Results 41 to 50 of about 1,351 (168)

In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells.

PLoS ONE, 2013
Type 1 diabetes is characterized by autoimmune destruction of pancreatic beta cells. The role played by autoantibodies directed against beta cells antigens in the pathogenesis of the disease is still unclear. Coxsackievirus B infection has been linked to
Caterina Bason, Renata Lorini, Claudio Lunardi, Marzia Dolcino, Alessandro Giannattasio, Giuseppe d'Annunzio, Antonella Rigo, Nicoletta Pedemonte, Roberto Corrocher, Antonio Puccetti   +9 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine

Microorganisms, 2020
Coxsackievirus B (CVB) enteroviruses are common pathogens that can cause acute and chronic myocarditis, dilated cardiomyopathy, aseptic meningitis, and they are hypothesized to be a causal factor in type 1 diabetes.
Minna M. Hankaniemi, Mo A. Baikoghli, Virginia M. Stone, Li Xing, Outi Väätäinen, Saana Soppela, Amirbabak Sioofy-Khojine, Niila V. V. Saarinen, Tingwei Ou, Brandon Anson, Heikki Hyöty, Varpu Marjomäki, Malin Flodström-Tullberg, R. Holland Cheng, Vesa P. Hytönen, Olli H. Laitinen   +15 more
doaj   +1 more source

Myocarditis and fulminant hepatic failure from coxsackievirus B infection [PDF]

Postgraduate Medical Journal, 1985
Summary A case of fulminant hepatic failure in association with myocarditis is reported. Presentation suggested an acute hepatitis which was complicated by cardiac failure. Evidence of severe myocarditis was found at autopsy.
R B, Read, R J, Ede, P, Morgan-Capner, G, Moscoso, B, Portmann, R, Williams   +5 more
openaire   +2 more sources

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Monthly distribution of different subtypes of coxsackievirus B (CVB) isolated from environmental surveillance in Taiwan from July 2012 to December 2013.

, 2015
The positive isolates of the different subtypes of Coxsackievirus B are shown.
Ya-Fang Wang (439058), Sheng-Wen Huang (824653), Matthew C. Y. Lim (824652), Jen-Ren Wang (198419), Jyh-Yuan Yang (532172)   +4 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Construction of the Multi-Epitope HFMD Vaccine Based on an Attenuated CVB3 Vector and Evaluation of Immunological Responses in Mice

Vaccines
Background/Objectives: Hand, foot, and mouth disease (HFMD) is a major public health concern primarily caused by human enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), coxsackievirus A6 (CVA6), and certain coxsackievirus B serotypes.
Jiayi Zheng, Huixiong Deng, Zhuangcong Liu, Hengyao Zhang, Guangzhi Liu, Yanlei Li, Jiacheng Zhu, Liming Gu, Dongdong Qiao, Gefei Wang, Rui Li   +10 more
doaj   +1 more source

Involvement of Pattern Recognition Receptors in Coxsackievirus B Infection of Human Islets [PDF]

, 2013
T1DM is an autoimmune disease in which beta-cells are selectively destroyed by the immune system. As consequence of beta-cell destruction insulin levels decline resulting in elevated blood glucose levels.
Domsgen, Erna
core  

Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis

, 2008
Infection of mice with coxsackievirus B4 results within days in a severe acute necrotizing pancreatitis, which resolves completely within weeks. Gelatinase B or matrix metalloproteinase 9 (MMP-9) has previously been shown to be involved in several models
Armando M. De Palma, Philippe E. Van den Steen, Ghislain Opdenakker, De Palma, Armando M., Opdenakker, Ghislain, Neyts, Johan, Van den Steen, Philippe E., Ilse Van Aelst, Johan Neyts, Aelst, Ilse Van, Verbeken, Erik, Erik Verbeken   +11 more
core   +1 more source