Results 61 to 70 of about 34,664 (179)

Will containment of wild poliovirus in laboratories and inactivated poliovirus vaccine production sites be effective for global certification?

Bulletin of the World Health Organization, 2004
The absolute laboratory containment of any virus cannot be guaranteed, but a wealth of experience indicates that effective containment of wild poliovirus materials for global certification is technically and operationally feasible.
Dowdle Walter R., Wolff Christopher, Sanders Raymond, Lambert Scott, Best Maureen   +4 more
doaj  

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Efficacy of commercial disinfectants Virkon®S and Microchem Plus against poliovirus

Journal of Biosafety and Biosecurity
Introduction: The WHO Global Action Plan for Poliovirus Containment, 4th edition (GAPIV) describes the necessary conditions for the containment of poliovirus material in poliovirus-essential facilities (PEFs).
Leesa Bruggink, David Bagnara, Yi Nong, Matthew Kaye, Linda Hobday, Jade McKenzie, Ann Cornish, Bruce Thorley, Chuan Kok Lim   +8 more
doaj   +1 more source

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye, Yashi Shi, Alexander Mustea, Xiaodan Mao, Pengming Sun   +4 more
wiley   +1 more source

An evaluation of the sensitivity of acute flaccid paralysis surveillance for poliovirus infection in Australia

BMC Infectious Diseases, 2009
Background World Health Organization (WHO) targets for acute flaccid paralysis (AFP) surveillance, including the notification of a minimum rate of AFP among children, are used to assess the adequacy of AFP surveillance for the detection of poliovirus ...
Madin Ben, Kelly Heath, Martin P Anthony J, Watkins Rochelle E, Watson Charles   +4 more
doaj   +1 more source

When Public Health Becomes the Weapon: Current and Prospective Consequences of the Genocide in Gaza

World Medical &Health Policy, Volume 18, Issue 2, June 2026.
ABSTRACT Catastrophic humanitarian conditions during the 2023–2025 genocide in Gaza have caused a public health crisis of exceptional magnitude. This article summarizes key short‐ and long‐term health consequences for Gaza's civilian population and outlines priorities for recovery.
Therese Alexandra Evald, Nanna Gram Ahlmark, Clara Barfod Parellada, Andreea Micula, Caroline Klint Johannesen, Dana Bdier, Fayez Mahamid, Hilde Lausund, Jane Brandt Sørensen, Maha Aon, Majd Qannita, Maren Johanne Heilskov Rytter, Nanna Maaløe, Nina Jøranson, Sara Aakre Faradonbeh, Vibeke Brix Christensen, Waseem Alzaanin, Sigurd Lauridsen, Helle Timm, Frederik Schou‐Juul   +19 more
wiley   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 6, Page 1078-1090, June 2026.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y‐Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon

Molecular Plant Pathology, Volume 27, Issue 6, June 2026.
A synonymous mutation at P1 K178 attenuates PVY virulence and abolishes tobacco vein necrosis. This attenuated vector serves as a high‐efficiency plant bioreactor for the production and purification of recombinant human interferons. ABSTRACT Plant virus‐based vectors are gaining significant attention as bioreactors for recombinant protein production ...
De‐Guo Liu, Yue‐Yue Wang, Qing Zhu, Xin‐Wei Huang, Xi‐Ying Yan, Meng‐Ao Jia, Yu‐Shuang Guo, Ling‐Gai Cao, Jun Jiang, Xiang‐Dong Li, Xiao‐Lian Zhang, Yan‐Ping Tian   +11 more
wiley   +1 more source

A RT-PCR method for selective amplification and phenotypic characterization of all three serotypes of Sabin-related polioviruses from viral mixtures

Memorias do Instituto Oswaldo Cruz, 2012
Outbreaks caused by vaccine-derived polioviruses are challenging the final eradication of paralytic poliomyelitis. Therefore, the surveillance of the acute flaccid paralysis cases based on poliovirus isolation and characterization remains an essential ...
Eliane Veiga da Costa, Renata de Mendonça Campos, Fernando Neto Tavares, Cátia Regina Valério Grégio, Fernanda Marcicano Burlandy, Edson Elias da Silva   +5 more
doaj   +1 more source