Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization [PDF]
, 2015 The use of time series profiling to identify groups of functionally related genes (synexpression groups) is a powerful approach for the discovery of gene function. Here we apply this strategy during RasV12 immortalization of Drosophila embryonic cells, a
Dequeant, M. L. +6 more
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A Drosophila ecdysone-deficient model to assess the endocrine disruptor activity of Bisphenol A
Ecotoxicology and Environmental SafetyBisphenol A (BPA) is a well characterized endocrine disruptor that interferes with the activity of a variety of nuclear receptors. For this reason, BPA has the potential to impact the function of the endocrine system and alter cellular physiology.
Patricia Vega-Cuesta +8 more
doaj +1 more source
Silencing of two insulin receptor genes disrupts nymph-adult transition of alate brown citrus aphid [PDF]
, 2017 Insulin receptors play key roles in growth, development, and polymorphism in insects. Here, we report two insulin receptor genes (AcInR1 and AcInR2) from the brown citrus aphid, Aphis (Toxoptera) citricidus.
Ding, Bi-Yue +7 more
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The ecdysteroidome of Drosophila: influence of diet and development [PDF]
, 2015 Ecdysteroids are the hormones regulating development, physiology and fertility in arthropods, which synthesize them exclusively from dietary sterols. But how dietary sterol diversity influences the ecdysteroid profile, how animals ensure the production ...
Carvalho, M. +6 more
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Anopheles gambiae blood feeding Initiates an anticipatory defense response to plasmodium berghei
, 2014 Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathogens. Much remains unknown about how different pathogens are sensed and specific responses triggered.
Christophides, GK +2 more
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The genome-wide transcriptional regulatory landscape of ecdysone in the silkworm
Epigenetics & Chromatin, 2018 Background The silkworm, Bombyx mori, a typical representative of metamorphic insects, is of great agricultural and economic importance. The steroid hormone ecdysone (20-hydroxyecdysone, 20E) is the central regulator of insect developmental transitions ...
Dong Cheng +7 more
doaj +1 more source
Mechanisms For The Environmental Regulation Of Gene Expression: Ecological Aspects Of Animal Development [PDF]
, 2005 The environment can play a significant role in the production of phenotypes. However, the developmental mechanisms by which the environmental agents effect normal development are Just becoming known. At least three paths have been found through which the
Gilbert, Scott F.
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Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines
G3: Genes, Genomes, Genetics, 2016 Steroid hormones induce cascades of gene activation and repression with transformative effects on cell fate . Steroid transduction plays a major role in the development and physiology of nearly all metazoan species, and in the progression of the most ...
Marcus Stoiber +4 more
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The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells [PDF]
, 2004 In Drosophila, activation of the apical caspase DRONC requires the apoptotic protease-activating factor homologue, DARK. However, unlike caspase activation in mammals, DRONC activation is not accompanied by the release of cytochrome c from mitochondria ...
Dorstyn, L. +3 more
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Matters of scale : positive allometry and the evolution of male dimorphisms [PDF]
, 2005 J.L.T. was funded by a Biotechnology and Biological Sciences Research Council research fellowship, J.S.K. by the Academy of Finland, and N.R.L. by a Natural Environment Research Council research fellowship.The developmental independence of alternative ...
Kotiaho, JS, LeBas, NR, Tomkins, JL
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