Results 81 to 90 of about 6,860 (176)
ABSTRACT Drug hypersensitivity reactions (DHRs) are a global health concern and remain challenging to investigate owing to the heterogeneity of endotypes and phenotypes, as well as the lack of standardized biomarkers. Until recently, strict drug avoidance was the only management strategy for severe DHRs.
Ana Maria Copaescu +13 more
wiley +1 more source
PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory +13 more
wiley +1 more source
Una mirada a la economía de la salud
La salud no tiene precio, aunque para recuperarla o mantenerla sea preciso incurrir en elevados costos. Por tanto, la economía y la salud deben constituir un binomio inseparable.
Ramón Sergio George Quintero +3 more
doaj
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez +10 more
wiley +1 more source
Antecedentes. Se realizó una revisión bibliográfica y análisis bibliométrico de estudios que han intentado determinar la asociación entre exposición al humo de biomasa (madera, carbón vegetal, estiércol, residuos de la agricultura) como factor de riesgo ...
Nelson Alvis Guzmán +1 more
doaj
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis
Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu +7 more
wiley +1 more source
Terminologías económicas necesarias para incrementar la eficiencia y la calidad en salud.
Eficiencia y calidad son conceptos polémicos y debatidos con la inclusión de la normalización y metrología como complemento para lograr la eficacia de los procesos.
Damaris Sierra Díaz +2 more
doaj +2 more sources
Aspectos teóricos sobre la salud como un determinante del crecimiento económico
Las nuevas teorías del crecimiento económico y los desarrollos en la economía de la salud han planteado, de forma paralela, una relación recíproca entre la salud y el crecimiento.
Juan Miguel Gallego
doaj
Light switches gene delivery: Optomechanical actuation of multilamellar pDNA nanocomplexes formulated with single‐component azobenzene‐scaffolded ionizable Janus dendrimers (Azo‐IAJDs) enhances light‐regulated transfection in vitri and in vivo. The initial E or Z state programs cell selectivity and passive organ targeting without added ligands ...
María J. Puerto‐Madorrán +10 more
wiley +1 more source
ABSTRACT Objectives First, to evaluate whether the ratio of soluble fms‐like tyrosine kinase‐1 to placental growth factor (sFlt‐1/PlGF) is associated with hemodynamic changes in ophthalmic artery (OA) Doppler in near‐term pregnancy. Second, to assess the performance of OA Doppler to rule in and rule out angiogenic factor imbalance.
M. F. Tinajero +7 more
wiley +1 more source

