Results 61 to 70 of about 6,816 (172)

Comparison of several combinations maintenance and reliever therapy for asthma patients

open access: yesRevista Alergia México, 2018
Background: If asthma patients fail to achieve symptom control using a medium dose of inhaled corticosteroid (ICS) alone, addition of a long-acting β2 agonist (LABA) is the preferred treatment.
Pablo Andrés Miranda-Machado
doaj  

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle   +12 more
wiley   +1 more source

Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study

open access: yesClinical &Experimental Allergy, EarlyView.
Global Asthma Network Phase I surveyed children, adolescents, and adults worldwide to assess the prevalence of asthma, rhinoconjunctivitis, and eczema. Human Development Index (HDI) and Gini inequality index (GinI) were important explanatory factors for prevalence variability of these conditions, with hotspots in areas with high HDI and high GinI ...
Luis García‐Marcos   +15 more
wiley   +1 more source

Evaluación de la eficiencia de risedronato 75 mg frente a alendronato genérico 70 mg, en mujeres con osteoporosis postmenopáusica y fractura vertebral previa en España

open access: yesRevista de Osteoporosis y Metabolismo Mineral, 2011
Introducción: Las fracturas de cadera en mujeres con osteoporosis tienen gran impacto clínico y económico. El objetivo es estimar la relación coste-utilidad incremental (RCUI) de risedronato 75 mg 2 días consecutivos/mes vs.
Oyágüez Martín I   +5 more
doaj  

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

open access: yes
Allergy, EarlyView.
Jaime Bernaola   +14 more
wiley   +1 more source

Association of Post‐Oral Glucose Tolerance Test Hypoglycaemia With Clinical Features, Incident Diabetes and Mortality in the Di@bet.es Cohort

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate the association of post‐oral glucose tolerance test (OGTT) hypoglycaemia with clinical features, incident diabetes and mortality. Materials and Methods This population‐based cohort study included 2924 adults (median age 49 years, 1680 women) without known diabetes who underwent a 75‐g OGTT as part of the Di@bet.es Study ...
Tomás González‐Vidal   +14 more
wiley   +1 more source

Análisis de costo utilidad del uso de suturas recubiertas con triclosán para prevenir la infección de sitio quirúrgico en Colombia

open access: yesInfectio
Objetivo: Determinar la costo utilidad del uso de suturas recubiertas de triclosán desde la perspectiva del sistema de salud colombiano.Material y métodos: Se desarrolló un árbol de decisión que incluía los costos, la efectividad y la calidad de vida de ...
Paula Andrea Castro-García
doaj   +1 more source

Reflection on the current cuban economic, politic and its impact on the System of Health

open access: yesActa Médica del Centro, 2014
The method of logical reasoning that Commander Fidel uses in his reflections is a worthy model of incorporating because it constitutes a very useful tool for the political-ideological preparation and the reinforcement of values.
Silvio Antonio Gómez González
doaj  

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio   +38 more
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

open access: yesThe FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova   +12 more
wiley   +1 more source

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