Results 31 to 40 of about 61,922 (191)
Frontiers in Pharmacology, 2021 Growing studies are revealing the critical manifestations of influenza, dengue virus (DENV) infection, Zika virus (ZIKV) disease, and Ebola virus disease (EVD) as emerging infectious diseases.
Sajad Fakhri +4 more
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Vaccines for epidemic infections and the role of CEPI
Human Vaccines & Immunotherapeutics, 2017 The author reviews the foundation of the Coalition for Epidemic Preparedness and Innovations and the choices it has made for funding of vaccine development against epidemic diseases.
Stanley A. Plotkin
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Immunity, 2019 Promising vaccines and results from recent clinical trials of therapeutic antibodies against Ebola virus offer hope for an end to this devastating disease. We asked three investigators in the field to share their views on the remaining challenges and important future research directions as we work toward controlling Ebola virus infection.
openaire +2 more sources
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Journal of microbiology, epidemiology and immunobiology, 2016 Problems of etiology, taxonomy and nomenclature of filoviruses, epidemiology, morbidity with a little-known by Russian medics especially dangerous exotic infectious disease - Ebola fever are examined. Significant distinguishing features of 2013 - 2015 epidemic in West Africa were detected - along with its unprecedented length, a decline did not take ...
V. A. Markin, V. B. Pantyukhov
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Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Analysis of the Ebola with a fractional-order model involving the Caputo-Fabrizio derivative [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2023 This paper uses a fractional-order epidemic model to describe the transmission dynamics of the Ebola virus. The proposed model uses the fractional-order derivative in Caputo-Fabrizio’s sense. It calculates the time-independent solutions of the proposed
Nita H Shah, Kapil Chaudhary
doaj
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Mental health effects of past and current pandemics on health-care professionals: A narrative review
Indian Journal of Social Psychiatry, 2023 During the coronavirus disease-19 (COVID-19) crisis, health-care workers (HCWs) across the world are facing a high risk of infection and increased workload. This makes them vulnerable to the psychological effects of the pandemic.
Kamaldeep Sadh +2 more
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Biotechnology Progress, EarlyView.Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg +8 more
wiley +1 more source