Results 31 to 40 of about 88,319 (314)

Emergence of vaccine-derived poliovirus type 2 after using monovalent type 2 oral poliovirus vaccine in an outbreak response, Philippines

Western Pacific Surveillance and Response, 2022
Objective: In response to an outbreak of circulating vaccine-derived poliovirus (cVDPV) type 2 in the Philippines in 2019–2020, several rounds of supplementary immunization activities using the monovalent type 2 oral poliovirus vaccine (OPV) were ...
SweetC B Alipon, Yoshihiro Takashima, Tigran Avagyan, Varja Grabovac, Syeda Kanwal Aslam, Benjamin Bayutas, Josephine Logronio, Xiaojun Wang, Achyut Shrestha, Sukadeo Neupane, Maria Concepcion Roces, Lea Necitas Apostol, Nemia Sucaldito   +12 more
doaj   +1 more source

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]

, 2011
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG, de Quadros, CA, Dowdle, WR, Foege, WH, Henderson, DA, John, TJ, Levine, MM   +6 more
core   +1 more source

Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, January 2018–June 2019

MMWR. Morbidity and mortality weekly report, 2019
Certification of global eradication of indigenous wild poliovirus type 2 occurred in 2015 and of type 3 in 2019. Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988 and broad use of live, attenuated oral poliovirus vaccine (OPV ...
J. Jorba, O. Diop, Jane Iber, Elizabeth Henderson, Kun Zhao, A. Quddus, R. Sutter, J. Vertefeuille, J. Wenger, S. Wassilak, M. Pallansch, C. Burns   +11 more
semanticscholar   +1 more source

PREVALENCE OF NEUTRALIZING ANTIBODIES AGAINST POLIOVIRUS 1, 2, AND 3 IN HEALTHCARE PROFESSIONALS AGED 20-50 YEARS

Revista Paulista de Pediatria, 2021
Objective: To describe the prevalence of neutralizing antibodies against poliovirus (PV1, PV2, and PV3) in blood samples of healthcare professionals aged 20 to 50 years.
José Cassio de Moraes, Maria Josefa Penon Rujula, Marcelo Otsuka   +2 more
doaj   +2 more sources

Multiplex PCR-Based Neutralization (MPBN) Assay for Titers Determination of the Three Types of Anti-Poliovirus Neutralizing-Antibodies

Vaccines, 2020
Determination of poliovirus-neutralizing antibodies is an important part of clinical studies of poliovirus vaccines, epidemiological surveillance and seroprevalence studies that are crucial for global polio eradication campaigns.
Hasmik Manukyan, Svetlana Petrovskaya, Konstantin Chumakov, Majid Laassri   +3 more
doaj   +1 more source

Poliovirus immunity among adults in the Democratic Republic of the Congo: a cross-sectional serosurvey

BMC Infectious Diseases, 2022
Background Vaccination efforts to eradicate polio currently focus on children under 5 years of age, among whom most cases of poliomyelitis still occur. However, in the Democratic Republic of the Congo (DRC), an outbreak of wild poliovirus type 1 occurred
Vivian H. Alfonso, Arie Voorman, Nicole A. Hoff, William C. Weldon, Sue Gerber, Adva Gadoth, Megan Halbrook, Amelia Goldsmith, Patrick Mukadi, Reena H. Doshi, Guillaume Ngoie-Mwamba, Trevon L. Fuller, Emile Okitolonda-Wemakoy, Jean-Jacques Muyembe-Tamfum, Anne W. Rimoin   +14 more
doaj   +1 more source

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

International Journal of Infectious Diseases, 2019
This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut.
Merav Weil, Galia Rahav, Raz Somech, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Victoria Indenbaum, Itay Bar Or, Ella Mendelson, Danit Sofer, Lester M. Shulman   +11 more
doaj   +1 more source

A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]

, 2017
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel, Delgui, Laura Ruth   +1 more
core   +2 more sources

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy [PDF]

, 2019
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different ...
Alonso, Corona, Arcos, María José, Bañas, Helena, Bergua, Juan M., Casas-Avilés, Ignacio, Durán, Esther, Hassouneh, Fakhri, López-Sejas, Nelson, Pera Rojas, Alejandra, Solana, Rafael, Sánchez-Correa, Beatriz, Tarazona, Raquel, Valhondo, Isabel   +12 more
core   +1 more source

Type 2 poliovirus detection after global withdrawal of trivalent oral vaccine

New England Journal of Medicine, 2018
BACKGROUND Mass campaigns with oral poliovirus vaccine (OPV) have brought the world close to the eradication of wild poliovirus. However, to complete eradication, OPV must itself be withdrawn to prevent outbreaks of vaccine‐derived poliovirus (VDPV ...
I. Blake, M. Pons-Salort, N. Molodecky, O. Diop, P. Chenoweth, A. Bandyopadhyay, M. Zaffran, R. Sutter, N. Grassly   +8 more
semanticscholar   +1 more source