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The efficacy of poly-ICLC against Ebola-Zaire virus (EBOV) infection in mice and cynomolgus monkeys
Antiviral Research, 2019(Uploaded by Plazi for the Bat Literature Project) The potential protection of poly-ICLC (Hiltonol®) a double stranded RNA (dsRNA) against EBOV infection was assessed with prophylactic and therapeutic administration to wild type and TLR3-negative mice, and in non-human primates (NHPs) by measuring EBOL serum titers, survival extension, and serum liver ...
Jason Paragas, Andres M Salazar
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CD81 is a restriction factor of EBOV trVLP and is downregulated by EBOV GP and VP40
EBOV, a highly pathogenic filovirus, causes Ebola virus disease to humans with high case fatalities. A broad range of cell types are susceptible for EBOV infection. EBOV entry into host cells is mediated by the viral surface glycoprotein GP, which is also known to play roles in immune evasion by modulating cell surface receptors.openaire +3 more sources
International Journal of Biological Macromolecules
Ebola virus (EBOV), a highly lethal pathogen with significant epidemic potential, has evolved multiple mechanisms to counteract and disrupt the host immune responses, including the interferon (IFN) pathway. Epitranscriptomic regulation, such as N6-methyladenosine (m6A) modification, has been demonstrated to regulate the innate immune response during ...
Baoxin, Zhao +11 more
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Ebola virus (EBOV), a highly lethal pathogen with significant epidemic potential, has evolved multiple mechanisms to counteract and disrupt the host immune responses, including the interferon (IFN) pathway. Epitranscriptomic regulation, such as N6-methyladenosine (m6A) modification, has been demonstrated to regulate the innate immune response during ...
Baoxin, Zhao +11 more
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The Ebola virus (EBOV) is a filamentous RNA virus which causes severe hemorrhagic fever. It is one of the most dangerous known pathogens with a high fatality rate. Multiple outbreaks of EBOV have occurred since the 1970s with the most widespread outbreak starting in December 2013.
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Countermeasures to Address the Ebloa Virus (EBOV) Threat
Journal of Antivirals & Antiretrovirals, 2014openaire +1 more source
VSV-EBOV Induces Temporal and Dose-Dependent Transcriptional Responses in Non-human Primates
Frontiers in Virology, 2021Andrea Marzi +2 more
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