A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Sarcopenia is an age‐related skeletal muscle disorder characterized by loss of muscle mass and strength leading to mobility disability. 20‐Hydroxyecdysone (20E) is a polyhydroxylated plant steroid that demonstrates pharmacological effects in ...
Waly Dioh +8 more
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Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone [PDF]
Insects, 2023 20E (20-Hydroxyecdysone) is a central steroid hormone that orchestrates developmental changes and metamorphosis in arthropods. While its molecular mechanisms have been recognized for some time, detailed elucidation has primarily emerged in the past ...
Luobin Lin +4 more
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20-Hydroxyecdysone-responsive microRNAs of insects. [PDF]
RNA Biol, 2020 20-Hydroxyecdysone (20-HE) plays essential roles in coordinating developmental transitions of insects through responsive protein-coding genes and microRNAs (miRNAs).
Jin X, Wu X, Zhou L, He T, Yin Q, Liu S.
europepmc +5 more sources
20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1. [PDF]
BMC Biol, 2023 Background The regulation of glycolysis and autophagy during feeding and metamorphosis in holometabolous insects is a complex process that is not yet fully understood.
Kang XL +4 more
europepmc +2 more sources
Downregulation of CYP17A1 by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties [PDF]
Future Science OA, 2022 Aim: To investigate the effect of 20-hydroxyecdysone on steroidogenic pathway genes and plasma progesterone, and its potential impact on vascular functions.
Maneera Y Aljaber +11 more
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Krüppel-like factor 15 integrated autophagy and gluconeogenesis to maintain glucose homeostasis under 20-hydroxyecdysone regulation. [PDF]
PLoS Genet, 2022 The regulation of glycometabolism homeostasis is vital to maintain health and development of animal and humans; however, the molecular mechanisms by which organisms regulate the glucose metabolism homeostasis from a feeding state switching to a non ...
Wang XP +6 more
europepmc +2 more sources
20-Hydroxyecdysone (20E) signaling as a promising target for the chemical control of malaria vectors. [PDF]
Parasit Vectors, 2021 With the rapid development and spread of resistance to insecticides among anopheline malaria vectors, the efficacy of current World Health Organization (WHO)-approved insecticides targeting these vectors is under threat.
Ekoka E +4 more
europepmc +2 more sources
Phytomedicine Plus, 2021 Background: 20-hydroxyecdysone is an ecdysteroid which is abundant in plants and insects and has anabolic potentials in mammals. It was recently shown to have affinity for estrogen ER-β receptor, which could potentially make it vasodilatory.
Nelson N Orie +9 more
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Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? [PDF]
CellsThe 20-hydroxyecdysone (20E) has been used in traditional medicine for a long time and acquired attention in the last decade as a food supplement and stimulant in physical activities.
Ernő Zádor
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20-Hydroxyecdysone and Receptor Interplay in the Regulation of Hemolymph Glucose Level in Honeybee (Apis mellifera) Larvae [PDF]
Metabolites, 2023 The hormone 20-hydroxyecdysone (20E) and the ecdysone receptors (ECR and USP) play critical roles in the growth and metabolism of insects, including honeybees.
Jing Yu +6 more
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