Results 1 to 10 of about 43,604 (106)

Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue [PDF]

Cell Reports
Summary: Resident cardiac macrophages are critical mediators of cardiac function. Despite their known importance to cardiac electrophysiology and tissue maintenance, there are currently no stem-cell-derived models of human engineered cardiac tissues ...
Roberta I. Lock, Pamela L. Graney, Daniel Naveed Tavakol, Trevor R. Nash, Youngbin Kim, Eloy Sanchez, Jr., Margaretha Morsink, Derek Ning, Connie Chen, Sharon Fleischer, Ilaria Baldassarri, Gordana Vunjak-Novakovic   +11 more
doaj   +4 more sources

Integrating Macrophages into Human-Engineered Cardiac Tissue [PDF]

Cells
Heart disease remains a leading cause of morbidity and mortality worldwide, necessitating the development of in vivo models for therapeutic development.
Yi Peng Zhao, Barry M. Fine
doaj   +2 more sources

3094 Production of Engineered Cardiac Tissue for Disease Modeling [PDF]

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Cardiovascular diseases (CVD) is the leading cause of death worldwide in both men and women due to lack of cardiac regeneration after disease or damaged is caused.
Morgan Ellis, Elizabeth Lipke
doaj   +2 more sources

Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening [PDF]

Computer Methods and Programs in Biomedicine Update, 2023
Background:: The field of tissue engineering has provided valuable three-dimensional species-specific models of the human myocardium in the form of human Engineered Cardiac Tissues (hECTs) and similar constructs.
Jack F. Murphy, Kevin D. Costa, Irene C. Turnbull   +2 more
doaj   +2 more sources

Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype

Journal of Tissue Engineering, 2012
Quantifying structural features of native myocardium in engineered tissue is essential for creating functional tissue that can serve as a surrogate for in vitro testing or the eventual replacement of diseased or injured myocardium.
Richard A Lasher, Aric Q Pahnke, Jeffrey M Johnson, Frank B Sachse, Robert W Hitchcock   +4 more
doaj   +2 more sources

Maturation is required to model ischemia-reperfusion injury in engineered human cardiac tissues [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionMyocardial infarction remains a leading cause of mortality worldwide, with reperfusion therapy as the clinical standard of care. However, its efficacy is limited by the paradoxical injury caused by ischemia-reperfusion (I/R).MethodsMicro ...
Trevor R. Nash, Roberta I. Lock, Vanessa Yi Ran Li, Morgan J. Lamberti, Youngbin Kim, Eloy Sanchez, Sharon Fleischer, Daniel Naveed Tavakol, Gordana Vunjak-Novakovic, Gordana Vunjak-Novakovic, Gordana Vunjak-Novakovic   +10 more
doaj   +2 more sources

Human Induced Pluripotent Stem Cell Encapsulation Geometry Impacts Three-Dimensional Developing Human Engineered Cardiac Tissue Functionality. [PDF]

Tissue Eng Part A, 2022
Ellis ME, Harris BN, Hashemi M, Harvell BJ, Bush MZ, Hicks EE, Finklea FB, Wang EM, Nataraj R, Young NP, Turnbull IC, Lipke EA.   +11 more
europepmc   +2 more sources

Membrane Remodeling of Human-Engineered Cardiac Tissue by Chronic Electric Stimulation. [PDF]

ACS Biomater Sci Eng, 2023
Sesena-Rubfiaro A, Prajapati NJ, Paolino L, Lou L, Cotayo D, Pandey P, Shaver M, Hutcheson JD, Agarwal A, He J.   +9 more
europepmc   +2 more sources

Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology.

Am J Physiol Heart Circ Physiol, 2021
de Lange WJ, Farrell ET, Kreitzer CR, Jacobs DR, Lang D, Glukhov AV, Ralphe JC.   +6 more
europepmc   +2 more sources

Editorial: Bioengineering and biotechnology approaches in cardiovascular sciences, volume III [PDF]

Frontiers in Bioengineering and Biotechnology
Thanh Nguyen, Issei Komuro, Issei Komuro, Jianyi Zhang, Jianyi Zhang   +4 more
doaj   +2 more sources