Results 41 to 50 of about 1,564 (197)

Echinacoside Alleviates UVB Irradiation-Mediated Skin Damage via Inhibition of Oxidative Stress, DNA Damage, and Apoptosis [PDF]

, 2017
Ultraviolet B (UVB) irradiation has been known to cause skin damage, which is associated with oxidative stress, DNA damage, and apoptosis. Echinacoside is a phenylethanoid glycoside isolated from Herba Cistanches, which exhibits strong antioxidant ...
Hua Li, Li Yan, Jianbo Wang, Zhe Yu, Juanli Zhang, Aidong Wen, Xiayin Wang, Di Zhang, Chengtao Lu   +8 more
core   +1 more source

Echinacoside as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma: Mechanistic Insights from TP53/SLC7A11/GPX4 Pathway Modulation. [PDF]

Int J Mol Sci
Despite the known antitumor properties of echinacoside (ECH), its specific role and mechanism in hepatocellular carcinoma (HCC) require in-depth exploration.
Wang P, Lin J, Su D.
europepmc   +2 more sources

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Drug Design, Development and Therapy, 2015
This present study investigated the absorption kinetics of echinacoside (ECH) in situ and in vitro and its oral bioavailability in rats. Additional aim was to find an agent(s) to promote ECH absorption and oral bioavailability among two efflux proteins and three absorption promoters.ECH absorption behaviors were investigated by everted gut sac model in
Shen,Jin-Yang, Yang,Xiao-Lin, Yang,Zhong-Lin, Kou,Jun-Ping, Li,Fei   +4 more
openaire   +4 more sources

Evaluation of the Farming Potential of Echinacea Angustifolia DC. Accessions Grown in Italy by Root-Marker Compound Content and Morphological Trait Analyses

Plants, 2020
The Echinacea genus includes a number of species that are commercially employed for the preparation of herbal products. Echinacea angustifolia DC. is one of these and is widely used, mainly for its immunomodulating properties, as it contains a wide range
Nicola Aiello, Arianna Marengo, Fabrizio Scartezzini, Pietro Fusani, Barbara Sgorbini, Patrizia Rubiolo, Cecilia Cagliero   +6 more
doaj   +1 more source

Effects of Echinacoside on Ehrlich Carcinoma in Rats by Targeting Proliferation, Hypoxia and Inflammation

Cureus, 2023
Background and objectives Ehrlich solid carcinoma (ESC) is a type of tumor originating from a spontaneous mammary adenocarcinoma in mice. It is highly aggressive and fast-growing and can create a solid undifferentiated mass when inserted under the skin. This makes it an ideal model for assessing cancer biology and tumor immunology.
Alshehri, Afnan, Albuhayri, Aeshah, Alanazi, May, Althubaiti, Manal A, Aljehani, Raghad F, Alsharif, Fai I, Alatawi, Taghreed M, Albalawi, Shouq S, Khodir, Ahmed E, Al-Gayyar, Mohammed M   +9 more
openaire   +2 more sources

Echinacoside Suppresses Amyloidogenesis and Modulates F-actin Remodeling by Targeting the ER Stress Sensor PERK in a Mouse Model of Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2020
Endoplasmic reticulum stress (ERS) plays a vital and pathogenic role in the onset and progression of Alzheimer’s disease (AD). Phosphorylation of PKR-like endoplasmic reticulum kinase (PERK) induced by ERS depresses the interaction between actin-binding ...
Yuan Dai, Yuan Dai, Guanghui Han, Shijun Xu, Shijun Xu, Yongna Yuan, Chunyan Zhao, Tao Ma   +7 more
doaj   +1 more source

Safety and efficacy of feed additives consisting of dried extracts from Echinacea angustifolia DC. or Echinacea purpurea (L.) Moench for use in cats and dogs (C.I.A.M.)

EFSA Journal, 2021
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of dried extracts prepared from the dried roots of ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Johannes Westendorf, Paola Manini, Fabiola Pizzo, Birgit Dusemund   +22 more
doaj   +1 more source

Echinacoside Inhibits Osteoclast Function by Down-Regulating PI3K/Akt/C-Fos to Alleviate Osteolysis Caused by Periprosthetic Joint Infection

Frontiers in Pharmacology, 2022
Infected osteolysis as a common secondary osteoporosis is associated with excessive osteoclastogenesis and bone resorption. The inhibition of osteoclastogenesis and bone resorption have been demonstrated an effective approach in the treatment of ...
Tao Jiang, Tao Jiang, Hanwen Gu, Jian Wei   +3 more
doaj   +1 more source

Neuroprotective Effect of Echinacoside in Subacute Mouse Model of Parkinson’s Disease

BioMed Research International, 2019
Objective. To study the protective effect of Echinacoside for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopaminergic (DA) neurons injury in the subacute mouse model of Parkinson’s disease (PD) and to explore its mechanism of action. Methods.
Yan Liang, Chang Chen, Baomei Xia, Wei Wu, Juanjuan Tang, Qing Chen, Lili Tang, Hui Yang, Zhennian Zhang, Yan Lu, Ye Yang, Yang Zhao   +11 more
openaire   +2 more sources

<p>Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene</p>. [PDF]

Mol Med Rep
Asthenozoospermia (AZS) is one of the most common causes of male infertility, and the decreased expression and function of cation channel of sperm (CatSper) in the sperm contributes to the pathology of AZS. Phenylethanoid glycosides, such as echinacoside (ECH), a compound derived from Cistanche tubulosa, exhibit therapeutic potential for AZS.
Jin ZR, Huo YW, Liu BH, Tian H, Yuan S, Tian Y, Xi K, Cai J, Jiang H, Jiang Y, Xing GG.   +10 more
europepmc   +3 more sources