Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions. [PDF]
NucleusSandria S, King MC.
europepmc +1 more source
Femtosecond‐Laser Mould Texturing Enables Tunable Biointerfaces in COC Microfluidics
Advanced Materials Interfaces, EarlyView.Femtosecond‐laser texturing of injection‐mould inserts enables scalable engineering of biointerfaces in cyclic olefin copolymer microfluidics. Replicated micro‐ and nano‐topographies modulate surface roughness and wettability, leading to texture‐dependent protein adsorption and cell adhesion without chemical post‐processing.
Irene Varela‐Leniz +9 more
wiley +1 more source
Deep phenotyping of an ATDC5 in-vitro cartilage model system. [PDF]
Bone RepKlawonn A +6 more
europepmc +1 more source
An Injectable Electroactive Hydrogel Engineered for Stable Bioelectronic Interfaces
Advanced Materials Interfaces, EarlyView.Injectable electroconductive hydrogels enable soft, conformal, and stable bioelectronic interfaces for electroceutical therapies. A catechol‐modified hyaluronic acid/alginate/edge‐functionalized graphene platform combines wet adhesion, shear‐thinning injectability, tissue‐matched mechanics, and electrochemical functionality.
Ying Zhou +11 more
wiley +1 more source
Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets
Advanced Materials Technologies, EarlyView.This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu +7 more
wiley +1 more source
Identification of Pancreatic Ductal Adenocarcinoma Extracellular Matrix Signatures from In-Depth Proteomic Profiling that Correlate with Lymphocyte Infiltration. [PDF]
Cancer Res CommunConsidine JM +8 more
europepmc +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus. [PDF]
Bioact MaterChoi M +4 more
europepmc +1 more source
Topography‐Regulated Screening Platform for Myoblast Contact Guidance
Advanced Materials Technologies, EarlyView.This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng +6 more
wiley +1 more source
The nucleus as a mechanobiological hub in muscle aging. [PDF]
NucleusEsen O, Battey E, Stroud MJ, Kirby TJ.
europepmc +1 more source