Results 41 to 50 of about 450,363 (310)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji   +7 more
wiley   +1 more source

The effects of entrepreneurship education [PDF]

open access: yes, 2009
Entrepreneurship education ranks high on policy agendas in Europe and the US, but little research is available to assess its impact. To help close this gap we investigate whether entrepreneurship education a?ects intentions to be entrepreneurial ...
Acs   +60 more
core   +7 more sources

Charge Transfer States in Donor–Acceptor Bulk‐Heterojunctions as Triplet–Triplet Annihilation Sensitizer for Solid‐State Photon Upconversion

open access: yesAdvanced Materials Interfaces, EarlyView.
A near‐infrared photosensitizer that facilitates efficient solid‐state photon upconversion by recycling triplets formed within a fullerene‐based donor–acceptor bulk‐heterojunction system is demonstrated. Spectroscopic investigations reveal that the energy of photogenerated charge transfer states of triplet character (3CT) is subsequently transferred to
Maciej Klein   +4 more
wiley   +1 more source

Competitive E?ects of Vertical Integration with Downstream Oligopsony and Oligopoly [PDF]

open access: yes, 2009
We analyze the competitive e?ects of backward vertical integration by a partially vertically integrated ?rm that competes with non-integrated ?rms both upstream and downstream.
Loertscher, Simon, Reisinger, Markus
core   +4 more sources

Anabolic Steroid use in Sports and in Physical Activity: Overview and Analysis [PDF]

open access: yesSport Mont, 2018
Anabolic steroids,commonly referred to as anabolic androgenic steroids (AAS), are a family of hormones that comprises testosterone. Exposure to these substances can result in damage to human health, such as liver cancer, and to the environment.
Filomena Mazzeo
doaj   +1 more source

High throughput screening system for engineered cardiac tissues

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Introduction: Three dimensional engineered cardiac tissues (3D ECTs) have become indispensable as in vitro models to assess drug cardiotoxicity, a leading cause of failure in pharmaceutical development.
Marshall S. Ma   +7 more
doaj   +1 more source

A Dual Characterization of Incentive Efficiency [PDF]

open access: yes, 2001
We show that incentive e cient allocations in economies with adverse se- lection and moral hazard can be determined as optimal solutions to a linear programming problem and we use duality theory to obtain a complete charac- terization of the optima.
Jerez, Belén
core   +1 more source

Amyloid-beta peptide, oxidative stress and inflammation in Alzheimer’s disease: Potential neuroprotective effects of omega-3 polyunsaturated fatty acids [PDF]

open access: yes, 2010
Alzheimer’s disease is the most common form of dementia in the elderly and is a progressive neurodegenerative disorder characterised by a decline in cognitive function and also profound alterations in mood and behaviour. The pathology of the disease is
Dyall, Simon
core   +3 more sources

Enhancing Triplet Excitons Lifetime Through Controlled Intermolecular Interactions

open access: yesAdvanced Optical Materials, EarlyView.
Singlet fission (SF) is investigated in pentacene embedded in a surface‐anchored metal–organic framework, enabling a molecular arrangement inaccessible in pure organic crystals. This architecture changes the singlet fission dynamics significantly and enhances the triplet lifetime by almost four orders of magnitude.
Martin Richter   +9 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

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