, including roles in cell adhesion, migration, and immunomodulation, which are associated with the modulation of neuroinflammation in the central nervous system.
Jeongtae Kim +7 more
doaj +1 more source