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Implementation of Poliovirus Containment in Poliovirus Designated Facilities—United States, 2017–2024 [PDF]

Pathogens
As the world approaches wild poliovirus eradication, effective containment measures are essential to minimize the risk of a facility-associated reintroduction into a polio-free community.
Christy Ottendorfer, Patrick Vander Kelen, Cecelia A. Sanders, Emily Watson, Suganthi Suppiah, William Hoffman, Colby Sinclair, Abena Marfo, Lia Haynes Smith   +8 more
doaj   +2 more sources

Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses. [PDF]

Nature Communications, 2017
RNA viruses, such as poliovirus, have a great evolutionary capacity, allowing them to quickly adapt and overcome challenges encountered during infection.
Andino, Raul, Brodsky, Leonid, Dolan, Patrick Timothy, Farkov, Mikhail, Goldstein, Elizabeth Faul, Li, Min, Xiao, Yinghong   +6 more
core   +4 more sources

Research Progress Towards Poliovirus Virus-like Particle Vaccines: A Review [PDF]

Vaccines
Poliovirus (PV), a historically significant enterovirus responsible for severe paralytic diseases, has seen its incidence dramatically reduced through widespread vaccination efforts, propelling global eradication initiatives.
Taoli Han, Jinbo Xiao, Shiyao Zhang, Tongyue Su, Yinuo Liu, Yong Zhang   +5 more
doaj   +2 more sources

Evaluation of hyper-attenuated S19 poliovirus strains for use in poliovirus neutralization assays. [PDF]

PLoS ONE
Poliovirus eradication efforts have relied on effective vaccination campaigns and stringent laboratory containment of poliovirus strains. Serological testing is the primary means to address population immunity, vaccine efficacy, and individual poliovirus
Nicholas Wiese, William Hendley, Basit Jafri, Kathryn A V Jones, Giovanna Sifontes, Sandra Valdez, Yiting Zhang, Bernardo A Mainou   +7 more
doaj   +2 more sources

Development and Validation of a Quantitative RT-qPCR Panel for the Detection and Monitoring of Polioviruses in Wastewater Samples [PDF]

Microorganisms
Clusters of acute flaccid paralysis (AFP) caused by oral vaccine-derived poliovirus (VDPV) in 2022 and sporadic outbreaks in New York and Gaza highlight the ongoing risk of polio, alongside the persistent global threat posed by wild-type poliovirus. This
Linnet Immaraj, Judy Y. Qiu, Logan A. Brand, Tiejun Gao, Bonita Lee, Michael Parkins, Casey Hubert, Christine O’Grady, Xiaoli Pang   +8 more
doaj   +2 more sources

Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site [PDF]

Nature Communications
Poliovirus remains a serious threat to human health. Complete eradication of wild-type poliovirus has not yet succeeded, making the development of successful antivirals critical.
Benjamin T. Waddey, Andrew J. Charnesky, Julia E. Faust, Nadia M. DiNunno, Rama Devudu Puligedda, Sung Hyun Cho, Carol M. Bator, Steven D. Dong, Kutub Mahmood, Konstantin M. Chumakov, Scott K. Dessain, Susan L. Hafenstein   +11 more
doaj   +2 more sources

Surveillance of Acute Flaccid Paralysis (AFP) in Greece: 2008–2024 [PDF]

Pathogens
As part of the WHO’s Global Polio Eradication Initiative, acute flaccid paralysis (AFP) surveillance in children under 15 years old is crucial for monitoring the emergence of polioviruses and tracking Non-Polio Enteroviruses (NPEVs).
Stavroula Labropoulou, Theano Georgakopoulou, Vahid Baniasadi, Giota Mpizta, Stella Vorre, Maria Theodoridou, Mary Emmanouil, Emmanouil Angelakis   +7 more
doaj   +2 more sources

Direct detection of polioviruses using a recombinant poliovirus receptor.

PLoS ONE, 2021
Polioviruses are positive-sense, single-stranded RNA picornaviruses and the principal cause of poliomyelitis. Global poliovirus surveillance has relied on poliovirus isolation in cells, which may take a minimum of 10 days, involves maintaining two cell ...
Nancy Gerloff, Mark Mandelbaum, Hong Pang, Nikail Collins, Brittani Brown, Hong Sun, Chelsea Harrington, Jessica Hecker, Chadi Agha, Cara C Burns, Everardo Vega   +10 more
doaj   +2 more sources

Risk Assessment and Virological Monitoring Following an Accidental Exposure to Concentrated Sabin Poliovirus Type 3 in France, November 2018

Vaccines, 2020
The safe and secure containment of infectious poliovirus (PV) in facilities where live PV are handled is the condition to achieve and maintain poliomyelitis eradication.
Marion Jeannoël, Denise Antona, Clément Lazarus, Bruno Lina, Isabelle Schuffenecker   +4 more
doaj   +1 more source

Does IPV Boost Intestinal Immunity among Children under Five Years of Age? An Experience from Pakistan

Vaccines, 2023
The oral poliovirus vaccine (OPV) has been the mainstay of polio eradication, especially in low-income countries, and its use has eliminated wild poliovirus type 2.
Muhammad Atif Habib, Sajid Bashir Soofi, Imtiaz Hussain, Imran Ahmed, Zamir Hussain, Rehman Tahir, Saeed Anwar, Simon Cousens, Zulfiqar A. Bhutta   +8 more
doaj   +1 more source