Results 51 to 60 of about 648,615 (347)

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

When the ignored gets bound: sequential effects in the flanker task [PDF]

, 2013
Recent research on attentional control processes in the Eriksen flanker task has focused on the so-called congruency sequence effect a.k.a. the Gratton effect, which is the observation of a smaller flanker interference effect after incongruent than after
Davelaar, Eddy J.
core   +2 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

The prospect of using LES and DES in engineering design, and the research required to get there [PDF]

, 2014
In this paper we try to look into the future to divine how large eddy and detached eddy simulations (LES and DES, respectively) will be used in the engineering design process about 20-30 years from now.
Larsson, Johan, Wang, Qiqi
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Energetics of the global ocean: The role of mesoscale eddies [PDF]

, 2016
This article reviews the energy cycle of the global ocean circulation, focusing on the role of baroclinic mesoscale eddies. Two of the important effects of mesoscale eddies are: (i) the flattening of the slope of large-scale isopycnal surfaces by the ...
Aiki, Hidenori, Greatbatch, Richard J., Zhai, Xiaoming   +2 more
core  

Eddy heat fluxes from direct current measurements of the Antarctic Polar Front in Shag Rocks Passage [PDF]

, 2008
Determining meridional heat flux in the Southern Ocean is critical to the accurate understanding and model simulation of the global ocean. Mesoscale eddies provide a significant but poorly-defined contribution to this transport.
Bryden, Bryden, Bryden, Charnock, David P. Stevens, de Szoeke, Gille, Gordon, Graham J. Walkden, Hall, Hall, Heywood, Jayne, Johnson, Karen J. Heywood, Keffer, Moore, Naveira Garabato, Newton, Nowlin, Nowlin, Orsi, Pawlowicz, Phillips, Sciremammano, Sciremammano, Sievers, Smith, Stammer, Trenberth   +29 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Financial Distress and Its Determinants in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective To quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent prolonged use of expensive disease‐modifying therapies. Methods We identified adults enrolled in the FORWARD databank with either RA or noninflammatory musculoskeletal disease (NIMSKD) completing the ...
Amber Brown Keebler, Yunju Im, Sofia Pedro, Ted R. Mikuls, Edward S. Peters, Kaleb Michaud   +5 more
wiley   +1 more source

Formation of record-breaking 2015/2016 winter marine heatwave in the northwest South China Sea

Frontiers in Marine Science
The South China Sea (SCS) has undergone multiple marine heatwaves (MHWs) over the past few decades. Daily reanalyzed sea surface temperature (SST) data are applied to identify major MHWs in the northwest SCS over 1982–2021.
Botao Xie, Hang Sun, Hang Sun, Tao Liu, Weifang Jin, Feilong Lin, Linxi Meng, Yuntao Wang   +7 more
doaj   +1 more source