Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]
, 2016 Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M. +5 more
core +2 more sources
Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts
Advanced Science, Volume 12, Issue 39, October 20, 2025.This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu +8 more
wiley +1 more source
A Drosophila ecdysone-deficient model to assess the endocrine disruptor activity of Bisphenol A
Ecotoxicology and Environmental SafetyBisphenol A (BPA) is a well characterized endocrine disruptor that interferes with the activity of a variety of nuclear receptors. For this reason, BPA has the potential to impact the function of the endocrine system and alter cellular physiology.
Patricia Vega-Cuesta +8 more
doaj +1 more source
BMC Biology, 2018 Background Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpighian tubules; MTs), and how this
Wenjing Zheng +6 more
doaj +1 more source
The ecdysteroidome of Drosophila: influence of diet and development [PDF]
, 2015 Ecdysteroids are the hormones regulating development, physiology and fertility in arthropods, which synthesize them exclusively from dietary sterols. But how dietary sterol diversity influences the ecdysteroid profile, how animals ensure the production ...
Carvalho, M. +6 more
core +4 more sources
Memorias do Instituto Oswaldo Cruz, 2004 The effects of blood components, nerve-cord severance, and ecdysone therapy on the posterior midgut epithelial cells of 5th-instar Rhodnius prolixus nymphs 10 days after feeding were analyzed by transmission electron microscopy. Cutting the nerve-cord of
JM Albuquerque-Cunha +6 more
doaj +1 more source
microRNA-14 as an efficient suppressor to switch off ecdysone production after ecdysis in insects [PDF]
, 2019 Kang He +5 more
openalex +2 more sources
MicroRNA targets in Drosophila. [PDF]
, 2003 BACKGROUND: The recent discoveries of microRNA (miRNA) genes and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have set the stage for elucidation of a novel network of regulatory ...
Enright, Anton J +5 more
core +3 more sources
Developmental Expression of \u3cem\u3eDrop-Dead\u3c/em\u3e is Required for Early Adult Survival and Normal Body Mass in \u3cem\u3eDrosophila melanogaster\u3c/em\u3e [PDF]
, 2012 In Drosophila melanogaster, mutations in the gene drop-dead (drd) result in early adult lethality, with flies dying within 2 weeks of eclosion. Additional phenotypes include neurodegeneration, tracheal defects, starvation, reduced body mass, and female ...
Blumenthal, Edward M +1 more
core +1 more source
Anopheles gambiae blood feeding Initiates an anticipatory defense response to plasmodium berghei
, 2014 Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathogens. Much remains unknown about how different pathogens are sensed and specific responses triggered.
Christophides, GK +2 more
core +1 more source