Results 31 to 40 of about 2,739 (187)

Osteopontin Aggravates Experimental Autoimmune Uveoretinitis in Mice [PDF]

The Journal of Immunology, 2007
Abstract Human endogenous uveitis is a common sight-threatening intraocular inflammatory disease and has been studied extensively using a murine model of experimental autoimmune uveoretinitis (EAU). It is possibly mediated by Th1 immune responses.
Mizuki, Kitamura, Kazuya, Iwabuchi, Nobuyoshi, Kitaichi, Shigeyuki, Kon, Hirokuni, Kitamei, Kenichi, Namba, Kazuhiko, Yoshida, David T, Denhardt, Susan R, Rittling, Shigeaki, Ohno, Toshimitsu, Uede, Kazunori, Onoé   +11 more
openaire   +2 more sources

AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2‐STAT3 signaling pathway

Immunity, Inflammation and Disease, Volume 11, Issue 6, June 2023., 2023
Tapinarof ameliorates lupus development of MRL/lpr mice. Tapinarof inhibits the differentiation of Tfh cells. Tapinarof modulates JAK2‐STAT3 pathway to suppress Tfh cell differentiation. Abstract Background The aryl hydrocarbon receptor (AhR) is a critical regulator of the pathogenesis of autoimmune disorders.
Ying Zhang, Yanyan Pan, Peiyi Zhang, Fang Wang, Ying Han, Kailin Li, Wen Jiang, Jue Wang, Yun Luan, Qian Xin   +9 more
wiley   +1 more source

Colitis in a transgenic mouse model of autoimmune uveitis may be induced by neoantigen presentation in the bowel

Scientific Reports, 2023
Undifferentiated uveitis (intraocular inflammation, IOI) is an idiopathic sight-threatening, presumed autoimmune disease, accountable for ~ 10% of all blindness in the developed world.
C. Mölzer, Y.-H. Liu, E. Muckersie, I. P. Klaska, R. Cornall, H. M. Wilson, L. Kuffová, J. V. Forrester   +7 more
doaj   +1 more source

Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis

Frontiers in Immunology, 2023
Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease.
Izabela P. Klaska, Tian Yu, Tian Yu, Rosie Fordyce, Koju Kamoi, Koju Kamoi, Richard J. Cornall, Cristina Martin-Granados, Lucia Kuffova, Lucia Kuffova, John V. Forrester   +10 more
doaj   +1 more source

Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis

Clinical &Translational Immunology, Volume 12, Issue 12, 2023., 2023
Non‐infectious uveitis has a range of ocular and systemic autoimmune and autoinflammatory causes. When the retina is involved, blood‐retinal barrier breakdown can lead to vision loss. Specific cytokines stand out as promoting intraocular inflammation. This article reviews the involvement of inflammatory cytokines – including tumour necrosis factor (TNF)
Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith   +4 more
wiley   +1 more source

Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Frontiers in Immunology, 2020
Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen.
Fauziyya Muhammad, Priscilla N. Avalos, M. H. Mursalin, Jian-Xing Ma, Michelle C. Callegan, Michelle C. Callegan, Michelle C. Callegan, Darren J. Lee, Darren J. Lee, Darren J. Lee   +9 more
doaj   +1 more source

Chemical Biology of αGalCer: A Chemist's Toolbox for the Stimulation of Invariant Natural Killer T (iNKT) Cells

European Journal of Organic Chemistry, Volume 2022, Issue 26, July 14, 2022., 2022
A guide to the chemist's toolbox for the stimulation of invariant natural killer (iNKT) cells. This Review encompasses the synthetic strategies for the preparation of the iNKT cell agonist α‐galactosylceramide (αGalCer), its TH1/TH2 skewing analogs, and other synthetic probes for the elucidation of mechanisms of αGalCer trafficking.
Cecilia Romanò, Mads H. Clausen
wiley   +1 more source

Advances in exosome therapies in ophthalmology–From bench to clinical trial

Acta Ophthalmologica, Volume 100, Issue 3, Page 243-252, May 2022., 2022
Abstract During the last decade, the fields of advanced and personalized therapeutics have been constantly evolving, utilizing novel techniques such as gene editing and RNA therapeutic approaches. However, the method of delivery and tissue specificity remain the main hurdles of these approaches.
Amisha Sanghani, Petru Andriesei, Konstantinos N. Kafetzis, Aristides D. Tagalakis, Cynthia Yu‐Wai‐Man   +4 more
wiley   +1 more source

Quantifying the Role of Stochasticity in the Development of Autoimmune Disease

Cells, 2020
In this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics.
Lindsay B. Nicholson, Konstantin B. Blyuss, Farzad Fatehi   +2 more
doaj   +1 more source

Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update

European Journal of Clinical Investigation, Volume 51, Issue 8, August 2021., 2021
Abstract Background Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries ...
Elvis Hysa, Carlo Alberto Cutolo, Emanuele Gotelli, Greta Pacini, Carlotta Schenone, Elke O Kreps, Vanessa Smith, Maurizio Cutolo   +7 more
wiley   +1 more source