Results 71 to 80 of about 552 (147)

Comparative Study between the Hypoglycemic and Antioxidant Effects of Echinochrome on Type 1 and Type 2 Diabetes Mellitus

, 2020
Background: Diabetes mellitus (DM) is one of the five leading causes of death in the world and about six deaths per minute are attributable to diabetes complications.
Mas Marie, Mohamed As, AS A M Soliman, Mohamed *   +3 more
core  

Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats

, 2020
The present study was designed to evaluate the protective effects of echinochrome (Ech) on intrahepatic cholestasis in rats induced by a single (i.p.) injection of alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight).
Sohair R Fahmy (6624644), Nesreen Y Almortada (6624653), Amel M Soliman (6624650), Wafaa E Abd-El Aal (6624656), Dawlat A Sayed (6624647)   +4 more
core   +1 more source

The Teratogenic Mechanism of Echinochrome as a Hypoglycemic Agent on Wistar Rats [PDF]

The Open Biomarkers Journal, 2019
Background: Echinochrome (Ech) is the active ingredient in the Histochrome drug, which possesses strong antioxidant, hypolipidemic and hypoglycemic activity. Objective: The present work aimed to characterize the malformations induced by ...
Ayman S. Mohamed, Eman Y. Salah EL Din, Neveen A. Farag, Abdel Rahman A. Tawfik   +3 more
openaire   +1 more source

Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice

, 2021
Echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone) has been known to exhibit anti-oxidative and anti-inflammatory effects. However, no study has been carried out on the efficacy of Ech A against skin photoaging; this process is ...
Hyoung Kyu Kim, Bomin Seol, Jin Han, Jung Eun Seol, Sang Woo Ahn, Sergey A. Fedoreyev, Hyeong Rok Yun, Elena A. Vasileva, Nammi Park, Natalia P. Mishchenko, Valentin A. Stonik   +10 more
core   +1 more source

Echinochrome A inhibits epithelial–mesenchymal transition and induces cell death mediated by DNA damage in human triple-negative breast cancer cells

Journal of Functional Foods
Echinochrome A (Ech A), a marine-derived compound from Scaphechinus mirabilis, is known for its potent antioxidant activity. Its pharmacological derivative, Histochrome, is used to treat ischemia and cardiovascular disorders.
Soon Yong Park, Mi-So Jeong, Cong So Tran, Jinyoung Lee, Da-Young Eum, Seyeon Jung, Elena A. Vasileva, Seoung Rak Lee, Hyoung Kyu Kim, Natalia P. Mishchenko, Jin Han, Yoo Jin Choi, Si Ho Choi, Hwayoung Yun, Kyu Heo   +14 more
doaj   +1 more source

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells

Marine Drugs, 2019
Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability.
Ji Hye Park, Na-Kyung Lee, Hye Ji Lim, Sinthia Mazumder, Vinoth Kumar Rethineswaran, Yeon-Ju Kim, Woong Bi Jang, Seung Taek Ji, Songhwa Kang, Da Yeon Kim, Le Thi Hong Van, Ly Thanh Truong Giang, Dong Hwan Kim, Jong Seong Ha, Jisoo Yun, Hyungtae Kim, Jin Han, Natalia P. Mishchenko, Sergey A. Fedoreyev, Elena A. Vasileva, Sang Mo Kwon, Sang Hong Baek   +21 more
doaj   +1 more source

Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells

, 2019
Echinochrome A (Ech A), a natural pigment extracted from sea urchins, is the active ingredient of a marine-derived pharmaceutical called ‘histochrome’.
Hyoung Kyu Kim, Jin Han, Ye Young Shin, Yoojin Seo, Su-Jeong Oh, Ji Won Yang, Ji-Su Ahn, Sergey A. Fedoreyev, Hyung-Sik Kim, Natalia P. Mishchenko, Valentin A. Stonik   +10 more
core   +1 more source

Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets

, 2020
The effect of low doses of echinochrome A (EchA), a natural polyhydroxy-1,4-naphthoquinone pigment from the sea urchin Scaphechinus mirabilis, has been studied in clinical trials, when it was used as an active substance of the drug Histochrome® and ...
Larisa N. Bogdanovich, Aleksandr A. Artyukov, Tatyana A. Rutckova, Vyacheslav L. Novikov, Elena A. Zelepuga, Emma P. Kozlovskaya, Natalia M. Lupach   +6 more
core   +1 more source

Ηλεκτροϊνοποιημένες μικρο-/νανοΐνες ως συστήματα ελεγχόμενης αποδέσμευσης του εχινοχρώματος Α [PDF]

, 2023
Στα πλαίσια της παρούσας εργασίας πραγματοποιήθηκε απομόνωση της βιοδραστικής κόκκινης χρωστικής εχινόχρωμα Α από αχινούς του γένους Diadema που συλλέχθηκαν από τον κόλπο του Αγίου Γεωργίου στο Καστελλόριζο, σε βάθος 1-5 m, τον Σεπτέμβριο του 2021.
Μαυρογιώργης Παναγιώτης, Mavrogiorgis Panagiotis   +1 more
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New Aminonaphthoquinone from the Sea Urchins and

Natural Product Communications, 2016
The aminonaphthoquinone, spinamine E ( 5 ), was isolated for the first time from the sea urchins Strongylocentrotus pallidus (Sars G.O., 1872) and Mesocentrotus nudus (A. Agassiz, 1864). The structure of 5 was elucidated as 2-amino-3,5,6,7,8-pentahydroxy-
Elena A. Vasileva, Natalia P. Mishchenko, Pavel A. Zadorozhny, Sergey A. Fedoreyev   +3 more
doaj   +1 more source