Results 101 to 110 of about 199,968 (239)
TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF
Cancer Science, EarlyView.Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan +9 more
wiley +1 more source
Cancer Science, EarlyView.Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai +10 more
wiley +1 more source
Cancer Science, EarlyView.Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao +8 more
wiley +1 more source
Liver Organoids: From Disease Modelling to Regenerative Medicine
Cell Proliferation, EarlyView.Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang +5 more
wiley +1 more source
Pancreatic β‐cell mitogenic regeneration in type 1 diabetes: A preclinical review
Diabetic Medicine, EarlyView.Abstract Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin‐producing pancreatic β‐cells, resulting in hyperglycaemia. The first‐line treatment for symptomatic T1D is exogenous insulin replacement to maintain glycaemic control.
James Cantley +3 more
wiley +1 more source
Ectopic pregnancy in simultaneous pancreas-kidney transplantation : A case report
, 2016 INTRODUCTION: We present a case report of ectopic pregnancy (EP) after simultaneous pancreas-kidney transplantation (SKPTx). PRESENTATION OF CASE: A 33-year-old female status post SKPTx suddenly got abdominal pain in the lower level.
Yamamoto, Shinji +3 more
core +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
Laparoscopic treatment of heterotopic pancreas in the prepyloric region
Journal of Minimal Access Surgery, 2006 Heterotopic pancreas is a rare condition and its diagnosis is often difficult. Traditionally the condition is treated by open surgery. We report two young women with symptomatic heterotopic pancreas located in the prepyloric region. In the first patient,
Galvez-Valdovinos R +4 more
doaj
, 2019 Joanna Pieńkowska,1 Beata Brzeska,1–3 Mariusz Kaszubowski,4 Oliwia Kozak,5 Anna Jankowska,6 Edyta Szurowska11II Department of Radiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland; 2Department of Biology and ...
Brzeska B +5 more
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Clinical-endoscopic ahd morphological characteristics of ectopic in wall of stomach pancreas in children [PDF]
, 2012 The result of clinical-morphological examination and treatment of 188 children with ectopic in wall of stomach pancreas is showed. The endoscopic criteria of diagnostics are presented.
Винокурова, Н. В. +9 more
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