Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice
PLoS Pathogens, 2021 Neonatal echovirus infections are characterized by severe hepatitis and neurological complications that can be fatal. Here, we show that expression of the human homologue of the neonatal Fc receptor (hFcRn), the primary receptor for echoviruses, and ...
Alexandra I Wells +2 more
exaly +3 more sources
Investigation and successful control of an echovirus 11 outbreak in neonatal intensive care units
Pediatrics and Neonatology, 2020 Background: Echovirus 11 emerged as a predominant enterovirus strain and was associated with neonatal mortalities in Taiwan in 2018. We investigated an echovirus 11 outbreak in the neonatal intensive care units (NICUs) in a tertiary hospital in northern ...
Chih-Jung Chen +2 more
exaly +3 more sources
Emergence of an echovirus 17 subtype causing a viral meningitis outbreak, Israel, 2025 to 2026 [PDF]
EurosurveillanceAn outbreak of enteroviral meningitis occurred in Israel between August 2025 and May 2026. Echovirus type 17 was identified in 72 hospitalised patients, most of them infants (n = 44).
Merav Weil
doaj +2 more sources
A novel post-mortem pathogen discovery program detects an outbreak of Echovirus E7: Uganda, 2022–2023 [PDF]
Frontiers in MicrobiologyObjectivesUtilizing post-mortem examination for routine monitoring of infectious diseases and pandemic preparedness is a common-sense, yet uncommon, public health measure.
Sonja L. Weiss +32 more
doaj +2 more sources
Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver. [PDF]
PLoS PathogensEnteroviruses are major causes of neonatal morbidity and mortality, with echovirus infections commonly associated with severe disease, including acute liver failure.
Emma Heckenberg +3 more
doaj +2 more sources
In Silico Saturation-Mutagenesis-Based Genomic Mutation Risk Assessment for Enterovirus B [PDF]
VirusesEnterovirus B (EVB) is the most prevalent species of human enteroviruses, responsible for a wide range of diseases, including hand, foot, and mouth disease, viral meningitis, myocarditis, and neonatal sepsis, imposing a significant disease burden ...
Linglin Wang +6 more
doaj +2 more sources
Diversity of lake bacteria promotes human echovirus inactivation [PDF]
Applied and Environmental MicrobiologyHuman enteric viruses can remain infective in surface waters for extended periods of time, posing a public health risk. Microbial activity contributes to the inactivation of waterborne enteric viruses, but while individual bacteria–virus interactions ...
Andrii Romanenko +4 more
doaj +2 more sources
Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway
Frontiers in Immunology, 2023 Among enteroviruses, echovirus can cause severe illnesses in neonates or infants, with high morbidity and mortality. Autophagy, a central component of host defense mechanisms, can function against diverse infections. In the present study, we investigated
Chunchen Wu +11 more
doaj +1 more source
Viruses, 2022 Here, we describe a small enterovirus outbreak including nine cases of aseptic meningitis in a New Zealand hospital in 2017. Most patients had a lymphocytic predominance in the CSF, their length of stay was short, and there were no paediatric cases or ...
Meik Dilcher +5 more
doaj +1 more source
Frontiers in Medicine, 2023 Echovirus 18 has been recognized as an important causative pathogen of aseptic meningitis in young children worldwide, and echovirus 18-induced meningitis is rarely found in adults with immunocompetence.
Chunmei Jiang +14 more
doaj +1 more source