Results 31 to 40 of about 61,370 (255)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Assessment framework to assist ecosystem-based adaptation implementation at local level: evidence from Spain and Portugal

Global Sustainability
Technical Summary Climate hazard events, such as floods and heatwaves, are becoming more frequent and severe. This paper focuses on coastal urban areas and addresses the need for implementing effective ecosystem-based adaptation (EbA) measures.
Mar Riera-Spiegelhalder, Adrián Ferrandis Martínez, Luís Campos Rodrigues   +2 more
doaj   +1 more source

Can Payments for Ecosystem Services Contribute to Adaptation to Climate Change? Insights from a Watershed in Kenya

Ecology and Society, 2014
Climate change presents new challenges for the management of social-ecological systems and the ecosystem services they provide. Although the instrument of payments for ecosystem services (PES) has emerged as a promising tool to safeguard or enhance the ...
Isabel van de Sand, John K. Mwangi, Sara Namirembe   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Assessing climate change-induced losses and damages to coastal ecosystem services: Empirical evidence from Manpura Island, Bangladesh

Climate Risk Management
Under the on-going climate change, slow-onset events, such as sea-level rise and salinity intrusion, have a more pronounced effect on biodiversity and ecosystem services, which have fewer options for adaptation compared to human systems, resulting in ...
Joy Bhowmik, Haseeb Md. Irfanullah, Samiya Ahmed Selim, Mohammad Budrudzaman   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Understanding stakeholder preferences for flood adaptation alternatives with natural capital implications

Ecology and Society, 2016
Inland flood risks are defined by a range of environmental and social factors, including land use and floodplain management. Shifting patterns of storm intensity and precipitation, attributed to climate change, are exacerbating flood risk in regions ...
Jonathon R. Loos, Shannon H. Rogers
doaj   +1 more source

Rediscovering South Africa: Flood disaster risk management through ecosystem-based adaptation

Environmental and Sustainability Indicators, 2022
The emergence of ecosystem-based adaptation (EbA) has created a shift from the conventional adaptation approaches often accompanied by high costs, including conflicting interests associated with the dense urban fabric and inflexibility.
Emmanuel Tolulope Busayo, Ahmed Mukalazi Kalumba, Gbenga Abayomi Afuye, Adeyemi Oludapo Olusola, Olusola Oluwayemisi Ololade, Israel Ropo Orimoloye   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source