Results 41 to 50 of about 61,922 (191)

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia

Human Vaccines & Immunotherapeutics, 2017
Ebola hemorrhagic fever, also known as Ebola virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed the safety, side effects, and immunogenicity of a novel,
I. V. Dolzhikova, O. V. Zubkova, A. I. Tukhvatulin, A. S. Dzharullaeva, N. M. Tukhvatulina, D. V. Shcheblyakov, M. M. Shmarov, E. A. Tokarskaya, Y. V. Simakova, D. A. Egorova, D. N. Scherbinin, I. L. Tutykhina, A. A. Lysenko, A. V. Kostarnoy, P. G. Gancheva, T. A. Ozharovskaya, B. V. Belugin, L. V. Kolobukhina, V. B. Pantyukhov, S. I. Syromyatnikova, I. V. Shatokhina, T. V. Sizikova, I. G. Rumyantseva, A. F. Andrus, N. V. Boyarskaya, A. N. Voytyuk, V. F. Babira, S. V. Volchikhina, D. A. Kutaev, A. N. Bel'skih, K. V. Zhdanov, S. M. Zakharenko, S. V. Borisevich, D. Y. Logunov, B. S. Naroditsky, A. L. Gintsburg   +35 more
doaj   +1 more source

Dynamics of host-reservoir transmission of Ebola with spillover potential to humans

Electronic Journal of Qualitative Theory of Differential Equations, 2018
Ebola virus disease (EVD) is a zoonotic borne disease (i.e. disease that is spread from animals to people). Therefore human beings can be infected through direct contact with an infected animal (fruit-eating bat or great ape).
Berge Tsanou, Jean Lubuma, Arsène Jaurès Ouemba Tassé, Hervé Michel Tenkam   +3 more
doaj   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Resurgence of Sudan Virus Disease (SUVD) in Uganda

Global Biosecurity, 2022
On September 20th, 2022, a case of ebola virus disease was confirmed in Uganda by the World Health Organization. The presumed index case of a 24-year-old male was sequenced and identified as the Sudan strain. This was the first known outbreak of ebola in
Damian Alexander Honeyman, Adriana Notaras   +1 more
doaj   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Efficacy of control measures in the control of Ebola, Liberia 2014–2015

Journal of Biological Dynamics, 2018
The largest outbreak of Ebola to date is the 2014 West Africa Ebola outbreak, with more than 10,000 cases and over 4000 deaths reported in Liberia alone.
Necibe Tuncer, Chindu Mohanakumar, Samuel Swanson, Maia Martcheva   +3 more
doaj   +1 more source

The Art of Reception: Field Visits as Microcosms for Development Interventions of Non‐Governmental Organisations in Uganda

Journal of International Development, EarlyView.
ABSTRACT Field visits are common phenomena with non‐governmental organisations in Uganda. During these visits, Ugandan national staff guide visitors on series of meetings and interactions in the field. Following an actor‐oriented approach and drawing on ethnographic data on 14 field visits, this paper understands the field visit as a microcosm for the ...
Caspar Edward Swinkels
wiley   +1 more source

Mathematical modeling of the West Africa Ebola epidemic

eLife, 2015
As of November 2015, the Ebola virus disease (EVD) epidemic that began in West Africa in late 2013 is waning. The human toll includes more than 28,000 EVD cases and 11,000 deaths in Guinea, Liberia, and Sierra Leone, the most heavily-affected countries ...
Jean-Paul Chretien, Steven Riley, Dylan B George   +2 more
doaj   +1 more source

Urban wild meat and pangolin consumption across southern forested Cameroon: The limited influence of COVID‐19

People and Nature, EarlyView.
Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo, Ghislain F. Difouo, Christian N. Tchana, Alain Christel Wandji, Alfiery Laurel Djomnang‐Nkwala, Marcelle Mbadjoun Nziké, Sévilor Kekeunou, Markéta Swiacká, Daniel J. Ingram   +8 more
wiley   +1 more source