Results 11 to 20 of about 12,288,625 (151)

Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells [PDF]

Molecular Therapy: Oncolytics, 2023
Primary drug resistance and minimal residual disease are major challenges in the treatment of B cell neoplasms. Therefore, this study aimed to identify a novel treatment capable of eradicating malignant B cells and drug-resistant disease.
Matthew Holmes, Gina B. Scott, Samuel Heaton, Tyler Barr, Basem Askar, Louise M.E. Müller, Victoria A. Jennings, Christy Ralph, Cathy Burton, Alan Melcher, Peter Hillmen, Christopher Parrish, Fiona Errington-Mais   +12 more
doaj   +2 more sources

Myocarditis, disseminated infection, and early viral persistence following experimental coxsackievirus B infection of cynomolgus monkeys. [PDF]

PLoS ONE, 2013
Coxsackievirus B (CVB) infection is a common cause of acute viral myocarditis. The clinical presentation of myocarditis caused by this enterovirus is highly variable, ranging from mildly symptoms to complete hemodynamic collapse.
Cheryl E Cammock, Nancy J Halnon, Jill Skoczylas, James Blanchard, Rudolf Bohm, Christopher J Miller, Chi Lai, Paul A Krogstad   +7 more
doaj   +3 more sources

Development of Group B Coxsackievirus as an Oncolytic Virus: Opportunities and Challenges

Viruses, 2021
Oncolytic viruses have emerged as a promising strategy for cancer therapy due to their dual ability to selectively infect and lyse tumor cells and to induce systemic anti-tumor immunity. Among various candidate viruses, coxsackievirus group B (CVBs) have
Huitao Liu, Honglin Luo
doaj   +2 more sources

The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis

, 1998
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in ...
Moncada, Salvador, Michelle Leppo, Richard Quick, Salvador Moncada, Foo Y. Liew, Wei, Xiao-Qing, Liew, Foo Y., Christopher Ocampo, Carlos Zaragoza, Charles J. Lowenstein, Ocampo, Christopher, Leppo, Michelle, Quick, Richard, Lowenstein, Charles J., Zaragoza, Carlos, Saura, Marta, Xiao-Qing Wei, Marta Saura   +17 more
core   +7 more sources

Replicase Gene of Coxsackievirus B3

, 1984
A cDNA copy covering two-thirds of the coxsackievirus B3 genomewas cloned in the PstI site of the pBR322 vector. A nucleotidesequence containing the gene for the viral replicase and the3' noncoding region of the coxsackievirus B3 genome was determined ...
Stålhanske, P.O.K., Pettersson, U., Lindberg, A Michael,   +2 more
core   +9 more sources

Identification of Immunogenic Epitopes That Permit the Detection of Antigen-Specific T Cell Responses in Multiple Serotypes of Group B Coxsackievirus Infections

Viruses, 2020
Coxsackievirus group B (CVB) contains six serotypes that can affect various organs. Some of these organ-specific diseases such as myocarditis and pancreatitis can be caused by more than one serotype.
Ninaad Lasrado, Arunakumar Gangaplara, Rajkumar Arumugam, Chandirasegaran Massilamany, Sayli Pokal, Yuzhen Zhou, Shi-Hua Xiang, David Steffen, Jay Reddy   +8 more
doaj   +1 more source

Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes. [PDF]

J Virol, 2017
Coxsackievirus B (CVB) is a common enterovirus that can cause various systemic inflammatory diseases. Because CVB lacks an envelope, it has been thought to be inherently cytolytic, wherein CVB can escape from the infected host cell only by causing it to ...
Sin J, McIntyre L, Stotland A, Feuer R, Gottlieb RA.   +4 more
europepmc   +2 more sources

QSAR studies of BBR analogues against coxsackievirus B1

Bulletin of the National Research Centre, 2022
Background Coxsackievirus group B (CVBs) are common enteroviruses associated with several diseases from etiologically to inflammatory cardiomyopathies and constitute a severe cause of mortality in newborn resulting in severe meningitis, fulminant ...
Babatunde Samuel Obadawo, Uchenna Asogwa, Abdualbaset Ahmed Ali   +2 more
doaj   +1 more source

Direct-Acting Antivirals and Host-Targeting Approaches against Enterovirus B Infections: Recent Advances

Pharmaceuticals, 2023
Enterovirus B (EV-B)-related diseases, which can be life threatening in high-risk populations, have been recognized as a serious health problem, but their clinical treatment is largely supportive, and no selective antivirals are available on the market ...
Chiara Tammaro, Michela Guida, Federico Appetecchia, Mariangela Biava, Sara Consalvi, Giovanna Poce   +5 more
doaj   +1 more source

IMB-0523 Inhibits Enterovirus 71 Replication by Activating Signal Transducer and Activator of Transcription 3 Signaling to Upregulate Interferon-Stimulated Genes Expression

Infectious Diseases & Immunity, 2023
. Background. Hand, foot, and mouth disease caused by enterovirus 71 (EV71) infection is prevalent in the Asia-Pacific region in recent years. Currently, no drug is available for the prevention and treatment of EV71 infection.
Huiqiang Wang, Miao Ge, Yanping Li, Yuhuan Li, Zhuorong Li   +4 more
doaj   +1 more source