Results 61 to 70 of about 49,480 (260)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A happy place to be in: how beliefs about living places influence depression in Chinese international student returnees

BMC Public Health
Background The mental health of Chinese international student returnees is a critical concern impacting their well-being and successful reintegration into home society, especially in the post-COVID-19 era.
Ruining Jin, Meiling Yin, Qiang Shen, Tam-Tri Le   +3 more
doaj   +1 more source

Decoupling effect of carbon emissions in the Yangtze River Delta region based on GDIM factor decomposition

Frontiers in Environmental Science
IntroductionQuantifying carbon emissions and identifying their drivers are essential for formulating effective climate policies in key economic zones. This study analyzes the decoupling effects and driving factors of carbon emissions in China’s Yangtze ...
Wan Youwei, Pan Binhui, Xu Yaru, Yu Yan, Yang Jiajia, Tang Xinfa   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Le défi de l’Organisation pour l’harmonisation en Afrique du droit des affaires face au développement des marchés financiers africains : Quid de la protection des investisseurs

Recht in Afrika, 2020
By the time the founding fathers of the Organization for the Harmonization of Business Law in Africa (OHADA) signed the Treaty of Port Louis, the financial markets in Western and Central Africa were embryonic.
Gloria Lubaki Sita
doaj   +1 more source

A Law and Economics Approach to Norms in Transnational Commercial Transactions: Incorporation and Internalisation [PDF]

Erasmus Law Review, 2016
A Law and Economics Approach to Norms in Transnational Commercial Transactions: Incorporation and Internalisation In today’s global economy, a noticeable trend is that the traditional state-law-centred legal framework is increasingly challenged by self-regulatory private orders. Commercial norms, commercial arbitration and social sanctions at
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Legal and Economic Conditions for Running a Care Farm: A Polish Case Study

Agriculture
The purpose of this paper is to present the situation of Polish care farms in the context of legal and economic conditions. The need to analyze this topic arises from the current lack of literature that has synthetically addressed the challenges posed by
Monika Małgorzata Wojcieszak-Zbierska, Agnieszka Wojcieszak-John   +1 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

POST-WAR ECONOMIC AND DEMOGRAPHIC RECOVERY OF UKRAINE IN THE CONTEXT OF EUROPEAN INTEGRATION: CURRENT TRENDS AND FUTURE PROSPECTS

Baltic Journal of Economic Studies
The Russian Federation's armed aggression has had a negative impact on the development of the Ukrainian economy. Today, the economy requires a comprehensive reboot and renewal, particularly given Ukraine's move towards EU membership.
Yana Pavko, Maksim Lyskov, Kateryna Kropyvna   +2 more
doaj   +1 more source