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Antiviral Effects of Menthol on Coxsackievirus B [PDF]

Viruses, 2020
Coxsackievirus B (CVB) is a common human enterovirus that causes systemic infection but specifically replicates to high titers in the pancreas. It was reported that certain viruses induce mitochondrial fission to support infection. We documented that CVB
David J.R. Taylor, Syed M. Hamid, Allen M. Andres, Hannaneh Saadaeijahromi, Honit Piplani, Juliana F. Germano, Yang Song, Savannah Sawaged, Ralph Feuer, Stephen J. Pandol, Jon Sin   +10 more
doaj   +3 more sources

Coxsackievirus B Infections Are Associated With the Risk of Islet Autoimmunity in Children With Strong Genetic Susceptibility to Type 1 Diabetes-Results From the TRIGR Divia Study. [PDF]

Diabetes Metab Res Rev
ABSTRACT Aims Especially, the coxsackievirus B group of enteroviruses has been linked to the development of islet autoimmunity and type 1 diabetes in genetically susceptible individuals. Our aim was to study the possible associations of 10 different microbial infections with islet autoimmunity in a large international prospective study.
Oikarinen M, Sioofy-Khojine A, Puustinen L, Cuthbertson D, Lehtonen J, Jouppila NVV, Ludvigsson J, Hakola L, Niinistö S, Erlund I, Knip M, Krischer JP, Virtanen SM, Hyöty H, TRIGR Investigators.   +14 more
europepmc   +3 more sources

Novel Antiviral Activity of Ethyl 3-Hydroxyhexanoate Against Coxsackievirus B Infection [PDF]

Frontiers in Microbiology, 2022
Coxsackievirus group B (CVB) is a member of the genus Enterovirus in the family Picornaviridae. CVB infection has been implicated as a major etiologic agent of viral myocarditis, dilated cardiomyopathy, meningitis, and pancreatitis among children and ...
Oluwatayo Israel Olasunkanmi, James Mageto, Juval Avala Ntsigouaye, Ming Yi, Yanru Fei, Yang Chen, Sijia Chen, Weizhen Xu, Lexun Lin, Wenran Zhao, Yan Wang, Zhao-Hua Zhong   +11 more
doaj   +2 more sources

Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches [PDF]

Frontiers in Immunology, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Sichao Huang, Congcong Zhang, Jianing Li, Zongmao Dai, Jingjing Huang, Fengzhen Deng, Xumeng Wang, Xinxin Yue, Xinnan Hu, Yuxuan Li, Yushu Deng, Yanhang Wang, Wenran Zhao, Zhaohua Zhong, Yan Wang   +14 more
doaj   +2 more sources

Immune mechanisms of group B coxsackievirus induced viral myocarditis

Virulence, 2023
Viral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium ...
Yue Zhang, Xiaobin Zhou, Shuyi Chen, Xinchen Sun, Chenglin Zhou   +4 more
doaj   +2 more sources

Serology supportive of recent coxsackievirus B infection is correlated with multisystem inflammatory syndrome in children (MIS-C) [PDF]

Microbiology Spectrum
Rarely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will lead to myocarditis associated with multisystem inflammatory syndrome in children (MIS-C). It remains unclear why MIS-C only targets specific children.
Ramesh Kordi, Arthur J. Chang, Mark D. Hicar   +2 more
doaj   +2 more sources

Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets [PDF]

Cell Reports
Summary: Coxsackievirus B (CVB) is implicated as an environmental trigger for type 1 diabetes (T1D). While CVB impairs islet function and viability, its impact on individual primary human islet cell types remains unclear.
Daniel A. Veronese-Paniagua, Marlie M. Maestas, Diana C. Hernandez-Rincon, Kate E. Hinshaw, Matthew Ishahak, Jared P. Taylor, Hubert M. Tse, Jeffrey R. Millman   +7 more
doaj   +2 more sources

Rare But Specific B‐Cell Receptor Reactivity Against Coxsackievirus A24 in Primary Central Nervous System Lymphomas [PDF]

EJHaem
ABSTRACT Introduction Primary central nervous system lymphoma (PCNSL) remains a distinct and aggressive malignancy whose underlying antigenic triggers are largely unknown. While autoantigens such as neurabin‐I and SAMD14 have been implicated, the potential role of infectious agents in driving clonal B‐cell receptor selection within the central nervous ...
Kos I, Cetin O, Fadle N, Regitz E, Preuss K, Lohse S, Smola S, Hartmann S, Fend F, Klingel K, Scherer F, Schorb E, Bewarder M, Staber P, Thurner L.   +14 more
europepmc   +2 more sources

ASSOCIATION OF ANTI-COXSACKIE VIRUS-B IgG WITH AUTOANTIBODIES RELATED TO TYPE 1 DIABETES MELLITUS

The Iraqi Journal of Medical Sciences, 2022
Background: Coxsackievirus B is a virus may cause type 1 diabetes. There are links between Coxsackievirus B infections and type 1 diabetes. The presence of autoantibodies in pancreatic beta cells has been linked to the development of type 1 ...
Hakeem Gh. Hassan, Arwa M. Al-Shuwaikh, Raid K. Al-Auqili   +2 more
doaj   +9 more sources

Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells [PDF]

iScience, 2019
Summary: The group B Coxsackieviruses (CVB), belonging to the Enterovirus genus, can establish persistent infections in human cells. These persistent infections have been linked to chronic diseases including type 1 diabetes.
Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa   +11 more
doaj   +2 more sources