Results 1 to 10 of about 24,234 (207)

Rare But Specific B‐Cell Receptor Reactivity Against Coxsackievirus A24 in Primary Central Nervous System Lymphomas [PDF]

EJHaem
ABSTRACT Introduction Primary central nervous system lymphoma (PCNSL) remains a distinct and aggressive malignancy whose underlying antigenic triggers are largely unknown. While autoantigens such as neurabin‐I and SAMD14 have been implicated, the potential role of infectious agents in driving clonal B‐cell receptor selection within the central nervous ...
Kos I, Cetin O, Fadle N, Regitz E, Preuss K, Lohse S, Smola S, Hartmann S, Fend F, Klingel K, Scherer F, Schorb E, Bewarder M, Staber P, Thurner L.   +14 more
europepmc   +2 more sources

Coxsackievirus B Infections Are Associated With the Risk of Islet Autoimmunity in Children With Strong Genetic Susceptibility to Type 1 Diabetes-Results From the TRIGR Divia Study. [PDF]

Diabetes Metab Res Rev
ABSTRACT Aims Especially, the coxsackievirus B group of enteroviruses has been linked to the development of islet autoimmunity and type 1 diabetes in genetically susceptible individuals. Our aim was to study the possible associations of 10 different microbial infections with islet autoimmunity in a large international prospective study.
Oikarinen M, Sioofy-Khojine A, Puustinen L, Cuthbertson D, Lehtonen J, Jouppila NVV, Ludvigsson J, Hakola L, Niinistö S, Erlund I, Knip M, Krischer JP, Virtanen SM, Hyöty H, TRIGR Investigators.   +14 more
europepmc   +2 more sources

ASSOCIATION OF ANTI-COXSACKIE VIRUS-B IgG WITH AUTOANTIBODIES RELATED TO TYPE 1 DIABETES MELLITUS

The Iraqi Journal of Medical Sciences, 2022
Background: Coxsackievirus B is a virus may cause type 1 diabetes. There are links between Coxsackievirus B infections and type 1 diabetes. The presence of autoantibodies in pancreatic beta cells has been linked to the development of type 1 ...
Hakeem Gh. Hassan, Arwa M. Al-Shuwaikh, Raid K. Al-Auqili   +2 more
doaj   +9 more sources

Enteroviral infections are not associated with type 2 diabetes

Frontiers in Endocrinology, 2023
IntroductionFor more than a century, enteroviral infections have been associated with autoimmunity and type 1 diabetes (T1D). Uncontrolled viral response pathways repeatedly presented during childhood highly correlate with autoimmunity and T1D.
Huan Liu, Huan Liu, Shirin Geravandi, Shirin Geravandi, Ausilia Maria Grasso, Saheri Sikdar, Alberto Pugliese, Alberto Pugliese, Alberto Pugliese, Alberto Pugliese, Kathrin Maedler, Kathrin Maedler   +11 more
doaj   +1 more source

Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives

Frontiers in Chemistry, 2021
Cancer and viral infections continue to threaten humankind causing death worldwide. Hence, the discovery of new anticancer and antiviral agents still represents a major scientific goal.
Roberta Ibba, Sandra Piras, Paola Corona, Federico Riu, Roberta Loddo, Ilenia Delogu, Gabriella Collu, Giuseppina Sanna, Paola Caria, Tinuccia Dettori, Antonio Carta   +10 more
doaj   +1 more source

Development of antiviral therapeutics combating coxsackievirus type B3 infection

Инфекция и иммунитет, 2021
Enteroviruses comprise highly diverse group of single-stranded positive RNA viruses belonging to Enterovirus genus, Picornaviridae family. They are the most prevalent viruses worldwide highlighted by high resistance to environmental cues.
A. S. Volobueva, V. V. Zarubaev, K. S. Lantseva   +2 more
doaj   +1 more source

A Crucial Role of ACBD3 Required for Coxsackievirus Infection in Animal Model Developed by AAV-Mediated CRISPR Genome Editing Technique

Viruses, 2021
Genetic screens using CRISPR/Cas9 have been exploited to discover host–virus interactions. These screens have identified viral dependencies on host proteins during their life cycle and potential antiviral strategies.
Hye Jin Shin, Keun Bon Ku, Soojin Kim, Heon Seok Kim, Yeon-Soo Kim, Bum-Tae Kim, Seong-Jun Kim, Chonsaeng Kim   +7 more
doaj   +1 more source

Comparison of Monoclonal Gammopathies Linked to Poliovirus or Coxsackievirus vs. Other Infectious Pathogens

Cells, 2021
Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM).
Jean Harb, Nicolas Mennesson, Cassandra Lepetit, Maeva Fourny, Margaux Louvois, Adrien Bosseboeuf, Sophie Allain-Maillet, Olivier Decaux, Caroline Moreau, Anne Tallet, Eric Piver, Philippe Moreau, Valéry Salle, Edith Bigot-Corbel, Sylvie Hermouet   +14 more
doaj   +1 more source

TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing

Viruses, 2022
TRIM7 catalyzes the ubiquitination of multiple substrates with unrelated biological functions. This cross-reactivity is at odds with the specificity usually displayed by enzymes, including ubiquitin ligases.
Jakub Luptak, Donna L. Mallery, Aminu S. Jahun, Anna Albecka, Dean Clift, Osaid Ather, Greg Slodkowicz, Ian Goodfellow, Leo C. James   +8 more
doaj   +1 more source

Virus Infection Is an Instigator of Intestinal Dysbiosis Leading to Type 1 Diabetes

Frontiers in Immunology, 2021
In addition to genetic predisposition, environmental determinants contribute to a complex etiology leading to onset of type 1 diabetes (T1D). Multiple studies have established the gut as an important site for immune modulation that can directly impact ...
Zachary J. Morse, Marc S. Horwitz
doaj   +1 more source