Results 251 to 260 of about 12,455 (266)
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2020
Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Catalino S. Demetria +2 more
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Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Catalino S. Demetria +2 more
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Immune Evasion in Ebolavirus Infections
Viral Immunology, 2015Ebola virus (EBOV) infects humans as well as several animal species. It can lead to a highly lethal disease, with mortality rates approaching 90% in primates. Recent advances have deepened our understanding of how this virus is able to prevent the development of protective immune responses.
Gary P. Kobinger, Jonathan Audet
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International Immunology, 2022
Ebolavirus (EBOV) causes an extremely high mortality and prevalence disease called Ebola virus disease (EVD). There is only one glycoprotein (GP) on the virus particle surface, which mediates entry into the host cell.
Yang Liu +14 more
semanticscholar +1 more source
Ebolavirus (EBOV) causes an extremely high mortality and prevalence disease called Ebola virus disease (EVD). There is only one glycoprotein (GP) on the virus particle surface, which mediates entry into the host cell.
Yang Liu +14 more
semanticscholar +1 more source
ACS Infectious Diseases, 2022
It is often challenging for a single monoclonal antibody to cross-react equally with all species of a particular viral genus that are separated by time and geographies to ensure broad long-term global immunodiagnostic use.
L. Sherwood, A. Hayhurst
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It is often challenging for a single monoclonal antibody to cross-react equally with all species of a particular viral genus that are separated by time and geographies to ensure broad long-term global immunodiagnostic use.
L. Sherwood, A. Hayhurst
semanticscholar +1 more source
Peptides for Anti-Ebolavirus Vaccines
Current Drug Discovery Technologies, 2016Two main factors can affect the development of ebolavirus immunotherapeutics: the vast peptide commonality between ebolavirus and human proteins, and the high rate of spontaneous mutation of ebolavirus within its human host. Indeed, the viral versus human peptide overlap may represent a relevant source of autoimmune crossreactions following vaccination,
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Ebolavirus: An Overview of Molecular and Clinical Pathogenesis
2017Ebolaviruses cause severe, often fatal hemorrhagic fever in Central, East, and West Africa. Until recently, they have been viewed as rare but highly pathogenic infections with regional, but limited, global public health impact. This view has changed with the emergence of the first epidemic of Ebola hemorrhagic fever in West Africa.
Heinz Feldmann +2 more
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ELISA Methods for the Detection of Ebolavirus Infection
2017Ebola viruses are high-priority pathogens first discovered in rural Africa associated with sporadic outbreaks of severe hemorrhagic disease in humans and nonhuman primates. Little is known about the disease ecology or the prevalence of past exposure of human populations to any of the five species of the genus Ebolavirus. The use of immunologic means of
Thomas G. Ksiazek, Robert W. Cross
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Ebolavirus Hemorrhagic Fever and the Obstetric Patient
Pediatric and Developmental Pathology, 2015To the Editor, Ebola virus (EBOV) and Marburg virus (MARV) constitute the family Filoviridae that are enveloped, nonsegmented, negative-stranded RNA viruses of varying morphology. They are markedly contagious and fatal in close to 90% of cases in Africa.
Robert L. Goldenberg, Halit Pinar
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Nachrichten aus der Chemie, 2018
AbstractDas Ebolavirus, das vor drei Jahren Westafrika heimsuchte, ist ungewöhnlich in seinem Aufbau und seinen Funktionsmechanismen. Die Strukturforschung beginnt erst jetzt, die Details dieses tödlichen Krankheitserregers zu verstehen.
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AbstractDas Ebolavirus, das vor drei Jahren Westafrika heimsuchte, ist ungewöhnlich in seinem Aufbau und seinen Funktionsmechanismen. Die Strukturforschung beginnt erst jetzt, die Details dieses tödlichen Krankheitserregers zu verstehen.
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Clinical features and pathobiology of Ebolavirus infection
Journal of Autoimmunity, 2014There has clearly been a deluge of international press coverage of the recent outbreak of Ebolavirus in Africa and is partly related to the "fear factor" that comes across when one is confronted with the fact that once infected, not only is the speed of death in a majority of cases rapid but also the images of the cause of death such as bleeding from ...
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