Results 71 to 80 of about 14,917 (287)

Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model [PDF]

, 2015
published_or_final_versio
Chen, ZY, He, CY, Liu, YX, Tipoe, GL, Wang, XG, XIAO, J, Xing, FY, Zeng, W, Zheng, G   +8 more
core   +1 more source

Edaravone Dexborneol Downregulates Neutrophil Extracellular Trap Expression and Ameliorates Blood-Brain Barrier Permeability in Acute Ischemic Stroke

Mediators of Inflammation, 2022
Background Our previous work has shown that inflammatory processes play a detrimental role in the pathophysiology of acute ischemic stroke (AIS). Neutrophil extracellular traps (NETs) have been recognized as a key contributor to the proinflammatory ...
Yuanxiang Huang, Xiangjian Zhang, Cong Zhang, Wenting Xu, Wenshuo Li, Z. Feng, Xianglan Zhang, Keke Zhao   +7 more
semanticscholar   +1 more source

Solid Lipid Nanoparticles Loaded with Edaravone for Inner Ear Protection After Noise Exposure

Chinese Medical Journal, 2015
Background: Antioxidants and the duration of treatment after noise exposure on hearing recovery are important. We investigated the protective effects of an antioxidant substance, edaravone, and its slow-release dosage form, edaravone solid lipid ...
Gang Gao, Ya Liu, Chang-Hua Zhou, Ping Jiang, Jian-Jun Sun   +4 more
doaj   +1 more source

Edaravone: A Novel Possible Drug for Cancer Treatment?

International Journal of Molecular Sciences
Despite significant advancements in understanding the causes and progression of tumors, cancer remains one of the leading causes of death worldwide. In light of advances in cancer therapy, there has been a growing interest in drug repurposing, which ...
E. Duranti, N. Cordani, Chiara Villa
semanticscholar   +1 more source

Therapeutic Approaches to Vascular Protection in Ischemic Stroke [PDF]

, 2011
Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix
Abe, Koji, Yamashita, Toru
core   +1 more source

Safety of edaravone in acute ischemic stroke: A systematic review and meta-analysis

Neurology Asia, 2023
Background & Objective: Stroke is a major cause of death and disability, however many patients do not benefit from time-limited reperfusion therapies.
S. P. Badillo, J. Navarro
semanticscholar   +1 more source

A Statistical Model for Stroke Outcome Prediction and Treatment Planning

, 2016
Stroke is a major cause of mortality and long--term disability in the world. Predictive outcome models in stroke are valuable for personalized treatment, rehabilitation planning and in controlled clinical trials.
Bhattacharya, Sakyajit, Rajan, Vaibhav, Sarma, G R K, Sengupta, Abhishek   +3 more
core   +1 more source

Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis

Systematic Reviews, 2023
Background Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in field of SCI.
Xiaobo Wang, Long-yun Zhou, Xu-Qing Chen, Ran Li, B. Yu, Meng Pan, Lu Fang, Jian Li, Xue-jun Cui, Min Yao, Xiao Lu   +10 more
semanticscholar   +1 more source

Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Despite its clinical heterogeneity, amyotrophic lateral sclerosis is unified by early and prominent alterations in cortical excitability, increasingly recognized as contributors to disease progression. This study assessed whether the ratio between motor evoked potential (MEP) amplitude, reflecting upper motor neuron integrity, and compound ...
Federico Ranieri, Gianmaria Senerchia, Luigi Bonan, Stefania Casali, Corrado Cabona, Mariagiovanna Cantone, Fabiola De Marchi, Luca Diamanti, Alberto Doretti, Nicola Fini, Massimiliano Filosto, Andrea Fortuna, Aniello Iovino, Valentina Virginia Iuzzolino, Giuseppe Lanza, Christian Lunetta, Luca Maderna, Jessica Mandrioli, Letizia Mazzini, Gabriella Musumeci, Andi Nuredini, Gianni Sorarù, Antonella Toriello, Nicola Ticozzi, Massimiliano Todisco, Veria Vacchiano, Lucia Zinno, Vincenzo Silani, Simone Rossi, Vincenzo Di Lazzaro, Raffaele Dubbioso, on behalf of the MND Study Group of the Italian Neurological Society (SIN) and the Neurostimulation‐Neuromodulation Study Group of the Italian Society of Clinical Neurophysiology (SINC), Francesca Calvi, Maria Caputo, Stefano Gazzina, Laura Filippi, Rachele Piras, Marilisa Boscarino, Rita Bella, Manuela Pennisi, Fabio Pilato, Rosa Iodice   +41 more
wiley   +1 more source

Strong neuroprotection with a novel platinum nanoparticle against ischemic stroke- andtissue plasminogen activator-related brain damages in mice [PDF]

, 2012
Reactive oxygen species (ROS) are major exacerbation factor in acute ischemic stroke, and thrombolytic agent tissue plasminogen activator (tPA) may worsen motor function and cerebral infarcts. The platinum nanoparticle (nPt) is a novel ROS scavenger, and
Abe, Abe, Abe, Abu Fanne, Bederson, Bindokas, Chan, Chan, Cui, Deguchi, Demopoulos, Fanne, Gasche, Hamasaki, Hayashi, Hayashi, Hsiao, K. Abe, K. Deguchi, Kajita, Kamada, Kilic, Kilic, Kim, Kim, Kinouchi, Kitano, Klohs, Kontos, Kontos, Lansberg, Lukic-Panin, Lukic-Panin, M. Takamiya, Machado, Morimoto, Nagai, Nagotani, Ning, Onizawa, Perfeito, Peters, Roucoux, Saitoh, Sakaue, Sharma, Sugawara, T. Yamashita, Takamiya, The Edaravone Acute Brain Infarction Study Group, Tsirka, Tsuji, Wahlgren, Wang, Wang, Watanabe, Y. Miyamoto, Y. Ohta, Yagi, Yamashita, Yamashita, Yoneda, Yong, Zhang, Zhang   +64 more
core   +1 more source