Results 71 to 80 of about 46,021 (228)

Environmental Surveillance of Poliovirus in the Democratic Republic of the Congo: Sensitivity and Site Productivity, 2017–2025

Pathogens
Background: Environmental surveillance (ES) of wastewater was introduced by the Global Polio Eradication Initiative (GPEI) to improve the sensitivity of acute flaccid paralysis (AFP) surveillance.
Vanessa Bakumba-Kiulu, Paul Tshiminyi-Munkamba, Trésor Kabeya-Mampuela, Meris Matondo-Kuamfumu, Grace Kashitu-Mujinga, Junior Bulabula-Penge, Elisabeth Pukuta-Nsimbu, Elysabeth Muyamuna-Mulongo, Yvonne Lay Mowele, Jean Claude Mukangala-Changa-Changa, Eddy Kinganda-Lusamaki, Narcisse Yogolelo-Riziki, Antoine Nkuba-Ndaye, Steve Ahuka-Mundeke   +13 more
doaj   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens

Risk Analysis, Volume 46, Issue 9, September 2026.
ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate
Jack F. Schijven, Peter F. M. Teunis, Walter Q. Betancourt   +2 more
wiley   +1 more source

An evaluation of the sensitivity of acute flaccid paralysis surveillance for poliovirus infection in Australia

BMC Infectious Diseases, 2009
Background World Health Organization (WHO) targets for acute flaccid paralysis (AFP) surveillance, including the notification of a minimum rate of AFP among children, are used to assess the adequacy of AFP surveillance for the detection of poliovirus ...
Madin Ben, Kelly Heath, Martin P Anthony J, Watkins Rochelle E, Watson Charles   +4 more
doaj   +1 more source

Mucosal immunity to poliovirus

Expert Review of Vaccines, 2011
The Global Polio Eradication Initiative (GPEI) currently based on use of oral poliovirus vaccine (OPV) has identified suboptimal immunogenicity of this vaccine as a major impediment to eradication, with a failure to induce protection against paralytic poliomyelitis in certain population segments in some parts of the world.
Pearay L, Ogra, Hiromasa, Okayasu, Cecil, Czerkinsky, Roland W, Sutter   +3 more
openaire   +2 more sources

A RT-PCR method for selective amplification and phenotypic characterization of all three serotypes of Sabin-related polioviruses from viral mixtures

Memorias do Instituto Oswaldo Cruz, 2012
Outbreaks caused by vaccine-derived polioviruses are challenging the final eradication of paralytic poliomyelitis. Therefore, the surveillance of the acute flaccid paralysis cases based on poliovirus isolation and characterization remains an essential ...
Eliane Veiga da Costa, Renata de Mendonça Campos, Fernando Neto Tavares, Cátia Regina Valério Grégio, Fernanda Marcicano Burlandy, Edson Elias da Silva   +5 more
doaj   +1 more source

Excretion and clearance of Sabin-like type 3 poliovirus in a child diagnosed with severe combined immunodeficiency

Human Vaccines & Immunotherapeutics
Children with primary immunodeficiency disorder (PID) are at higher risk of developing vaccine-associated paralytic poliomyelitis (VAPP) or vaccine-derived polioviruses (VDPV) infection when inadvertently expose to poliovirus vaccine, oral (OPV). A pilot
Ning Yao, Yang Liu, Zhi-Yong Zhang, Min Tian, Wu-Juan Xie, Hua Zhao, Hong Yang, Lance E. Rodewald, Ning Wen, Zun-Dong Yin, Fu-Zhen Wang, Qing Wang, Jia-Wei Xu   +12 more
doaj   +1 more source

Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site

Nature Communications
Poliovirus remains a serious threat to human health. Complete eradication of wild-type poliovirus has not yet succeeded, making the development of successful antivirals critical.
Benjamin T. Waddey, Andrew J. Charnesky, Julia E. Faust, Nadia M. DiNunno, Rama Devudu Puligedda, Sung Hyun Cho, Carol M. Bator, Steven D. Dong, Kutub Mahmood, Konstantin M. Chumakov, Scott K. Dessain, Susan L. Hafenstein   +11 more
doaj   +1 more source

Immune persistence after different polio sequential immunization schedules in Chinese infants

npj Vaccines
Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented since 2016, but no immune persistence data are
Ting Zhao, Jing Li, Teng Huang, Zhi-Fang Ying, Yan-Chun Che, Zhi-Mei Zhao, Yu-Ting Fu, Jun-Hui Tao, Qing-Hai Yang, Ding-Kai Wei, Guo-Liang Li, Li Yi, Yu-Ping Zhao, Hong-Bo Chen, Jian-Feng Wang, Rui-Ju Jiang, Lei Yu, Wei Cai, Wei Yang, Ming-Xue Xie, Qiong-Zhou Yin, Jing Pu, Li Shi, Chao Hong, Yan Deng, Lu-Kui Cai, Jian Zhou, Yu Wen, Hong-Sen Li, Wei Huang, Zhao-Jun Mo, Chang-Gui Li, Qi-Han Li, Jing-Si Yang   +33 more
doaj   +1 more source

Sporadic detection of vaccine-derived poliovirus type 2 using next-generation sequencing in Canadian wastewater in August of 2022

Scientific Reports
In July 2022, an unvaccinated young adult living in Rockland County, New York became paralyzed due to a vaccine-derived poliovirus type 2 (VDPV2) infection that was internationally transmitted. Wastewater surveillance in New York State uncovered VDPV2 in
Grace E. Seo, Russell Mandes, Nathan D. Wright, Justin P. Hawkins, Anneliese Landgraff, Ravinder Lidder, Umar Mohammed, Chand S. Mangat, Anne-Sophie Michel, Judith Fafard, Darian Hole, Andrea D. Tyler, Marli Vlok, Elsie Grudeski, Tim F. Booth, Anna Majer   +15 more
doaj   +1 more source