Results 51 to 60 of about 67,833 (224)

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

Journal of Immunology Research, 2015
Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been
S. D. Dowall, V. A. Graham, K. Corbin-Lickfett, C. Empig, K. Schlunegger, C. B. Bruce, L. Easterbrook, R. Hewson   +7 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease

New England Journal of Medicine, 2021
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Mbala-Kingebeni, Placide, Pratt, Catherine, Ruffin, Mbusa Mutafali, Pauthner, Matthias G, Bile, Faustin, Ndaye, Antoine Nkuba, Black, Allison, Lusamaki, Eddy Kinganda, Faye, Martin, Aziza, Amuri, Diagne, Moussa M, Mukadi, Daniel, White, Bailey, Hadfield, James, Gangavarapu, Karthik, Bisento, Nella, Kazadi, Donatien, Nsunda, Bibiche, Akonga, Marceline, Tshiani, Olivier, Misasi, John, Ploquin, Aurelie, Epaso, Victor, Paka, Emilia Sana, N’kasar, Yannick Tutu Tshia, Mambu, Fabrice, Edidi, Francois, Matondo, Meris, Bula, Bula, Diallo, Boubacar, Keita, Mory, Belizaire, Marie Roseline Darnycka, Fall, Ibrahima Soce, Yam, Abdoulaye, Sabue, Mulangu, Rimion, Anne W, Salfati, Elias, Torkamani, Ali, Suchard, Marc A, Crozier, Ian, Hensley, Lisa, Rambaut, Andrew, Faye, Ousmane, Sall, Amadou, Sullivan, Nancy J, Bedford, Trevor, Andersen, Kristian G, Wiley, Michael R, Ahuka-Mundeke, Steve, Tamfum, Jean-Jacques Muyembe   +49 more
openaire   +5 more sources

Ebola Virus RNA in Semen from an HIV-Positive Survivor of Ebola

Emerging Infectious Diseases, 2017
Ebola virus is known to persist in semen of male survivors of Ebola virus disease (EVD). However, maximum duration of, or risk factors for, virus persistence are unknown.
Lawrence J. Purpura, Emerson Rogers, April Baller, Stephen White, Moses Soka, Mary J. Choi, Nuha Mahmoud, Christine Wasunna, Moses Massaquoi, Jomah Kollie, Straker Dweh, Philip Bemah, Victor Ladele, Jonathan Kpaka, Mary Jawara, Margaret Mugisha, Onyekachi Subah, Mylene Faikai, Jeff A. Bailey, Pierre E. Rollin, Barbara J. Marston, Tolbert G. Nyenswah, Alex Gasasira, Barbara Knust, Stuart T. Nichol, Desmond Williams   +25 more
doaj   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

Viruses, 2018
The recent 2014–2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available ...
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A. Davey, Han Cheng, Lijun Rong   +8 more
doaj   +1 more source

Urban wild meat and pangolin consumption across southern forested Cameroon: The limited influence of COVID‐19

People and Nature, EarlyView.
Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo, Ghislain F. Difouo, Christian N. Tchana, Alain Christel Wandji, Alfiery Laurel Djomnang‐Nkwala, Marcelle Mbadjoun Nziké, Sévilor Kekeunou, Markéta Swiacká, Daniel J. Ingram   +8 more
wiley   +1 more source

The Ebola outbreak in comparison: Liberia and Côte d’Ivoire [PDF]

, 2015
West Africa has been fighting its first epidemic of the Ebola virus disease for more thana year now. Despite a decline of infections, especially in urban centres, new cases stillemerge and call for continued vigilance.
Kaufmann, Andrea, Zanker, Franzisca, Heitz Tokpa, Katharina   +2 more
core  

Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences. [PDF]

, 2014
Understanding human filovirus hemorrhagic fever (FHF) clinical manifestations and evaluating treatment strategies require the collection of clinical data in outbreak settings, where clinical documentation has been limited.
Roddy, Paul, Nolte, Ellen, Matthias Borchert, Ellen Nolte, Paul Roddy, Borchert, Matthias, Bühler, Silja, Silja Bühler   +7 more
core   +1 more source