Results 21 to 30 of about 2,739 (187)

AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis. [PDF]

PLoS ONE, 2012
We previously showed that adeno-associated virus 2 (AAV2) mediated subretinal delivery of human interferon-alpha (IFN-α) could effectively inhibit experimental autoimmune uveoretinitis (EAU).
Lichun Tian, Bo Lei, Ju Shao, Lin Wei, Aize Kijlstra, Peizeng Yang   +5 more
doaj   +2 more sources

Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease. [PDF]

Immun Inflamm Dis
Group A streptococcal M protein elicit antibody and T‐cell responses that cross react with cardiac and connective tissue proteins in the Rat Autoimmune Valvulitis (RAV) model of rheumatic heart disease. Bordetella pertussis Toxin induce a robust Th1 response that potentiates the autoimmune process in the RAV model A robust Th1/Th17 response was found ...
Rafeek RAM, Reynolds SL, Pandey M, McMillan DJ, Sriprakash KS, Good MF, Ketheesan N.   +6 more
europepmc   +2 more sources

Biopotency and surrogate assays to validate the immunomodulatory potency of extracellular vesicles derived from mesenchymal stem/stromal cells for the treatment of experimental autoimmune uveitis

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have been recognized as promising cytotherapeutics due to their demonstrated immunomodulatory effects in various preclinical models.
Gagandeep Kaur, Eun‐Hye Bae, Yu Zhang, Nicole Ciacciofera, Kyung Min Jung, Heather Barreda, Carol Paleti, Joo Youn Oh, Ryang Hwa Lee   +8 more
doaj   +2 more sources

Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. [PDF]

Br J Ophthalmol, 2007
In early S-antigen induced experimental uveitis (EAU), photoreceptor mitochondrial proteins are nitrated prior to macrophage infiltration of the retina, suggesting that oxidative stress is an initial event in the development of EAU. We attempted to detect the oxidative stress and localise it in the EAU retina.Lewis rats were immunised with S-antigen in
Rajendram R, Saraswathy S, Rao NA.
europepmc   +4 more sources

Tissue resident memory T cells populate the human uveal tract [PDF]

Scientific Reports
The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues.
Andrew D. Foers, Ian R. Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas MW. Buckley, Moustafa Attar, Soledad Aguilar-Munoa, Queen Pilapil, Maram EA. Abdalla Elsayed, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Kin Sheng Lim, Mark C. Coles, Jonathan P. Sherlock, Andrew D. Dick, Sarah E. Coupland, Stephen N. Sansom, David A. Copland, Christopher D. Buckley, Srilakshmi M. Sharma, ORBIT Consortium   +25 more
doaj   +3 more sources

Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis [PDF]

Nature Communications
In Juvenile Idiopathic Arthritis (JIA), the most common childhood rheumatic disease, many patients also develop uveitis (JIA-uveitis), risking life-long vision loss. The mechanisms driving uveitis development in JIA remain understudied.
Bethany R. Jebson, Benjamin Ingledow, Vicky Alexiou, Jakub Kubiak, Persephone Jenkins, Yuxuan Meng, Melissa Kartawinata, Restuadi Restuadi, Wei-Yu Lin, Chris Wallace, Colin J. Chu, Ameenat Lola Solebo, Lucy R. Wedderburn, Elizabeth C. Rosser, On behalf of the CLUSTER consortium   +14 more
doaj   +2 more sources

Macrophage expression of P2X7 controls autoimmune uveitis [PDF]

Journal of Neuroinflammation
The release of danger-associated molecular patterns (DAMPs) such as ATP from stressed or damaged cells is a key initiator of sterile inflammation. In autoimmune diseases, extracellular ATP acts as a potent pro-inflammatory signal by activating the ...
Paul-Alexandre Déchelle-Marquet, Yueshen Che, Camille Roux, Frédéric Blond, Kaitryn E. Ronning, Sébastien Augustin, Pauline Lagouge-Roussey, Caroline Nous, Sara Touhami, Bahram Bodaghi, Jean Kanellopoulos, Sahil Adriouch, Xavier Guillonneau, Florian Sennlaub, Cécile Delarasse   +14 more
doaj   +2 more sources

Correction: Regulatory Effects of IFN-β on the Development of Experimental Autoimmune Uveoretinitis in B10RIII Mice.

PLoS ONE, 2011
Min Sun, Yan Yang, Peizeng Yang, Bo Lei, Liping Du, Aize Kijlstra   +5 more
doaj   +4 more sources

S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation. [PDF]

PLoS ONE, 2015
S100B is a Ca2+ binding protein and is typically associated with brain and CNS disorders. However, the role of S100B in an inflammatory situation is not clear.
Jennifer Niven, Joseph Hoare, Debbie McGowan, Gayathri Devarajan, Shigeyoshi Itohara, Monique Gannagé, Peter Teismann, Isabel Crane   +7 more
doaj   +1 more source

Doyne lecture 2016:intraocular health and the many faces of inflammation [PDF]

, 2016
Dogma for reasons of immune privilege including sequestration (sic) of ocular antigen, lack of lymphatic and immune competent cells in the vital tissues of the eye has long evaporated.
A D Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AD Dick, AL Wang, AM Cuervo, AO Edwards, AV Ramanan, B Molins, BD Gelfand, BJ Raveney, BJ Raveney, C Broderick, C Cayrol, CE Janssen, CJ Calder, CJ Chu, CS Shi, CW Pugh, D Banerjee, D Luger, D Xu, DA Copland, DA Copland, DJ Kilmartin, DS Dace, EC Kerr, EC Kerr, EM Palsson-McDermott, EM Palsson-McDermott, F An, FY Liew, GJ Jaffe, GJ Wright, GJ Wright, GS Hageman, GS Hageman, H Keino, H Wen, H Xi, H Xu, HE Grossniklaus, HE Grossniklaus, HE Grossniklaus, HM Cherwinski, IJ Crane, J Liu, J Liu, JE Thorne, JG Hollyfield, JH Kempen, JM Skeie, JV Forrester, JV Forrester, JW Crabb, K Dastgheib, K Gocho, K Kaarniranta, K Nakahira, KH Sonoda, KM Murphy, KM Murphy, L Wei, M Chen, M Deckert, M Greter, MC Jenmalm, MC Killingsworth, MG Netea, MJ Robertson, N Hashida, N Kerur, N Mizushima, N Mizushima, N Yosef, NA Rao, O Tomkins-Netzer, P Zamiri, PA Perez-Mancera, R Medzhitov, R Osusky, RB Nussenblatt, RB Nussenblatt, RJ Klein, RR Caspi, RR Caspi, RW Lee, RW Read, RW Read, S Horie, S Preston, S Theodoropoulou, S Zhang, SB Su, SE Liyanage, SJ Clark, SK Mitter, SL Doyle, SL Doyle, SL Masters, SM Islam, SM Sharma, TA Ferguson, V Tarallo, W Ma, WA Tseng, WK Wu, WK Wu, WR Green, X Cao   +115 more
core   +5 more sources