Results 41 to 50 of about 10,160 (204)

Antiviral activity of a crude extract of Thalassia testudinum Banks ex König against the human enteroviruses echovirus 9 and coxsackievirus A16 [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Echovirus 9 (E9) and coxsackievirus A16 (CVA16) are etiological agents of aseptic meningitis and hand, foot, and mouth disease, respectively. Currently, there are no approved antiviral drugs against these viruses.
Liena de R. Ponce Rey, Rafael Frómeta Román, Elizabet Casanova Nodarse, Kethia González García, Luis F. Morier Díaz, Sonia Resik Aguirre, Idania Rodeiro Guerra   +6 more
doaj   +1 more source

Cytolytic Properties and Genome Analysis of Rigvir^® Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates

Viruses, 2022
Rigvir® is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. While it is claimed that Rigvir® causes cytolytic infection in several cancer cell lines, there is little molecular evidence for its oncolytic ...
Eero Hietanen, Marika K. A. Koivu, Petri Susi   +2 more
doaj   +1 more source

Infectious Entry Pathway of Enterovirus B Species

Viruses, 2015
Enterovirus B species (EV-B) are responsible for a vast number of mild and serious acute infections. They are also suspected of remaining in the body, where they cause persistent infections contributing to chronic diseases such as type I diabetes. Recent
Varpu Marjomäki, Paula Turkki, Moona Huttunen   +2 more
doaj   +1 more source

Pediatric Enteroviral Central Nervous System Infections in Bialystok, Poland: Epidemiology, Viral Types, and Drivers of Seasonal Variation

Viruses, 2020
Enteroviruses are common causes of infections of the central nervous system (CNS) that in temperate climates tend to peak in the summer. The aim of the study was to describe epidemiology, drivers of seasonality, and types of enteroviruses causing ...
Kacper Toczylowski, Magdalena Wieczorek, Ewa Bojkiewicz, Magdalena Wietlicka-Piszcz, Beata Gad, Artur Sulik   +5 more
doaj   +1 more source

A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier

mSphere, 2017
The blood-brain barrier (BBB) comprises the foremost protective barrier in the brain and is composed in part of a layer of microvascular endothelial cells that line the capillaries surrounding the brain.
John C. Bramley, Coyne G. Drummond, Nicholas J. Lennemann, Charles A. Good, Kwang Sik Kim, Carolyn B. Coyne   +5 more
doaj   +1 more source

Benefits and Harms of Herbal Medicines for Preventing and Treating Acute Respiratory Infections: An Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
Overview of systematic reviews evaluating the benefits and harms of herbal medicines for management of ARIs. ABSTRACT Hundreds of herbal medicines are currently marketed for the management of acute respiratory infections (ARIs). However, there is uncertainty about their benefits and harms, and clinical guidance remains unclear.
Fariba Aghajafari, Brian Choi, Devansh Bhatt, Susanna Maltoni, Elizabeth T. Thomas, Elena C. Rosca, Sara Gandini, Annette Plüddemann, Carl J. Heneghan, John M. Conly, Tom Jefferson, Igho J. Onakpoya   +11 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Localized exanthem due to echovirus 9.

, 2015
Exanthem caused by Echovirus 9.
Francesco Broccolo, Parodi, Aurora, Giulia Ciccarese, Javor, S, Francesco Drago, Ciccarese, Giulia, Drago, F, Ciccarese, G, Broccolo, Francesco, Javor, S., Parodi, A., Sanja Javor, Ciccarese, G., Toniolo, A, Drago, F., Aurora Parodi, Broccolo, F., Antonio Toniolo, Javor, Sanja, TONIOLO, ANTONIO, Drago, Francesco   +20 more
core   +1 more source

Echovirus reminder

Weekly releases (1997–2007), 2002
Countries which are experiencing recent or current epidemics of the kind reported in the Eurosurveillance Weekly report of 14 February entitled ‘Recent increases in incidence of echoviruses 13 and 30 around Europe’ (020214) are encouraged to contact Franky Lever (flever@phls.org.uk), who will be investigating enterovirus incidence in more detail as ...
openaire   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source