β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway [PDF]
Frontiers in Cell and Developmental Biology, 2022 Bone defects are a global public health problem. However, the available methods for inducing bone regeneration are limited. The application of traditional Chinese herbs for bone regeneration has gained popularity in recent years. β-ecdysterone is a plant
Cai-Ping Yan +15 more
exaly +4 more sources
Urinary Elimination of Ecdysterone and Its Metabolites Following a Single-Dose Administration in Humans [PDF]
Metabolites, 2021 Ecdysterone is a phytosteroid widely discussed for its various pharmacological, growth-promoting, and anabolic effects, mediated by the activation of estrogen receptor beta (ERbeta).
Bernhard Wüst +2 more
exaly +4 more sources
Molecular insights into the role of Estrogen Receptor Beta in Ecdysterone Mediated Anabolic Activity [PDF]
PLoS ONEEcdysterone, often dubbed a “natural steroid,” has garnered significant attention among athletes for its reputed growth-promoting and anabolic properties.
Syeda Sumayya Tariq +6 more
doaj +5 more sources
Ecdysteroids: A novel class of anabolic agents? [PDF]
Biology of Sport, 2015 Increasing numbers of dietary supplements with ecdysteroids are marketed as “natural anabolic agents”. Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of
MK Parr +4 more
doaj +4 more sources
Sources of Environmental Exposure to the Naturally Occurring Anabolic Steroid Ecdysterone in Horses [PDF]
AnimalsEcdysterone controls moulting and reproduction in insects, crustaceans, and helminths. It is also produced by many plants, probably as an insect deterrent. The steroid is not made by vertebrates but has anabolic effects in mammals and could be useful for
Martin N. Sillence +5 more
doaj +2 more sources
Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing [PDF]
Journal of Orthopaedic Surgery and Research, 2021 Objectives To investigate the effects of β-ecdysterone on fracture healing and the underlying mechanism. Methods MTT assay was used to detect the cell viability. AO/PI and flow cytometry assays were used to determine the apoptotic rate.
Yanghua Tang +6 more
doaj +2 more sources
Simultaneous LC–MS Profiling of Bioactive Ecdysteroids in Nutrient-Dense Plant Sources and Dietary Supplements [PDF]
MoleculesPhytoecdysteroids have garnered increasing interest due to their broad biological and pharmacological properties. The present study reports on the development and validation of a reliable liquid chromatography–mass spectrometry method for the detection ...
Velislava Todorova +3 more
doaj +2 more sources
Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? [PDF]
CellsThe 20-hydroxyecdysone (20E) has been used in traditional medicine for a long time and acquired attention in the last decade as a food supplement and stimulant in physical activities.
Ernő Zádor
doaj +2 more sources
How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study [PDF]
Journal of the International Society of Sports NutritionIntroduction Phytosteroids like 20-hydroxyecdysone (20E) and diosgenin (DSG) have shown promising anabolic and performance-enhancing effects in in vitro, animal, and human studies.
Joshua Dissemond +8 more
doaj +2 more sources
Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy [PDF]
Frontiers in PharmacologyAchyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold and Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, and flavonoids.
Moon Nyeo Park +11 more
doaj +2 more sources