Results 81 to 90 of about 212,448 (296)

Recreating history: The evolving negotiation of staged authenticity in tourism experiences

, 2022
This study advances understanding of staged authenticity in historical heritage tourism experiences by investigating consumer views on a new tourism attraction that seeks to recreate an authentic European medieval culture experience in an inauthentic ...
Yang, ECL, Le, TH, Gardiner, S, Khoo, C, Vada, S   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Textured image segmentation using multiresolution Markov random fields and a two-component texture model [PDF]

In this paper we propose a multiresolution Markov Random Field (MMRF) model for segmenting textured images. The Multiresolution Fourier Transform (MFT) is used to provide a set of spatially localised texture descriptors, which are based on a two ...
Wilson, Roland, Li, Chang-Tsun
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Random Covariance Heterogeneity in Discrete Choice Models [PDF]

The area of discrete choice modelling has developed rapidly in recent years. In particular, continuing refinements of the Generalised Extreme Value (GEV) model family have permitted the representation of increasingly complex patterns of substitution and ...
Stephane Hess, John Polak, Denis Bolduc
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Model oczekiwanych strat kredytowych w sprawozdawczości finansowej: Koncepcja i zastosowanie

, 2021
Międzynarodowy Standard Sprawozdawczości Finansowej 9 „Instrumenty finansowe” wprowadził nowy model określania odpisów aktualizujących wartość aktywów oraz ujmowania rezerw na gwarancje finansowe i zobowiązania do udzielenia pożyczek, znany jako model ...
Frendzel, Maciej; Uniwersytet Łódzki, Wydział Zarządzania, Katedra Rachunkowości
core   +2 more sources

P-42 Sensitivity Analysis of [Ru(bpy)3] 2+/TPrA Based ECL Reaction Kinetics

, 2020
A series of DAEs (differential algebraic equations) was developed to model electrochemiluminescent (ECL) reactions. This model was specified for the Ru(bpy)32+ /TPrA reaction.
Navarro, Nicholas
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

An Alternating Current Electroosmotic Flow‐Based Ultrasensitive Electrochemiluminescence Microfluidic System for Ultrafast Monitoring, Detection of Proteins/miRNAs in Unprocessed Samples

Advanced Science
Early diagnosis of acute diseases is restricted by the sensitivity and complex process of sample treatment. Here, an ultrasensitive, rapid, and portable electrochemiluminescence‐microfluidic (ECL‐M) system is described via sandwich‐type immunoassay and ...
Huiwen Xiong, Chenxin Zhu, Changhao Dai, Xin Ye, Yuanyuan Li, Pintao Li, Shuang Yang, Ghazala Ashraf, Dacheng Wei, Hui Chen, Huali Shen, Jilie Kong, Xueen Fang   +12 more
doaj   +1 more source