Results 41 to 50 of about 456,952 (309)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Anomalous Spin‐Optical Helical Effect in Ti‐Based Kagome Metal

Advanced Materials, EarlyView.
The kagome lattice hosts diverse correlated quantum states, including elusive loop currents. We report spin‐handedness selective signals in CsTi3Bi5, termed the anomalous spin‐optical helical effect, surpassing conventional spin responses. Arising from light helicity coupled to spin‐orbital correlations, this effect provides a sensitive, indirect probe
Federico Mazzola, Wojciech Brzezicki, Chiara Bigi, Armando Consiglio, Luciano Jacopo D'Onofrio, Maria Teresa Mercaldo, Adam Kłosiński, François Bertran, Patrick Le Fèvre, Oliver J. Clark, Mark T. Edmonds, Manuel Tuniz, Alessandro De Vita, Vincent Polewczyk, Jeppe B. Jacobsen, Henrik Jacobsen, Jill A. Miwa, Justin W. Wells, Anupam Jana, Ivana Vobornik, Jun Fujii, Niccolo Mignani, Narges Tarakameh Samani, Alberto Crepaldi, Giorgio Sangiovanni, Anshu Kataria, Tommaso Morresi, Samuele Sanna, Pietro Bonfá, Brenden R. Ortiz, Ganesh Pokharel, Stephen D. Wilson, Domenico Di Sante, Carmine Ortix, Mario Cuoco   +34 more
wiley   +1 more source

Charge Transfer States in Donor–Acceptor Bulk‐Heterojunctions as Triplet–Triplet Annihilation Sensitizer for Solid‐State Photon Upconversion

Advanced Materials Interfaces, EarlyView.
A near‐infrared photosensitizer that facilitates efficient solid‐state photon upconversion by recycling triplets formed within a fullerene‐based donor–acceptor bulk‐heterojunction system is demonstrated. Spectroscopic investigations reveal that the energy of photogenerated charge transfer states of triplet character (3CT) is subsequently transferred to
Maciej Klein, Alexander R. Ireland, Evan G. Moore, Dennis Delic, Ajay K. Pandey   +4 more
wiley   +1 more source

Anabolic Steroid use in Sports and in Physical Activity: Overview and Analysis [PDF]

Sport Mont, 2018
Anabolic steroids,commonly referred to as anabolic androgenic steroids (AAS), are a family of hormones that comprises testosterone. Exposure to these substances can result in damage to human health, such as liver cancer, and to the environment.
Filomena Mazzeo
doaj   +1 more source

High throughput screening system for engineered cardiac tissues

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Three dimensional engineered cardiac tissues (3D ECTs) have become indispensable as in vitro models to assess drug cardiotoxicity, a leading cause of failure in pharmaceutical development.
Marshall S. Ma, Marshall S. Ma, Subramanian Sundaram, Lihua Lou, Arvind Agarwal, Christopher S. Chen, Thomas G. Bifano, Thomas G. Bifano   +7 more
doaj   +1 more source

The effects of entrepreneurship education [PDF]

, 2009
Entrepreneurship education ranks high on policy agendas in Europe and the US, but little research is available to assess its impact. To help close this gap we investigate whether entrepreneurship education a?ects intentions to be entrepreneurial ...
Acs, Ajzen, Ajzen, Alberti, Anna, Audretsch, Bagozzi, Bartus, Bird, Block, Caliendo, Cameron, Charness, Charness, Chen, Chrisman, Cunha, Cunha, Dainow, De Meza, De Meza, De Noble, Dietmar Harhoff, Dietrich, Donckels, Fayolle, Fayolle, Fiet, Georg von Graevenitz, Gibb Dyer, Gorman, Gundry, Harhoff, Kantor, Katz, Kim, Kolvereid, Kolvereid, Kolvereid, Krueger, Krueger, Kuratko, Lent, Lińán, Matthews, McMullan, Oosterbeek, Peterman, Rabin, Reynolds, Richard Weber, Robinson, Shane, Shane, Sheshinski, Souitaris, Sternberg, Tkachev, van Stel, Vesper, Wong   +60 more
core   +7 more sources

Degradation Mechanisms in PEM Water Electrolysis: Diagnosis and Impact

Advanced Materials Technologies, EarlyView.
This review provides an analysis of degradation mechanisms in proton electrolyte membrane water electrolyzers (PEMWE), focusing on all key components. It discusses diagnostic and measurement techniques for evaluating degradation, less‐studied mechanisms, and an expert survey.
Annik Bernhardt, Katja Lange, Robert Göckeritz, Erik Grunwald, Angelika Hähnel, Alexander Müller, Volker Naumann, Sistan Rasuli, Wolfram Münchgesang, Bruno G. Pollet, Kerstin Witte‐Bodnar, Klemens Ilse   +11 more
wiley   +1 more source

Functional and Structural Network Disorganizations in Typical Epilepsy With Centro-Temporal Spikes and Impact on Cognitive Neurodevelopment

Frontiers in Neurology, 2019
Epilepsy with Centrotemporal Spikes (ECTS) is the most common form of self-limited focal epilepsy. The pathophysiological mechanisms by which ECTS induces neuropsychological impairment in 15–30% of affected children remain unclear.
Emilie Bourel-Ponchel, Emilie Bourel-Ponchel, Mahdi Mahmoudzadeh, Mahdi Mahmoudzadeh, Azeez Adebimpe, Fabrice Wallois, Fabrice Wallois   +6 more
doaj   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source