Results 81 to 90 of about 1,946,344 (262)

Unusual Ebola Virus Chain of Transmission, Conakry, Guinea, 2014–2015

Emerging Infectious Diseases, 2016
In October 2015, a new case of Ebola virus disease in Guinea was detected. Case investigation, serology, and whole-genome sequencing indicated possible transmission of the virus from an Ebola virus disease survivor to another person and then to the case ...
Mory Keita, Sophie Duraffour, Nicholas J. Loman, Andrew Rambaut, Boubacar Diallo, Nfaly Magassouba, Miles W. Carroll, Joshua Quick, Amadou Sall, Judith R. Glynn, Pierre Formenty, Lorenzo Subissi, Ousmane Faye   +12 more
doaj   +1 more source

Ebola, the killer virus [PDF]

Infectious Diseases of Poverty, 2015
Ebola virus disease (EVD) has mostly affected economically deprived countries as limited resources adversely affect a country's infrastructure and administration. Probing into the factors that led to the widespread outbreak, setting forth plans to counter EVD cases in developing countries, and devising definitive measures to limit the spread of the ...
Ghazanfar, Haider, Orooj, Fizza, Abdullah, Muhammad Ahmed, Ghazanfar, Ali   +3 more
openaire   +2 more sources

Testing Modeling Assumptions in the West Africa Ebola Outbreak [PDF]

, 2016
The Ebola virus in West Africa has infected almost 30,000 and killed over 11,000 people. Recent models of Ebola Virus Disease (EVD) have often made assumptions about how the disease spreads, such as uniform transmissibility and homogeneous mixing within ...
Burghardt, Keith, Hasne, Marie-Pierre, Huang, Junming, Ingram, Matthew, Song, Binyang, Verzijl, Christopher   +5 more
core   +3 more sources

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

Viruses, 2018
The recent 2014–2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available ...
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A. Davey, Han Cheng, Lijun Rong   +8 more
doaj   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Virus-Vectored Ebola Vaccines [PDF]

Acta Naturae, 2017
The Ebola virus disease (EVD) is one of the most dangerous infections affecting humans and animals. The first EVD outbreaks occurred in 1976 in Sudan and Zaire. Since then, more than 20 outbreaks have occurred; the largest of which (2014-2016) evolved into an epidemic in West Africa and claimed the lives of more than 11,000 people. Although vaccination
I V, Dolzhikova, E A, Tokarskaya, A S, Dzharullaeva, A I, Tukhvatulin, D V, Shcheblyakov, O L, Voronina, S I, Syromyatnikova, S V, Borisevich, V B, Pantyukhov, V F, Babira, L V, Kolobukhina, B S, Naroditsky, D Y, Logunov, A L, Gintsburg   +13 more
openaire   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

Vaccines, 2020
Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures
Huapeng Feng, Sumiho Nakatsu, Tiago Jose da Silva Lopes, Masaki Imai, Seiya Yamayoshi, Makoto Yamashita, Tokiko Watanabe, Yoshihiro Kawaoka   +7 more
doaj   +1 more source

Public health and public trust: Survey evidence from the Ebola Virus Disease epidemic in Liberia.

Social Science & Medicine (1967), 2017
Trust in government has long been viewed as an important determinant of citizens' compliance with public health policies, especially in times of crisis. Yet evidence on this relationship remains scarce, particularly in the developing world.
R. Blair, Benjamin S. Morse, Lily L. Tsai   +2 more
semanticscholar   +1 more source