Results 41 to 50 of about 2,612,478 (275)

Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we performed and compared single‐cell transcriptomic ...
Yin‐Yu Lam, Wendy Keung, Chun‐Ho Chan, Lin Geng, Nicodemus Wong, David Brenière‐Letuffe, Ronald A. Li, Yiu‐Fai Cheung   +7 more
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Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure

Stem Cells International, 2021
Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are under preclinical investigation as a cell-based therapy for heart failure post-myocardial infarction.
Ikeotunye Royal Chinyere, Pierce Bradley, Joshua Uhlorn, Joshua Eason, Saffie Mohran, Giuliana G. Repetti, Sherry Daugherty, Jen Watson Koevary, Steven Goldman, Jordan J. Lancaster   +9 more
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Head-to-head comparison of two engineered cardiac grafts for myocardial repair: From scaffold characterization to pre-clinical testing

Scientific Reports, 2018
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge.
Isaac Perea-Gil, Carolina Gálvez-Montón, Cristina Prat-Vidal, Ignasi Jorba, Cristina Segú-Vergés, Santiago Roura, Carolina Soler-Botija, Oriol Iborra-Egea, Elena Revuelta-López, Marco A. Fernández, Ramon Farré, Daniel Navajas, Antoni Bayes-Genis   +12 more
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Recent Advances on Electroconductive Hydrogels Used in Heart Repair and Regeneration

Advances in Materials Science and Engineering, 2022
Myocardial infarction (MI) permanently damages cardiac tissue. Tissue engineering exhibits tremendous potential as a strategy for developing engineered tissue to repair congenital abnormalities in the heart and/or cardiovascular tissue. Electroconductive
Xu Yan, Huan Sun, Ping Yang
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Traction force microscopy of engineered cardiac tissues. [PDF]

PLoS ONE, 2018
Cardiac tissue development and pathology have been shown to depend sensitively on microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo and in vitro systems.
Francesco Silvio Pasqualini, Ashutosh Agarwal, Blakely Bussie O'Connor, Qihan Liu, Sean P Sheehy, Kevin Kit Parker   +5 more
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Cardiac Tissue Engineering for the Treatment of Myocardial Infarction

Journal of Cardiovascular Development and Disease, 2021
Poor cell engraftment rate is one of the primary factors limiting the effectiveness of cell transfer therapy for cardiac repair. Recent studies have shown that the combination of cell-based therapy and tissue engineering technology can improve stem cell ...
Dongmin Yu, Xiaowei Wang, Lei Ye
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Electrospun Acellular Heart ECM for Cardiac Tissue Engineering [PDF]

Iranian Journal of Chemical Engineering, 2021
Electrospun nanofiber is one of the promising alternatives for use in tissue engineering and drug delivery due to its controllable characteristics. However, choosing an appropriate biomaterial for a specific tissue regeneration plays a significant role ...
Sh. mashayekhiyan, M. Jahanshahi, M. Jafarkhani, K. Entezari, M. Niazi, H. Kabir   +5 more
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Bioreactor Platform for Biomimetic Culture and in situ Monitoring of the Mechanical Response of in vitro Engineered Models of Cardiac Tissue

Frontiers in Bioengineering and Biotechnology, 2020
In the past two decades, relevant advances have been made in the generation of engineered cardiac constructs to be used as functional in vitro models for cardiac research or drug testing, and with the ultimate but still challenging goal of repairing the ...
Diana Massai, Diana Massai, Giuseppe Pisani, Giuseppe Pisani, Giuseppe Pisani, Giuseppe Isu, Giuseppe Isu, Giuseppe Isu, Andres Rodriguez Ruiz, Giulia Cerino, Giulia Cerino, Renato Galluzzi, Alessia Pisanu, Alessia Pisanu, Andrea Tonoli, Cristina Bignardi, Cristina Bignardi, Alberto L. Audenino, Alberto L. Audenino, Anna Marsano, Anna Marsano, Umberto Morbiducci, Umberto Morbiducci   +22 more
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Towards a Tissue-Engineered Contractile Fontan-Conduit: The Fate of Cardiac Myocytes in the Subpulmonary Circulation. [PDF]

PLoS ONE, 2016
The long-term outcome of patients with single ventricles improved over time, but remains poor compared to other congenital heart lesions with biventricular circulation.
Daniel Biermann, Alexandra Eder, Florian Arndt, Hatim Seoudy, Hermann Reichenspurner, Thomas Mir, Arlindo Riso, Rainer Kozlik-Feldmann, Kersten Peldschus, Michael G Kaul, Tillman Schuler, Susanne Krasemann, Arne Hansen, Thomas Eschenhagen, Jörg S Sachweh   +14 more
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Engineered Macroscale Cardiac Constructs Elicit Human Myocardial Tissue-like Functionality

Stem Cell Reports, 2019
Summary: In vitro surrogate models of human cardiac tissue hold great promise in disease modeling, cardiotoxicity testing, and future applications in regenerative medicine.
Maria Valls-Margarit, Olalla Iglesias-García, Claudia Di Guglielmo, Leonardo Sarlabous, Karine Tadevosyan, Roberto Paoli, Jordi Comelles, Dolores Blanco-Almazán, Senda Jiménez-Delgado, Oscar Castillo-Fernández, Josep Samitier, Raimon Jané, Elena Martínez, Ángel Raya   +13 more
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