Results 71 to 80 of about 308,092 (299)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

In Vitro Evaluation of the Permeability of Different Resorbable Xenogeneic Membranes after Collagenolytic Degradation

Membranes, 2022
In this in vitro study, we compare the penetration of cells through different resorbable collagen membranes, which were collagenolytically degraded over different time periods.
Ramona Kölliker, Stefan P. Hicklin, Constanze Hirsiger, Chun Ching Liu, Fredi Janett, Patrick R. Schmidlin   +5 more
doaj   +1 more source

Observation of Mixing-induced CP Violation in the Neutral B Meson System

, 2002
This report describes an observation of mixing-induced CP violation and a measurement of the CP violation parameter, sin(2phi_1), with the Belle detector at the KEKB asymmetric e+e- collider.
Abe, K., Abe, K., Abe, R., Abe, T., Adachi, I., Ahn, Byoung Sup, Aihara, H., Akatsu, M., Asano, Y., Aso, T., Aushev, T., Bakich, A. M., Ban, Y., Banas, E., Behari, S., Behera, P. K., Bondar, A., Bozek, A., Bračko, M., Browder, T. E., Casey, B. C., Chang, P., Chao, Y., Cheon, B. G., Chistov, R., Choi, S. -K., Choi, Y., Dong, L. Y., Dragic, J., Drutskoy, A., Eidelman, S., Eiges, V., Enari, Y., Everton, C. W., Fang, F., Fukunaga, C., Fukushima, M., Gabyshev, N., Garmash, A., Gershon, T., Golob, B., Gordon, A., Guler, H., Guo, R., Haba, J., Hamasaki, H., Hanagaki, K., Handa, F., Hara, K., Hara, T., Hastings, N. C., Hayashii, H., Hazumi, M., Heenan, E. M., Higuchi, I., Higuchi, T., Hojo, T., Hokuue, T., Hoshi, Y., Hou, S. R., Hou, W. -S., Hsu, S. -C., Huang, H. -C., Igaki, T., Iijima, T., Ikeda, H., Inami, K., Ishikawa, A., Ishino, H., Itoh, R., Iwasaki, H., Iwasaki, Y., Jackson, D. J., Jang, H. K., Kakuno, H., Kang, J. H., Kang, J. S., Kapusta, P., Katayama, N., Kawai, H., Kawai, H., Kawakami, Y., Kawamura, N., Kawasaki, T., Kichimi, H., Kim, D. W., Kim, H. J., Kim, H. O., Kim, Heejong, Kim, Hyunwoo, Kim, S. K., Kim, T. H., Kinoshita, K., Konishi, H., Korpar, S., Križan, P., Krokovny, P., Kulasiri, R., Kumar, S., Kuzmin, A., Kwon, Y. -J., Lange, J. S., Leder, G., Lee, S. H., Limosani, A., Liventsev, D., Lu, R. -S., MacNaughton, J., Majumder, G., Mandl, F., Marlow, D., Matsuishi, T., Matsumoto, S., Matsumoto, T., Mikami, Y., Mitaroff, W., Miyabayashi, K., Miyabayashi, Y., Miyake, H., Miyata, H., Moloney, G. R., Mori, S., Mori, T., Murakami, A., Nagamine, T., Nagasaka, Y., Nagashima, Y., Nakadaira, T., Nakano, E., Nakao, M., Nam, J. W., Natkaniec, Z., Neichi, K., Nishida, S., Nitoh, O., Noguchi, S., Nozaki, T., Ogawa, S., Ohshima, T., Okabe, T., Okuno, S., Olsen, S. L., Ostrowicz, W., Ozaki, H., Pakhlov, P., Palka, H., Park, C. S., Park, C. W., Park, H., Park, K. S., Peak, L. S., Perroud, J. -P., Peters, M., Piilonen, L. E., Prebys, E., Rodriguez, J. L., Ronga, F., Rozanska, M., Rybicki, K., Sagawa, H., Sakai, Y., Satapathy, M., Satpathy, A., Schneider, O., Schrenk, S., Schwanda, C., Semenov, S., Senyo, K., Sevior, M. E., Shibuya, H., Shwartz, B., Sidorov, V., Singh, J. B., Stanič, S., Sugi, A., Sugiyama, A., Sumisawa, K., Sumiyoshi, T., Suzuki, K., Suzuki, S., Suzuki, S. Y., Tajima, H., Takahashi, T., Takasaki, F., Takita, M., Tamai, K., Tamura, N., Tanaka, J., Tanaka, M., Taylor, G. N., Teramoto, Y., Tokuda, S., Tomoto, M., Tomura, T., Tovey, S. N., Trabelsi, K., Trischuk, W., Tsuboyama, T., Tsukamoto, T., Uehara, S., Ueno, K., Unno, Y., Uno, S., Ushiroda, Y., Vahsen, S. E., Varvell, K. E., Wang, C. C., Wang, C. H., Wang, J. G., Wang, M. -Z., Watanabe, Y., Won, E., Yabsley, B. D., Yamada, Y., Yamaga, M., Yamaguchi, A., Yamamoto, H., Yamanaka, T., Yamashita, Y., Yamauchi, M., Yashima, J., Yokoyama, M., Yuan, Y., Yusa, Y., Yuta, H., Zhang, C. C., Zhang, J., Zheng, Y., Zhilich, V., Žontar, D.   +229 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Torsional phacoemulsification: A pilot study to revise the "harm scale" evaluating the endothelial damage and the visual acuity after cataract surgery. [PDF]

PLoS ONE, 2017
To study the effect of torsional phacoemulsification energy on corneal endothelium evaluating the relationship between changes of endothelial cells and postoperative visual acuity.This prospective clinical observational cohort study included 50 patients ...
Francesco Saverio Sorrentino, Silvia Matteini, Aurelio Imburgia, Claudio Bonifazzi, Adolfo Sebastiani, Francesco Parmeggiani   +5 more
doaj   +1 more source

DaMaSCUS: The Impact of Underground Scatterings on Direct Detection of Light Dark Matter [PDF]

, 2017
Conventional dark matter direct detection experiments set stringent constraints on dark matter by looking for elastic scattering events between dark matter particles and nuclei in underground detectors.
Emken, Timon, Kouvaris, Chris
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Policy Gradient Algorithm to Alleviate the Multi-Agent Value Overestimation Problem in Complex Environments

Sensors, 2023
Multi-agent reinforcement learning excels at addressing group intelligent decision-making problems involving sequential decision-making. In particular, in complex, high-dimensional state and action spaces, it imposes higher demands on the reliability ...
Yang Yang, Jiang Li, Jinyong Hou, Ye Wang, Huadong Zhao   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

An eclipsing binary distance to the Large Magellanic Cloud accurate to 2 per cent

, 2013
In the era of precision cosmology it is essential to determine the Hubble Constant with an accuracy of 3% or better. Currently, its uncertainty is dominated by the uncertainty in the distance to the Large Magellanic Cloud (LMC) which as the second ...
A Kruszewski, A Udalski, A. Gallenne, A. Udalski, AG Riess, Alistair R. Walker, Andrew J. Monson, AZ Bonanos, B Paczyński, B. Pilecki, BE Schaefer, CH Lacy, D Graczyk, D Graczyk, D. Graczyk, D. Minniti, E Komatsu, EF Guinan, EL Fitzpatrick, F van Leeuwen, F. Bresolin, G Pietrzyński, G Pojmański, G. Bono, G. Pietrzyński, GF Benedict, GP Di Benedetto, I. B. Thompson, I. Soszyński, IB Thompson, J. Storm, JM Mazzarella, K. Suchomska, K. Ulaczyk, M. Górski, M. K. Szymański, M. Kubiak, MAT Groenewegen, N. Nardetto, P. G. Prada Moroni, P. Karczmarek, P. Konorski, P. Pietrukowicz, R. P. Kudritzki, R. Poleski, R. Smolec, RE Wilson, RP van der Marel, S. Kozłowski, S. Villanova, TE Lutz, W Van Hamme, W. Gieren, WL Freedman, WL Freedman, Ł. Wyrzykowski   +55 more
core   +1 more source