Results 181 to 190 of about 708,071 (281)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Species abundances surpass richness effects in the biodiversity-ecosystem function relationship across marine fishes. [PDF]

Nat Commun
Yan HF, Morais RA, Bellwood DR.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Editorial: Revisiting the Biome Concept With A Functional Lens

Frontiers in Ecology and Evolution, 2019
Daniel M. Griffith, Christopher J. Still, Colin P. Osborne   +2 more
doaj   +1 more source

Cascading Effects of Plant Hormone-induced Trait Shifts in Alnus rubra on Aquatic and Terrestrial Ecosystem Function. [PDF]

J Chem Ecol
Broe TY, Fabiani A, Kuijpers MCM, Jackrel SL.   +3 more
europepmc   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Nutrient connectivity via seabirds enhances dynamic measures of coral reef ecosystem function. [PDF]

PLoS Biol
Benkwitt CE, Zora A, Ebrahim A, Govinden R, Lange ID, Evans S, Schulze M, Cotton E, Bennett L, Graham NAJ.   +9 more
europepmc   +1 more source

Publisher Correction: Consistent effects of pesticides on community structure and ecosystem function in freshwater systems. [PDF]

Nat Commun, 2021
Rumschlag SL, Mahon MB, Hoverman JT, Raffel TR, Carrick HJ, Hudson PJ, Rohr JR.   +6 more
europepmc   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

The Bug-Network (BugNet): A Global Experimental Network Testing the Effects of Invertebrate Herbivores and Fungal Pathogens on Plant Communities and Ecosystem Function in Open Ecosystems. [PDF]

Ecol Evol
Kempel A, Adamidis GC, Anadón JD, Atkinson J, Auge H, Avtzis D, Bachelot B, Bashirzadeh M, Bota JL, Classen A, Constantinou I, Crawley M, de Bellis T, Dostal P, Ebeling A, Eisenhauer N, Eldridge DJ, Encina G, Estrada C, Everingham S, Fanin N, Feng Y, Gaspar M, Gooriah L, Graff P, Montalván EG, Montalván PG, Hartke TR, Huang L, Jochum M, Kaljund K, Karmiris I, Koorem K, Korell L, Laine AL, le Provost G, Lessard JP, Liu M, Liu X, Liu Y, Llancabure J, Loïez S, Loydi A, Marrero H, Gockel S, Montoya A, Münzbergová Z, Niu Y, Ott D, Oyarzabal M, Panitsa M, Papatheodorou E, Piper FI, Püssa K, Rand K, Saiz H, Sanders NJ, Schädler M, Scherber C, Semchenko M, Sepp SK, Shah MA, Shaheen I, Stein C, Stewart J, Tang Z, Tschan G, van Nouhuys S, Vandegehuchte ML, Vernon M, V R S, Wang J, Xiao Y, Xystrakis F, Yang J, Yang S, Zografou K, Allan E.   +77 more
europepmc   +1 more source