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International Journal of Pharmaceutics, 2009
We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were added to HR skin homogenate SF, and incubated at 37 degrees C ...
Toshiaki, Sato +2 more
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We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were added to HR skin homogenate SF, and incubated at 37 degrees C ...
Toshiaki, Sato +2 more
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Edaravone Part 2: Antibacterial Activity of Novel Substituted Azetidinone Derivatives of Edaravone
International Journal of Drug Design and DiscoveryThis paper describes development of new chemical entities of Edaravone for their antibacterial activity. The chemical name of Edaravone is 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. Various N-(substituted benzylidenyl)-[2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)acetohydrazide] (4a-4e) and 2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)
R.V. Antre +3 more
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Effects of edaravone on human neutrophil function
Acta Anaesthesiologica Scandinavica, 2005Background: Neutrophils play a crucial role in the antibacterial host defence system. Edaravone is used in critically ill patients who are often immuno‐compromised secondary to concomitant disease or immunosuppressive therapy. The aim of the current study was to assess the effect of edaravone, a novel free‐radical scavenger, on several aspects of ...
K, Mikawa +4 more
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FDA approves edaravone for amyotrophic lateral sclerosis
American Journal of Health-System Pharmacy, 2017FDA on May 5 announced the approval of edaravone injection for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. ALS is a rapidly progressive, degenerative neurologic disorder that affects the control of motor neurons and results in the atrophy of muscles,
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Current opinion in investigational drugs (London, England : 2000), 2001
Mitsubishi-Tokyo (formerly Mitsubishi Chemical) is developing edaravone (norphenazone), a free radical scavenger, for the potential treatment of cardiovascular disease, cerebrovascular ischemia and cerebral edema. By February 2000, edaravone had been filed in Japan for the treatment of acute brain infarction, and was in phase III trials for ...
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Mitsubishi-Tokyo (formerly Mitsubishi Chemical) is developing edaravone (norphenazone), a free radical scavenger, for the potential treatment of cardiovascular disease, cerebrovascular ischemia and cerebral edema. By February 2000, edaravone had been filed in Japan for the treatment of acute brain infarction, and was in phase III trials for ...
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Edaravone Therapy: From Bench to Bedside
2014Stroke, the second leading cause of death throughout the world, typically results in a drastic reduction in the quality of life. The free radical scavenger edaravone was developed from translational research mainly using animal stroke models. It was approved in Japan in April, 2001 as a neuroprotective drug for the treatment of acute cerebral ...
Toru Yamashita, Koji Abe
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