Results 41 to 50 of about 88,319 (314)

Vaccine innovation, translational research and the management of knowledge accumulation [PDF]

, 2012
What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre, Archibugi, Aston, Baird, Baldwin, Bastien, Benison, Bentrup, Blume, Blume, Blume, Blume, Blume, Blume, Bodian, Bonu, Bryder, Burnet, Buse, Carter, Chase, Chataway, Connor, Constant, de Souza, Dosi, Douglas, Esparza, Feinberg, Fleck, Fujimura, Galambos, Gallagher, Garber, Gerschenkron, Girard, Griffin, Hacking, Hilleman, Hopkins, Hopkins, Hortsmann, IAVI, IOM, Kremer, Lanjouw, Marincola, Markel, Mays, McCoy, Mullan, Nelson, Nelson, Nichter, Nightingale, Nightingale, NIH, Ohid Yaqub, Ohka, Oshinsky, Paul, Paul Nightingale, Plotkin, Poltorak, Pérez-Cuevas, Racaniello, Rasti, Ren, Ridley, Robbins, Rogers, Rose, Rosenberg, Sabin, Schofield, Smith, Smith, Time, Time, Tomes, van Lente, Vernick, Vincenti, Weiss, West, Yaqub, Zinkernagel   +86 more
core   +2 more sources

Vaccine-related poliovirus shedding in trivalent polio vaccine and human immunodeficiency virus status: analysis from under five children

BMC Research Notes, 2017
Background Poliomyelitis is an acute viral infection caused by poliovirus and transmitted via the fecal–oral route. The causative agent is one of the three serotypes of poliovirus (serotypes 1, 2, 3) that differ slightly in capsid protein.
Joanne Hassan, Laura Wangai, Peter Borus, Christopher Khayeka–Wandabwa, Lucy Wanja Karani, Mercy Kithinji, Michael Kiptoo   +6 more
doaj   +1 more source

Poliovirus Vaccination Induces a Humoral Immune Response That Cross Reacts With SARS-CoV-2

Frontiers in Medicine, 2021
Background: Millions have been exposed to SARS-CoV-2, but the severity of resultant infections has varied among adults and children, with adults presenting more serious symptomatic cases.
Brittany A. Comunale, Lilly Engineer, Lilly Engineer, Yong Jiang, John C. Andrews, Qianna Liu, Lyuqing Ji, James T. Yurkovich, Roderick A. Comunale, Qiyi Xie   +9 more
doaj   +1 more source

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]

, 2012
All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude, Bartenschlager, Ralf, Chiramel, Abhilash, Chlanda, Petr, Habermann, Anja, Haselman, Uta, Hoppe, Simone, Kallis, Stephanie, Krijnse-Locker, Jacomine, Lee, Ji-Young, Merz, Andreas, Romero-Brey, Inés, Santarella-Mellwig, Rachel, Walther, Paul   +13 more
core   +3 more sources

Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication

Frontiers in Immunology, 2017
Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV).
A. Aghamohammadi, Hassan Abolhassani, N. Kutukculer, S. Wassilak, M. Pallansch, Samantha Kluglein, J. Quinn, R. Sutter, Xiaochuan Wang, O. Sanal, T. Latysheva, A. Ikinciogulları, E. Bernatowska, Irina A. Tuzankina, B. Costa-Carvalho, J. Franco, R. Somech, E. Karakoc‐Aydiner, Surjit Singh, L. Bezrodnik, F. Espinosa-Rosales, A. Shcherbina, Y. Lau, S. Nonoyama, F. Modell, V. Modell, Ahmet Andrea Anissa Armando Ayca Charu Deepti Deniz Dios Ozen Berlin Chouikha Partida-Gaytán Kiykim Prakash, M. Barbouche, M. Mckinlay   +28 more
semanticscholar   +1 more source

Antiviral Development for the Polio Endgame: Current Progress and Future Directions

Pathogens
As the world is approaching the eradication of wild poliovirus serotype 1, the last of the three wild types, the question of how to maintain a polio-free world becomes imminent.
Hang Xie, Eric E. Rhoden, Hong-Mei Liu, Folake Ogunsemowo, Bernardo A. Mainou, Rachel M. Burke, Cara C. Burns   +6 more
doaj   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E., Estes, M. K., Guix Arnau, Susana, Katayama, K., Sharp, T. M.   +4 more
core   +2 more sources

Prolonged Excretion of Poliovirus among Individuals with Primary Immunodeficiency Disorder: An Analysis of the World Health Organization Registry

Frontiers in Immunology, 2017
Individuals with primary immunodeficiency disorder may excrete poliovirus for extended periods and will constitute the only remaining reservoir of virus after eradication and withdrawal of oral poliovirus vaccine.
Grace R. Macklin, Yi Liao, Marina Takane, K. Dooling, S. Gilmour, O. Mach, O. Kew, R. Sutter, Ousmane Nicksy Gumede Raffaella Mohamed Francis Gloria Rey Diop Moeletsi Williams Seghier Delpeyroux Benito F   +8 more
semanticscholar   +1 more source

Establishment of a Poliovirus Containment Program and Containment Certification Process for Poliovirus-Essential Facilities, United States 2017–2022

Pathogens
Upon declaration of poliovirus (PV) type 2 eradication in 2015, the World Health Organization (WHO) published PV containment requirements in the Global Action Plan III (GAPIII) for mitigating the risk of a facility-associated release post eradication. In
Christy Ottendorfer, Bryan Shelby, Cecelia A. Sanders, Anna Llewellyn, Christy Myrick, Christye Brown, Suganthi Suppiah, Kortney Gustin, Lia Haynes Smith   +8 more
doaj   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, Nicky J., Evans, David J., Simmonds, Peter, Witteveldt, Jeroen   +3 more
core   +2 more sources