Results 21 to 30 of about 1,306 (146)

Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis [PDF]

Nature Communications
In Juvenile Idiopathic Arthritis (JIA), the most common childhood rheumatic disease, many patients also develop uveitis (JIA-uveitis), risking life-long vision loss. The mechanisms driving uveitis development in JIA remain understudied.
Bethany R. Jebson, Benjamin Ingledow, Vicky Alexiou, Jakub Kubiak, Persephone Jenkins, Yuxuan Meng, Melissa Kartawinata, Restuadi Restuadi, Wei-Yu Lin, Chris Wallace, Colin J. Chu, Ameenat Lola Solebo, Lucy R. Wedderburn, Elizabeth C. Rosser, On behalf of the CLUSTER consortium   +14 more
doaj   +2 more sources

Macrophage expression of P2X7 controls autoimmune uveitis [PDF]

Journal of Neuroinflammation
The release of danger-associated molecular patterns (DAMPs) such as ATP from stressed or damaged cells is a key initiator of sterile inflammation. In autoimmune diseases, extracellular ATP acts as a potent pro-inflammatory signal by activating the ...
Paul-Alexandre Déchelle-Marquet, Yueshen Che, Camille Roux, Frédéric Blond, Kaitryn E. Ronning, Sébastien Augustin, Pauline Lagouge-Roussey, Caroline Nous, Sara Touhami, Bahram Bodaghi, Jean Kanellopoulos, Sahil Adriouch, Xavier Guillonneau, Florian Sennlaub, Cécile Delarasse   +14 more
doaj   +2 more sources

Correction: Regulatory Effects of IFN-β on the Development of Experimental Autoimmune Uveoretinitis in B10RIII Mice.

PLoS ONE, 2011
Min Sun, Yan Yang, Peizeng Yang, Bo Lei, Liping Du, Aize Kijlstra   +5 more
doaj   +4 more sources

S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation. [PDF]

PLoS ONE, 2015
S100B is a Ca2+ binding protein and is typically associated with brain and CNS disorders. However, the role of S100B in an inflammatory situation is not clear.
Jennifer Niven, Joseph Hoare, Debbie McGowan, Gayathri Devarajan, Shigeyoshi Itohara, Monique Gannagé, Peter Teismann, Isabel Crane   +7 more
doaj   +1 more source

Colitis in a transgenic mouse model of autoimmune uveitis may be induced by neoantigen presentation in the bowel

Scientific Reports, 2023
Undifferentiated uveitis (intraocular inflammation, IOI) is an idiopathic sight-threatening, presumed autoimmune disease, accountable for ~ 10% of all blindness in the developed world.
C. Mölzer, Y.-H. Liu, E. Muckersie, I. P. Klaska, R. Cornall, H. M. Wilson, L. Kuffová, J. V. Forrester   +7 more
doaj   +1 more source

Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis

Frontiers in Immunology, 2023
Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease.
Izabela P. Klaska, Tian Yu, Tian Yu, Rosie Fordyce, Koju Kamoi, Koju Kamoi, Richard J. Cornall, Cristina Martin-Granados, Lucia Kuffova, Lucia Kuffova, John V. Forrester   +10 more
doaj   +1 more source

AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2‐STAT3 signaling pathway

Immunity, Inflammation and Disease, Volume 11, Issue 6, June 2023., 2023
Tapinarof ameliorates lupus development of MRL/lpr mice. Tapinarof inhibits the differentiation of Tfh cells. Tapinarof modulates JAK2‐STAT3 pathway to suppress Tfh cell differentiation. Abstract Background The aryl hydrocarbon receptor (AhR) is a critical regulator of the pathogenesis of autoimmune disorders.
Ying Zhang, Yanyan Pan, Peiyi Zhang, Fang Wang, Ying Han, Kailin Li, Wen Jiang, Jue Wang, Yun Luan, Qian Xin   +9 more
wiley   +1 more source

Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Frontiers in Immunology, 2020
Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen.
Fauziyya Muhammad, Priscilla N. Avalos, M. H. Mursalin, Jian-Xing Ma, Michelle C. Callegan, Michelle C. Callegan, Michelle C. Callegan, Darren J. Lee, Darren J. Lee, Darren J. Lee   +9 more
doaj   +1 more source

Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis

Clinical &Translational Immunology, Volume 12, Issue 12, 2023., 2023
Non‐infectious uveitis has a range of ocular and systemic autoimmune and autoinflammatory causes. When the retina is involved, blood‐retinal barrier breakdown can lead to vision loss. Specific cytokines stand out as promoting intraocular inflammation. This article reviews the involvement of inflammatory cytokines – including tumour necrosis factor (TNF)
Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith   +4 more
wiley   +1 more source

Quantifying the Role of Stochasticity in the Development of Autoimmune Disease

Cells, 2020
In this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics.
Lindsay B. Nicholson, Konstantin B. Blyuss, Farzad Fatehi   +2 more
doaj   +1 more source