Results 31 to 40 of about 1,351 (168)

Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes

open access: yesMicroorganisms, 2021
The thymus gland is a primary lymphoid organ for T-cell development. Various viral infections can result in disturbance of thymic functions. Medullary thymic epithelial cells (mTECs) are important for the negative selection of self-reactive T-cells to ...
Abdulaziz Alhazmi   +10 more
doaj   +1 more source

Meningo-encephalitis caused by Coxsackievirus group B type 2. Diagnosis confirmed by measuring intrathecal antibody

open access: yes, 1984
We describe a case of meningo-encephalitis caused by Coxsackievirus group B type 2. Diagnosis was suggested by isolation of virus from faeces and high titres of serum antibody in which Coxsackie virus B2 specific IgM antibody was detected.
Bailey, A. S.   +4 more
core   +1 more source

Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers. [PDF]

open access: yesPLoS Pathogens, 2014
Coxsackievirus B3 (CVB3), a member of the picornavirus family and enterovirus genus, causes viral myocarditis, aseptic meningitis, and pancreatitis in humans.
Scott M Robinson   +19 more
doaj   +1 more source

Antiviral and immunoregulatory effects of curcumin on coxsackievirus B3-infected hepatitis

open access: yesVirus Research, 2023
Fulminant hepatitis is a life-threatening complication of coxsackievirus B (CVB) 3 infections. The condition may deteriorate to disseminated intravascular coagulopathy with markedly increased liver enzymes, inflammatory cytokines, and chemokines, which ...
Yu-Jheng Lin   +6 more
doaj   +1 more source

Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change [PDF]

open access: yes, 2013
Fitting of atomic components into electron cryo-microscopy (cryoEM) density maps is routinely used to understand the structure and function of macromolecular machines.
Shakeel, S.   +10 more
core   +1 more source

Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018)

open access: yesЭпидемиология и вакцинопрофилактика, 2019
Relevance.  Annual elevation of enterovirus infection (EVI) incidence in the Russian Federation  as well as in the Sakhalin region determine  a necessity  of continuous  surveillance  involving molecular-genetic  methods  and  phylogenetic  analysis ...
E. Yu. Sapega   +4 more
doaj   +1 more source

Therapeutics for fulminant hepatitis caused by enteroviruses in neonates

open access: yesFrontiers in Pharmacology, 2022
Neonatal infection with nonpolio enteroviruses (EVs) causes nonspecific febrile illnesses and even life-threatening multiorgan failure. Hepatitis, which often results in hepatic necrosis followed by disseminated intravascular coagulopathy, is one of the ...
Li-Chiu Wang   +6 more
doaj   +1 more source

A novel microRNA promotes coxsackievirus B4 infection of pancreatic β cells

open access: yesFrontiers in Immunology
The epidemiological association of coxsackievirus B infection with type 1 diabetes suggests that therapeutic strategies that reduce viral load could delay or prevent disease onset.
Salima Lalani   +7 more
doaj   +1 more source

The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis

open access: yes, 1998
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in ...
Moncada, Salvador   +17 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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