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Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
The Epstein-Barr virus (EBV) is an oncogenic Herpes virus involved in the induction of a variety of human tumours. It was the first virus found to encode microRNAs (miRNAs). MiRNAs are short, non-coding RNAs that in most cases negatively regulate gene expression at the post-transcriptional level.
Stephanie, Barth +2 more
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The Epstein-Barr virus (EBV) is an oncogenic Herpes virus involved in the induction of a variety of human tumours. It was the first virus found to encode microRNAs (miRNAs). MiRNAs are short, non-coding RNAs that in most cases negatively regulate gene expression at the post-transcriptional level.
Stephanie, Barth +2 more
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Identification of EBV transforming genes by recombinant EBV technology
Seminars in Cancer Biology, 2001Epstein-Barr virus (EBV) is able to infect primary B-lymphocytes but usually does not proceed to replicate more virions. Instead, EBV persists as an incomplete virus and expresses 12 gene products that transform the growth of these cells into continuously proliferating lymphoblastoid cell lines. Because EBV is associated with several human malignancies,
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Implications of EBV-Encoded and EBV-Related miRNAs in Tumors
Current Gene TherapyOver 90% of people are infected with the human g-herpesvirus known as the Epstein- Barr virus (EBV). Cancers, such as gastric carcinoma, non-Hodgkin’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s lymphoma, and Burkitt lymphoma, are thought to be linked with EBV. It is noteworthy that the first virus discovered that encodes microRNAs (miRNAs) was EBV,
Prankur Awasthi +3 more
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Virus Research, 2002
EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high lymphoma rates in immunosuppressed monkeys. In the study, the entire coding region of the Cyno-EBV LMP1 gene was cloned,
Sylvie, Faucher +2 more
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EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high lymphoma rates in immunosuppressed monkeys. In the study, the entire coding region of the Cyno-EBV LMP1 gene was cloned,
Sylvie, Faucher +2 more
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Targeting EBV in EBV-associated malignancies
2015Workshop 3: Virus Discovery and ...
Hui, KF, Chiang, AKS, Yeung, PL
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Science Translational Medicine
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus (Younis et al. , this issue).
Guy Gorochov, Alexis Mathian
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Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus (Younis et al. , this issue).
Guy Gorochov, Alexis Mathian
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EBV-Directed T Cell Therapeutics for EBV-Associated Lymphomas
2016Epstein Barr virus (EBV) is a human gamma herpes virus that establishes latency in B cells after primary infection. EBV generally only causes a mild, self-limiting viral illness but is also associated with several malignancies including posttransplantation lymphoproliferative disorder in the immunosuppressed host as well as Hodgkin and non-Hodgkin ...
Lauren P, McLaughlin +3 more
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2001
The Epstein-Barr virus (EBV) can choose between two alternative life styles. It infects B lymphocytes, transforming them into lymphoblastoid lines and, in contrast to neurotropic herpesviruses such as herpes simplex virus type I that establish latency in nondividing neurons, must maintain its latent genomes in cells that have the potential to divide ...
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The Epstein-Barr virus (EBV) can choose between two alternative life styles. It infects B lymphocytes, transforming them into lymphoblastoid lines and, in contrast to neurotropic herpesviruses such as herpes simplex virus type I that establish latency in nondividing neurons, must maintain its latent genomes in cells that have the potential to divide ...
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Understanding EBV infection and EBV-associated lymphomas in children
VirologyThe Epstein-Barr virus (EBV) infects over 90 % of the human population, often behaving as a harmless passenger in most hosts. However, since 1997, it has been classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC) due to its causal association with several malignancies. Most studies on EBV primary infection and EBV-
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