Results 31 to 40 of about 2,612,478 (275)

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Scientific Reports, 2021
The extracellular matrix (ECM) of engineered human cardiac tissues corresponds to simplistic biomaterials that allow tissue assembly, or animal derived off-the-shelf non-cardiac specific matrices.
Miguel F. Tenreiro, Henrique V. Almeida, Tomás Calmeiro, Elvira Fortunato, Lino Ferreira, Paula M. Alves, Margarida Serra   +6 more
doaj   +1 more source

Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium

Stem Cells International, 2020
Cardiac tissue engineering using hiPSC-derived cardiomyocytes is a promising avenue for cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation, and disease modeling.
Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, Kareen L. K. Coulombe   +3 more
doaj   +1 more source

Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves [PDF]

, 2008
We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph.
Schaefermeier, P. K., Meiser, B. M., Reichart, B., Sodian, R., Szymanski, D., Fu, P., Weiss, F., Lueth, T., Schmitz, C., B. Reichart, D. Szymanski, B.M. Meiser, R. Sodian, P.K. Schaefermeier, F. Weiss, T. Lueth, P. Fu, C. Schmitz, Schaefermeier, P. K.;Szymanski, D.;Weiss, F.;Fu, P.;Lueth, T.;Schmitz, C.;Meiser, B. M.;Reichart, B.;Sodian, R.   +18 more
core   +1 more source

Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft

Inflammation and Regeneration, 2018
Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injured hearts as an engineered tissue aiming for ...
Hidetoshi Masumoto, Jun K. Yamashita
doaj   +1 more source

Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling

Advanced NanoBiomed Research, 2021
Heart disease is one of the leading causes of death in the world. There is a growing demand for in vitro cardiac models that can recapitulate the complex physiology of the cardiac tissue.
Andrew House, Iren Atalla, Eun Jung Lee, Murat Guvendiren   +3 more
doaj   +1 more source

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. [PDF]

Stem Cell Reports, 2017
Lee EK, Tran DD, Keung W, Chan P, Wong G, Chan CW, Costa KD, Li RA, Khine M.   +8 more
europepmc   +2 more sources

Cardiac tissue engineering

Journal of the Serbian Chemical Society, 2005
We hypothesized that clinically sized (1-5 mm thick),compact cardiac constructs containing physiologically high density of viable cells (?108 cells/cm3) can be engineered in vitro by using biomimetic culture systems capable of providing oxygen transport and electrical stimulation, designed to mimic those in native heart.
Milica Radisic, Gordana Vunjak-Novakovic
openaire   +4 more sources

Mechanostimulation Protocols for Cardiac Tissue Engineering [PDF]

BioMed Research International, 2013
Owing to the inability of self-replacement by a damaged myocardium, alternative strategies to heart transplantation have been explored within the last decades and cardiac tissue engineering/regenerative medicine is among the present challenges in biomedical research.
GOVONI, MARCO, MUSCARI, CLAUDIO, GUARNIERI, CARLO, GIORDANO, EMANUELE DOMENICO   +3 more
openaire   +3 more sources

Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues

Journal of Tissue Engineering, 2019
The immaturity of human induced pluripotent stem cell derived engineered cardiac tissues limits their ability to regenerate damaged myocardium and to serve as robust in vitro models for human disease and drug toxicity studies.
Marc Dwenger, William J Kowalski, Fei Ye, Fangping Yuan, Joseph P Tinney, Shuji Setozaki, Takeichiro Nakane, Hidetoshi Masumoto, Peter Campbell, William Guido, Bradley B Keller   +10 more
doaj   +1 more source

IGF1 and NRG1 Enhance Proliferation, Metabolic Maturity, and the Force-Frequency Response in hESC-Derived Engineered Cardiac Tissues

Stem Cells International, 2017
Insulin-like growth factor 1 (IGF1) and neuregulin-1β (NRG1) play important roles during cardiac development both individually and synergistically. In this study, we analyze how 3D cardiac tissue engineered from human embryonic stem cell- (hESC-) derived
Cassady E. Rupert, Kareen L. K. Coulombe
doaj   +1 more source