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Advanced Science, Volume 12, Issue 45, December 4, 2025.Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang +10 more
wiley +1 more source
Edaravone exerts brain protective function by reducing the expression of AQP4, APP and Aβ proteins
Open Life Sciences, 2019 This study aims to investigate the changes of aquaporin-4 (AQP4), β-amyloid precursor proteins (APP) and β-amyloid (Aβ) in brain tissues after cerebral ischemiareperfusion injury (CIRI), and evaluate the effect of edaravone.
Ren Haiyan +7 more
doaj +1 more source
Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats
Neural Regeneration Research, 2015 Edaravone has been shown to delay neuronal apoptosis, thereby improving nerve function and the microenvironment after spinal cord injury. Edaravone can provide a favorable environment for the treatment of spinal cord injury using Schwann cell ...
Shu-quan Zhang +6 more
doaj +1 more source
The effect of edaravone on a rat fracture model complicated with ischemia
, 2021 Mehmet Burtaç Eren
openalex +2 more sources
The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson’s Disease [PDF]
, 2022 Isaac Bul Deng +3 more
openalex +1 more source
Journal of Pharmacological Sciences, 2013 Edaravone is clinically used in Japan for treatment of patients with acute cerebral infarction. To clarify the effect of edaravone on neurogenesis in the hippocampus following neuronal injury in the hippocampal dentate gyrus, we investigated the effect ...
Maho Kikuta +7 more
doaj +1 more source
Edaravone: A new drug approved for ALS
Cell, 2017 Amyotrophic lateral sclerosis (ALS) is a progressive, adult onset neurodegenerative disease that is always fatal. The history of ALS drug discovery is fraught with many stops and starts. It took 22 years after the FDA approval of the anti-excitotoxic drug Riluzole before another drug was found to be effective in altering ALS progression: the anti ...
openaire +2 more sources
Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats
Acta Neurologica TaiwanicaPurpose: This study aims to investigate the effect of edaravone in preventing cisplatin-induced brain damage. Methods: Forty female Wistar albino rats were included in the study. 4 groups were created. In group 1 (control group) (n=10), neither any drugs
Ozlem Kara, Asuman Kilitci
doaj +1 more source
BMC Neurology, 2011 Background Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate.
Suzuki Akifumi +2 more
doaj +1 more source