Results 111 to 120 of about 1,763,176 (361)

Commentary on the European Medicines Agency's extended mandate: Protecting public health in times of crisis and improving availability of medicines and medical devices

, 2023
British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 5-10, January 2023.
Inga Abed, Rosa Gonzalez‐Quevedo, Manuela Mura, Monica Dias, Silvy da Rocha Dias, Juan García Burgos   +5 more
wiley   +1 more source

Unusual Ebola Virus Chain of Transmission, Conakry, Guinea, 2014–2015

Emerging Infectious Diseases, 2016
In October 2015, a new case of Ebola virus disease in Guinea was detected. Case investigation, serology, and whole-genome sequencing indicated possible transmission of the virus from an Ebola virus disease survivor to another person and then to the case ...
Mory Keita, Sophie Duraffour, Nicholas J. Loman, Andrew Rambaut, Boubacar Diallo, Nfaly Magassouba, Miles W. Carroll, Joshua Quick, Amadou Sall, Judith R. Glynn, Pierre Formenty, Lorenzo Subissi, Ousmane Faye   +12 more
doaj   +1 more source

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

Vaccines, 2020
Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures
Huapeng Feng, Sumiho Nakatsu, Tiago Jose da Silva Lopes, Masaki Imai, Seiya Yamayoshi, Makoto Yamashita, Tokiko Watanabe, Yoshihiro Kawaoka   +7 more
doaj   +1 more source

Delayed Disease in Cynomolgus Macaques Exposed to Ebola Virus by an Intranasal Route

Frontiers in Immunology, 2021
Ebola virus remains a significant public health concern due to high morbidity and mortality rates during recurrent outbreaks in endemic areas. Therefore, the development of countermeasures against Ebola virus remains a high priority, and requires the ...
Sara C. Johnston, Catherine L. Wilhelmsen, Joshua Shamblin, Adrienne Kimmel, Justine Zelko, Suzanne Wollen, Arthur J. Goff   +6 more
doaj   +1 more source

Projections of Ebola outbreak size and duration with and without vaccine use in Équateur, Democratic Republic of Congo, as of May 27, 2018. [PDF]

, 2018
As of May 27, 2018, 6 suspected, 13 probable and 35 confirmed cases of Ebola virus disease (EVD) had been reported in Équateur Province, Democratic Republic of Congo. We used reported case counts and time series from prior outbreaks to estimate the total
Ackley, Sarah, Chen, Xianyun, Gao, Daozhou, Hoff, Nicole A, Kelly, J Daniel, Lietman, Thomas M, Mossoko, Mathais, Mukadi, Patrick, Muyembe-Tamfum, Jean Jacques, Okitolonda-Wemakoy, Emile, Porco, Travis C, Richardson, Eugene T, Rimoin, Anne W, Rutherford, George W, Selo, Bernice, Sinai, Cyrus, Wannier, S Rae, Worden, Lee   +17 more
core   +2 more sources

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

Cell Discovery, 2018
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need.
Shu Yang, Miao Xu, Emily M. Lee, Kirill Gorshkov, S. Shiryaev, Shihua He, Wei Sun, Yu‐Shan Cheng, Xin Hu, Anil M. Tharappel, Billy Lu, Antonella Pinto, Chen Farhy, Chun-Teng Huang, Zirui Zhang, Wenjun Zhu, Yuying Wu, Yi Zhou, Guang Song, Heng Zhu, K. Shamim, Carles Martínez-Romero, A. García-Sastre, R. Preston, D. Jayaweera, Ruili Huang, Wenwei Huang, M. Xia, A. Simeonov, G. Ming, X. Qiu, A. Terskikh, Hengli Tang, Hongjun Song, Wei Zheng   +34 more
semanticscholar   +1 more source

Virus-Vectored Ebola Vaccines [PDF]

Acta Naturae, 2017
The Ebola virus disease (EVD) is one of the most dangerous infections affecting humans and animals. The first EVD outbreaks occurred in 1976 in Sudan and Zaire. Since then, more than 20 outbreaks have occurred; the largest of which (2014-2016) evolved into an epidemic in West Africa and claimed the lives of more than 11,000 people. Although vaccination
Alexander L. Gintsburg, Denis Y. Logunov, A. I. Tukhvatulin, V. B. Pantyukhov, Dmitry V. Shcheblyakov, Borisevich Sv, Boris S. Naroditsky, O. L. Voronina, Inna V. Dolzhikova, L. V. Kolobukhina, Alina S. Dzharullaeva, Elizaveta A. Tokarskaya, V. F. Babira, S. I. Syromyatnikova   +13 more
openaire   +3 more sources

Molecular Tweezers for Biomimetic Recognition of Carbohydrates

ChemBioChem, EarlyView.
Molecular tweezers have emerged as effective binders for biomolecules such as lipids, nucleic acids, and proteins, eliciting biological activities. Tweezer molecules, which exploit an open and adaptive binding cavity, can target relatively large guests, such as oligosaccharides and glycans, and often provide some advantages over corresponding ...
Francesco Milanesi, Naufia Mohamedzakaria Shibinasbarveen, Stefano Roelens, Oscar Francesconi   +3 more
wiley   +1 more source

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

Contemporary Clinical Trials Communications, 2018
Introduction: This article describes a retrospective review of participant follow-up and retention strategies in the Partnership for Research on the Ebola Virus in Liberia (PREVAIL) I Vaccine Trial.
Sarah Browne, Tarweh Carter, Risa Eckes, Greg Grandits, Melvin Johnson, Irene Moore, Laura McNay   +6 more
doaj  

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

Viruses, 2018
The recent 2014–2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available ...
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A. Davey, Han Cheng, Lijun Rong   +8 more
doaj   +1 more source