Results 251 to 260 of about 13,687 (277)

Pseudotyped Viruses for Marburgvirus and Ebolavirus.

Advances in Experimental Medicine and Biology, 2023
Marburg virus (MARV) and Ebola virus (EBOV) of the Filoviridae family are the most lethal viruses in terms of mortality rate. However, the development of antiviral treatment is hampered by the requirement for biosafety level-4 (BSL-4) containment. The establishment of BSL-2 pseudotyped viruses can provide important tools for the study of filoviruses ...
Li Zhang, Shoutao Liu, Youchun Wang
semanticscholar   +3 more sources

A highly attenuated pan-filovirus VesiculoVax vaccine rapidly protects nonhuman primates against Marburg virus and three species of Ebolavirus.

Journal of Infectious Diseases, 2023
BACKGROUND The family Filoviridae consists of several virus members known to cause significant mortality and disease in humans. Among these, Ebola virus (EBOV), Marburg virus (MARV), Sudan virus (SUDV), and Bundibugyo virus (BDBV) are considered the ...
Courtney Woolsey, V. Borisevich, K. Agans, Rachel O'Toole, Karla A. Fenton, Mack B. Harrison, A. Prasad, D. Deer, Cheryl S. Gerardi, Nneka Morrison, R. Cross, J. Eldridge, Demetrius Matassov, T. Geisbert   +13 more
semanticscholar   +1 more source

Where is the elusive primary ebolavirus reservoir and how do we find It?

BioScience
An enduring mystery in Ebolavirus research is what host species maintain the virus in the wild. Despite the efforts of multiple research groups over decades, no primary reservoir has ever been identified.
Mekala Sundaram, N. Gottdenker, Patrick R Stephens   +2 more
semanticscholar   +1 more source

Immune Evasion in Ebolavirus Infections

Viral Immunology, 2015
Ebola virus (EBOV) infects humans as well as several animal species. It can lead to a highly lethal disease, with mortality rates approaching 90% in primates. Recent advances have deepened our understanding of how this virus is able to prevent the development of protective immune responses.
Jonathan, Audet, Gary P, Kobinger
openaire   +2 more sources

Rapid detection of Ebolavirus using isothermal recombinase‐aided amplification

Journal of Medical Virology
Ebolavirus disease (EVD) is an often‐lethal disease caused by the genus Ebolavirus (EBOV). Although vaccines are being developed and recently used, outbreak control still relies on a combination of various factors, including rapid identification of EVD ...
Arianna Ceruti, Martin Faye, M. Diagne, R. Kobialka, Sheila Makiala-Mandanda, O. Faye, O. Faye, A. E. El Wahed, Manfred Weidmann   +8 more
semanticscholar   +1 more source

Reston Ebolavirus in Macaques

2020
Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Ina L. Smith, Catalino Demetria, Shuetsu Fukushi   +2 more
openaire   +1 more source

Peptides for Anti-Ebolavirus Vaccines

Current Drug Discovery Technologies, 2016
Two main factors can affect the development of ebolavirus immunotherapeutics: the vast peptide commonality between ebolavirus and human proteins, and the high rate of spontaneous mutation of ebolavirus within its human host. Indeed, the viral versus human peptide overlap may represent a relevant source of autoimmune crossreactions following vaccination,
openaire   +2 more sources

Der Turmbau des Ebolavirus

Nachrichten aus der Chemie, 2018
AbstractDas Ebolavirus, das vor drei Jahren Westafrika heimsuchte, ist ungewöhnlich in seinem Aufbau und seinen Funktionsmechanismen. Die Strukturforschung beginnt erst jetzt, die Details dieses tödlichen Krankheitserregers zu verstehen.
openaire   +1 more source

Characterization of Ebolavirus Entry

2019
Ebola virus disease is a global concern given its periodic occurrence, high lethality, and rapid spread, coupled with a lack of approved therapeutics and vaccines. New tools are needed to gain fundamental insight into the virus life cycle, particularly entry and fusion of the viral envelope with the host membrane, and to combat the spread of the ...
openaire   +2 more sources

Zaire ebolavirus spreads across Africa

The Lancet Infectious Diseases, 2005
By studying the genetic sequences of ebolaviruses that caused outbreaks in equatorial Africa over the past three decades, a team of German and US researchers has concluded that the Zaire strain of ebolavirus (ZEBOV) has been slowly spreading across these regions rather than popping up as sporadic outbreaks. “Our analyses suggest that ZEBOV has recently
openaire   +1 more source